Aspiration Following Elective Intubation

Bohman, J. Kyle

doi:10.1378/chest.14-1459

Cited by 1 publication

(2 citation statements)

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“…The primary outcome of interest was the effectiveness of cricoid pressure in reducing the frequency of microaspiration during intubation of surgical patients with risk factors for microaspiration. In our preliminary studies, we found an incidence of microaspiration of 4.5% and 12.5% for those undergoing elective intubation without risk factors for microaspiration and with risk factors for microaspiration, respectively . Based on the assumption that the “true” frequency of microaspiration is 12.5% in the control group and 4.5% (Relative Risk = 0.36) in the cricoid pressure group, a sample‐size of 400 (200 per group) would have been required to provide statistical power (two‐tailed, alpha = 0.05) of 80%.…”

Section: Methodsmentioning

confidence: 98%

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A pilot randomized clinical trial assessing the effect of cricoid pressure on risk of aspiration

Kashyap

Lee

et al. 2016

Clinical Respiratory J

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Introduction: Patients at risk for microaspiration during elective intubation often receive cricoid pressure in the hopes of mitigating such risk. However, there is scarce evidence to either support or reject this practice. The objective of this investigation was to assess the effect of cricoid pressure on microaspiration and to inform the potential feasibility of conducting a larger, more definitive clinical trial.

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Section: Methodsmentioning

confidence: 98%

“…Samples with a pepsin A concentration > 0.1 ng/mL were labeled as “pepsin A present” (microaspiration positive). The lower sensitivity threshold for the ELISA pepsin A assay was 0.1 ng/mL, therefore any values reported as 0.1 or less may have simply been “noise.”…”

Section: Methodsmentioning

confidence: 99%