Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin

Walker, Jaqui; Hutchison, Pippa; Ge, Junbo; Zhao, Dong; Wang, Yongjun; Rothwell, Peter M.; Gaziano, J. Michael; Chan, Andrew T.; Burn, John; Chia, John Whay Kuang; Langley, Ruth E.; O'Donnell, Valerie Bridget; Rocca, Bianca; Hawkey, C. J.

doi:10.3332/ecancer.2018.813

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…Synthetic aspirin is derived from salicylic acid, a natural compound from myrtle, willow, and meadowsweet, which has been used in herbal medicine since ancient times for its anti-inflammatory effects. Clay tablets from the Assyrians (around 2000 BCE) showcase that willow leaves were advised for the treatment of rheumatic disease; moreover, Hippocrates (460-377 BCE) prescribed an extract of willow bark for labor and fever pain [3]. In 1876, Dr. T. MacLagan performed the first clinical study of salicylate by administering salicin to achieve the full remission of joint inflammation and fever in patients suffering from acute rheumatism.…”

Section: Antiplateletsmentioning

confidence: 99%

<p>Progress in Diagnosis and Treatment: The Last 50 Years of Stroke Prevention</p>

Antonenko,

Mosconi

2023

History of Stroke

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Stroke is a major global health issue. However, up to 85% of strokes may be preventable. Following an integrated conceptual timeline, we briefly report historical notes on the birth of and advancements in research on the pathophysiology and treatments of the major risk factors associated with ischemic stroke. We finally focused on the last 50 years, representing a landmark in the progress of stroke medicine. We reviewed and reported the results of the significant trials on the main stroke risk factors. The design and the results of large-scale epidemiological studies have clarified many of the underlying mechanisms of stroke pathophysiology, which has led to impressive developments in treating diseases that were considered untreatable for centuries. Although stroke is a largely preventable disease, there are still many issues faced when implementing strategies to reduce the global burden of the disease, both in terms of primary and secondary prevention.

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Section: Antiplateletsmentioning

confidence: 99%

<p>Progress in Diagnosis and Treatment: The Last 50 Years of Stroke Prevention</p>

Antonenko,

Mosconi

2023

History of Stroke

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“…Early detection and prevention are widely recognised to be key in combatting this disease. Aspirin and related non-steroidal anti-inflammatory drugs (NSAIDs) are one group of agents that have shown remarkable potential in the prevention of colorectal cancer [ 118 , 119 , 120 ]. Indeed, it has been suggested that long term aspirin use could lower colon and rectal cancer risk by up to 50%.…”

Section: Aspirin Acts Against Colon Cancer Cells By Targeting the Nf-κb Nucleolar Stress Response Pathwaymentioning

confidence: 99%

The NF-κB Nucleolar Stress Response Pathway

Thoms

Stark

2021

Biomedicines

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The nuclear organelle, the nucleolus, plays a critical role in stress response and the regulation of cellular homeostasis. P53 as a downstream effector of nucleolar stress is well defined. However, new data suggests that NF-κB also acts downstream of nucleolar stress to regulate cell growth and death. In this review, we will provide insight into the NF-κB nucleolar stress response pathway. We will discuss apoptosis mediated by nucleolar sequestration of RelA and new data demonstrating a role for p62 (sequestosome (SQSTM1)) in this process. We will also discuss activation of NF-κB signalling by degradation of the RNA polymerase I (PolI) complex component, transcription initiation factor-IA (TIF-IA (RRN3)), and contexts where TIF-IA-NF-κB signalling may be important. Finally, we will discuss how this pathway is targeted by aspirin to mediate apoptosis of colon cancer cells.

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“…However, interpatient variability to antiplatelet medications has the risk of undermining the revascularization benefit by raising the frequency of unfavorable events. Within 24 hours of surgery, aspirin is frequently advised, however this doesn't work to stop thrombosis in the critical early postoperative stage (Walker et al, 2018).When aspirin is taken up until surgery, some observational studies have showed improved outcomes, including decreased death (Rothwell et al, 2012). These trials revealed no indication that perioperative aspirin significantly increased the risk of bleeding or other related complications, despite the fact that it may have a preventive impact against a variety of thrombotic risks and reduced mortality (Columbo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Outcome With or Without Aspirin in Patients Undergoing Coronary Artery Bypass Surgery

IQBAL

KHALID

INAM

et al. 2022

Biol Clin Sci Res J

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Preoperative use of aspirin in coronary artery bypass graft surgery (CABG) might rely more on surgeon’s preference rather than on evidence-based approach. Conflicting guidelines and lack of reliable recommendations make ambiguous the preoperative aspirin administration before elective CABG. This study was conducted to compare the outcome with or without aspirin in patients undergoing coronary artery bypass surgery. The aim of the study was to compare the outcome with or without aspirin in patients undergoing coronary artery bypass surgery. This Randomized controlled trial was conducted at the Department of Cardiac Surgery, AFIC/ NIHD, Rawalpindi from 11th Dec 2018 to 10th June 2019. One hundred and fifty patients fulfilling inclusion criteria underwent through CABG were divided into two groups. In group A, 75 patients continued aspirin, while in group B, aspirin was stopped 5 days before surgery. Patient’s demographic features, comorbid conditions, Postoperative bleeding, perioperative MI and need for blood transfusion were noted. The mean age and BMI of patients were 61.41 ± 3.09 and 63.96 ± 7.64 years and 28.98 ± 2.46 and 32.61 ± 1.98 Kg/m2 in group A and B, respectively. Male to female ratios were 3.41:1 and 4.35:1 in group A and B, respectively. Diabetes and hypertension were seen in 67(89.34%) and 59(78.67%) patients and 69(90.67%) and 70(93.34%) patients in group A and B, respectively. Perioperative MI and blood transfusion were statistically significant among both groups (5.34% vs. 9.34% patients; p=0.0001 and 5.34% vs. 1.34%; p=0.0003). Mean postoperative bleeding was 401.39 ± 121.04 and 389.21 ± 101.13 ml/24 hr. in group A and B, respectively. The continuation of aspirin therapy in patients undergoing elective CABG reduces perioperative MI, increases quantity of postoperative bleeding and need for blood transfusion. There is a significant difference in outcome with or without aspirin in patients undergoing coronary artery bypass surgery.

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Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin

Cited by 7 publications

References 46 publications

<p>Progress in Diagnosis and Treatment: The Last 50 Years of Stroke Prevention</p>

<p>Progress in Diagnosis and Treatment: The Last 50 Years of Stroke Prevention</p>

The NF-κB Nucleolar Stress Response Pathway

Comparison of Outcome With or Without Aspirin in Patients Undergoing Coronary Artery Bypass Surgery

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