Aspiration cytology of Hashimoto's thyroiditis in an endemic area

Kumar, Neeta; Ray, Chetan; Jain, Shyama

doi:10.1046/j.1365-2303.2002.00366.x

Cited by 59 publications

(81 citation statements)

References 6 publications

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“…A cytologic diagnosis of thyroiditis can be very puzzling at times, and the clinical and immunologic findings must be considered [36,37]. A clinical picture of a tender gland with small inconspicuous nodules whose cytology shows mature lymphocytes, plasma cells, and scattered giant cells is likely to be a granulomatous thyroiditis (De Quervain’s).…”

Section: Benign Diseases Of the Thyroidmentioning

confidence: 99%

Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid Gland

Fadda

Rossi²

2011

Acta Cytologica

123

148

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Objectives: Fine-needle aspiration biopsy is regarded as the most important diagnostic tool for thyroid lesions because of its simplicity, safety, and cost-effectiveness. However, its pivotal role in the correct characterization of the majority of nodules is impaired by the difficulties in discriminating benign from malignant follicular-patterned lesions. Study Design: Liquid-based cytology (LBC) is a semiautomated device that has recently become widely available and has gained popularity as a method of collecting and processing both gynecologic and nongynecologic cytologic specimens. It achieves a diagnostic sensitivity as accurate as conventional preparations, especially for its excellent cell preservation and lack of background which decrease the amount of inadequate diagnoses. Results: In many cases the cytologic features are similar in both methods, but the colloid film and the lymphocytic component are more easily evaluated on direct smears whereas nuclear details and colloid globules are better evaluated in LBC slides. The material stored in the preservative solution could be effectively used for the application of immunocytochemical and molecular techniques. Conclusions: LBC-processed biopsies represent a valid alternative to conventional cytology. The possibility of applying additional techniques enhances the efficacy of the cytologic diagnosis of thyroid lesions.

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Section: Benign Diseases Of the Thyroidmentioning

confidence: 99%

Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid Gland

Fadda

Rossi²

2011

Acta Cytologica

123

148

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“…Chronic lymphocytic thyroiditis (CLT) or Hashimoto's thyroiditis (HT) has a prevalence of 1-4% and incidence of 3-6/100 000 population per year (1), and is the result of a combination of genetic (endogenous) and nongenetic (exogenous) factors (2). Its incidence is rising, and pollution could be one reason for such increase (2,3,4,5,6).…”

Section: Introductionmentioning

confidence: 99%

Chronic lymphocytic thyroiditis: could it be influenced by a petrochemical complex? Data from a cytological study in South-Eastern Sicily

Arena

Latina

Baratta

et al. 2015

European Journal of Endocrinology

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Introduction: In genetically predisposed individuals, exogenous factors (including pollution) influence the development of Hashimoto's thyroiditis/chronic lymphocytic thyroiditis (CLT). CLT may also be a risk factor for associated thyroid cancer. Few data are available on the role of pollution from petrochemical complexes, one of which is located in the Siracusa province (South-Eastern Sicily), in the pathogenesis of CLT. Aims: i) To study the frequency of CLT in fine-needle aspiration cytology (FNAC)-interrogated thyroid nodules from patients who were stably resident in their zones, comparing it in patients living in the petrochemical complex area (zone A) with that of patients from a control area (zone B). ii) To study the frequency of CLT in the FNAC categories of malignancy risk, comparing the two zones. Patients and methods: We retrospectively evaluated cytologically adequate slides of 1323 nodules in 1013 outpatients who underwent ultrasound-guided FNAC from 2006 to 2012. We stratified by area of residence, gender, and FNAC categories of malignancy risk. Results: CLT was detected with significantly greater frequency in either patients or nodules from zone A compared with zone B (32.0% vs 23.1%, PZ0.002 or 28.2% vs 18.8%, PZ0.0001), with a female preponderance (FZ35.2% vs MZ21.1% or 30.4% vs 20.4%, zone A and FZ26.5% vs 12.3% or 21.6% vs 9.5%, zone B). Regardless of zone, CLT was approximately twofold more frequent in the suspiciously malignantCmalignant classes (TH4CTHY5Z47.6%, zone A and 32.4%, zone B) compared with the benignCintermediate classes (THY2CTHY3Z27.3%, zone A and 18.2%, zone B), but with a clear stepwise THY2 through THY5 increase only in zone A (THY2Z25.3%, THY5Z66.7%; THY2Z18.6%, THY5Z28.6% in zone B). Conclusions: The petrochemical complex-related pollution is an environmental factor involved in the development of CLT and, likely, in the CLT association with thyroid neoplasms.

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“…1 Hashimoto's thyroiditis also known as chronic lymphocytic thyroiditis has a prevalence rate of 1-4% and incidence of 3-6/10000 population per year. 2 It is the second most common thyroid lesion diagnosed by cytology, after endemic goiter. 3 This disorder is more common in women than in men.…”

Section: Introductionmentioning

confidence: 99%

“…3 In the usual clinical course, hypothyroidism develops gradually. 2 Incidence of Hashimoto's thyroiditis seems to be increasing in the recent times. 4,5 MATERIAL AND METHOD: The Study was conducted in the department of pathology at Dr Rajendra Prasad Government Medical College Kangra Himachal Pradesh.…”

Section: Introductionmentioning

confidence: 99%

“…(Table3)FNAC is considered superior as well as more cost-effective in diagnosing Hashimoto's thyroiditis than antibody screening. 8,10,11,12,13 Despite its superiority, FNAC has some pitfalls in diagnosing Hashimoto's thyroiditis. There is sometimes an overlap in the cytomorphological features of Hashimoto's thyroiditis and sub-acute lymphocytic thyroiditis Hurthle cell change was seen in 80%, which is higher than that seen in other studies.…”

Section: Introductionmentioning

confidence: 99%

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Cytomorphological and Biochemical Correlation in Thyroiditis

Krishna¹,

Manju²

2015

jemds

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Hashimoto's thyroiditis is an autoimmune chronic inflammatory disease of the thyroid gland. It is the second most common thyroid lesion diagnosed by cytology, after goiter. MATERIAL AND METHOD: The Study was conducted in the department of pathology. All aspiration were done by cytopathologists to ensure representative sampling.Using sterile precautions FNAC was performed using nonaspiration or aspiration techniques by 23 G needle with 10 ml syringe. The smears were either air dried or alcohol fixed (95%). Air dried smears were stained by the Gimsa stain and alcohol fixed by Hematoxiline and eosin. RESULT: We included 75 cases of thyroiditis. 4 cases were male and 71 were female with female to male ratio of 17.75:1. The age ranged from 8 to 65years with a median age of 36.5 years. 75 csaes of thyroiditis have been evaluated on the basis of cytomorphological criteria, Biochemical and clinical findings of patients. CONCLUSION: FNAC is a safe, reliable, cost effective and time saving method in the diagnosis of thyroiditis.

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Aspiration cytology of Hashimoto's thyroiditis in an endemic area

Cited by 59 publications

References 6 publications

Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid Gland

Liquid-Based Cytology in Fine-Needle Aspiration Biopsies of the Thyroid Gland

Chronic lymphocytic thyroiditis: could it be influenced by a petrochemical complex? Data from a cytological study in South-Eastern Sicily

Cytomorphological and Biochemical Correlation in Thyroiditis

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