Aspiration Pneumonitis Prophylaxis in Obstetric Anesthesia

Ormezzano, X.; Francois, T.; Viaud, Julien; Bukowski, J.G.; Bourgeoneau, M. C.; Cottron, D.; Ganansia, M. F.; Gregoire, F; Grinaud, M. R.; Wessel, P.

doi:10.1097/00132582-199101000-00032

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“…L sodium citrate raises the gastric pH to values of between 4.4 ± 1.5 and 5.3 ± 1.4 (Gibbs & Banner 1984;Ormezzano et al 1990), making the development of an aspiration pneumonitis unlikely (Lewis et al 1971;Morgan 1991). L sodium citrate raises the gastric pH to values of between 4.4 ± 1.5 and 5.3 ± 1.4 (Gibbs & Banner 1984;Ormezzano et al 1990), making the development of an aspiration pneumonitis unlikely (Lewis et al 1971;Morgan 1991).…”

Section: Discussionmentioning

confidence: 99%

An Oral Sodium Citrate-Citric Acid Nonparticulate Buffer

1993

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A new non particulate buffering solution of sodium citrate and citric acid was tested for its in vitro acid buffering abilities and its potential for producing a chemical pneumonitis when instilled down the endotracheal tube of anaesthetised beagle dogs. 25ml of the agent buffered l65ml of O.IN hydrochloric acid pH 1.4 to a pH of 3.05. Ten beagle dogs were anaesthetised and had 0.4 ml/kg of the buffering agent instilled down the endotracheal tubes. Thereafter the dogs recovered and two were sacrificed every 24 hours. Arterial blood samples were taken regularly for blood gas analysis. Moderate transient arterial blood gas changes were observed in the first 6 to 12 hours. Pulmonary macroscopic and microscopic examination demonstrated no signs of a chemical pneumonitis.We conclude that this agent is effective in raising the pH of hydrochloric acid and that it lacks the potential for canine pulmonary toxicity.

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