Aspirin and alcohol in gastrointestinal haemorrhage

Needham, C. D.; Kyle, J.; Jones, P. F.; Johnston, Stephen; Kerridge, D. F.

doi:10.1136/gut.12.10.819

Cited by 52 publications

(8 citation statements)

References 8 publications

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“…The definite effect of aspirin, the lack of effect of alcohol alone, and the remarkable synergistic effect of alcohol plus aspirin in promoting bleeding have already been reported (Needham et al, 1971). Most of the patients who bled while on anticoagulant therapy were somewhat out of control but constituted only a small proportion (1-4% a year) of all those on long-term therapy at that time.…”

Section: Discussionmentioning

confidence: 84%

“…Ingestion of aspirin and alcohol was studied in some detail and was the subject of a separate report (Needham et al, 1971). For this study the aspirin or alcohol ingestion within 72 hours of the onset of bleeding in each of the six diagnostic groups was compared with (a) aspirin ingestion in a control group of 300 patients and (b) alcohol ingestion in the 118 of that control group who were questioned on this point.…”

Section: >70mentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology and Course of Gastrointestinal Haemorrhage in North-east Scotland

Johnston¹,

Jones²,

Kyle³

et al. 1973

BMJ

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Section: Discussionmentioning

confidence: 84%

Section: >70mentioning

confidence: 99%

Epidemiology and Course of Gastrointestinal Haemorrhage in North-east Scotland

Johnston¹,

Jones²,

Kyle³

et al. 1973

BMJ

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“…Subsequently, aplastic anemia and agranulocytosis (particularly associated with indomethacin) were also mentioned. Mortality rate due to use of nonsteroid anti-inflammatory drugs that was cal-culated for 10 6 patients was estimated 0.2 for paracetamol and 0.25 for metamizole sodium (26)(27)(28)(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

“…Based on clinical and control studies performed in the years 1970-1995 Andrade et al calculated an excess mortality index for 5 most commonly occurring side effects associated with the use of non-narcotic analgesics (metamizole sodium, paracetamol, propyphenazone) and nonsteroidal anti-inflammatory drugs (ketoprophen, acetylsalicylic acid, diclofenac, naproxen, indomethacin) (23)(24)(25)(26)(27)(28)(29)(30)(31)(32). The authors analyzed median excess mortality due to agranulocytosis, anaphylaxis, aplastic anemia, gastrointestinal bleeding as well as Stevens-Johnson syndrome and toxic epidermal necrolysis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

Srebrzyński

Ziółkowski

Płużańska

et al. 2008

Polish Journal of Surgery

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The aim of the study was to evaluate the analgesic effect of metamizole sodium administered intravenously during the day after surgery in patients operated on for nodular goitre -using the 11-point NAS scale (Numeric Analog Scale). Material and methods. The study was comprised of 114 patients who had undergone surgery for nontoxic: 84 (73.7%) or toxic: 30 (26.3%) nodular goitre. The goitre size, according to the WHO classification ranged between III and I° (2). I° goitre was found in 31 (27%) patients, II° goitre -in 46 (40.4%) patients and III° goitre -in 37 (32.4%) patients. The age of patients ranged between 22 and 75 years (median 53, IQR 43-61). The goitre was localized in the neck in 103 (90.4%) patients and it partially reached the superior aperture of the thorax with its lower poles in 11 (9.6%) patients. Patients with coexisting diseases such as diabetes mellitus or peripheral neuropathy were excluded from the study. Patients were randomly assigned to 4 groups. Group I included 38 subjects in whom metamizole sodium was applied at a dose of 1 g intravenously every 6 hours for a day after surgery; the first dose was administered at the moment of surgical wound closure. Group II included 37 patients in whom metamizole sodium was applied according to the above-mentioned regimen and, additionally the surgical wound was injected with 10 ml of bupivacaine 0.25%. Group III consisted of 36 patients in whom 1 g of metamizole was first administered intravenously thirty minutes before surgery and the subsequent doses were systematically repeated at time intervals of 6 hours (preemptive analgesia), avoiding buvacaine wound infiltration. Group IV included 40 patients in whom ketoprophen was administered intravenously at a dose of 0.1 g every 6 hours for a day after the procedure. Surgical wounds were not injected with buvacaine in these patients, similarly as in groups III and I. In case of severe pain patients could additionally receive morphine 1 mg on-demand. Results. Pain intensity was analyzed every 6 hours on NAS scale and pain scores ranged from 1 to 5.5. At all time points, the highest pain intensity scores were found in patients who received metamizole as monotherapy (group I) or ketoprofen (group IV), while the lowest were found in the groups where surgical wound was additionally injected with bupivacaine solution (group II) or additional metamizole dose was used before the procedure (group III). Patients from group II rated their pain intensity as slightly higher or similar to that in group III (statistically insiginficant). Similarly patients from group I had pain scores slightly higher or similar to scores reported in group IV (statistically insiginficant). Conclusions. 1. The most intense pain was observed during the first 12 hours after thyroid surgery. 2. Administration of metamizole sodium according to the regimen that was applied in groups II and III provided sufficient analgesia. 3. Infiltration of the surgical wound with buvacaine or administration of an additional dose of metamizole sodium prior ...

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“…There is some evidence that chronic gastritis may predispose to upper gastrointestinal bleeding during heavy ethanol ingestion (Winawer, Bejar, McCray, and Zamcheck, 1971). However, in a recent survey no association between alcohol ingestion and upper gastrointestinal haemorrhage was observed (Needham, Kyle, Jones, Johnston, and Kerridge, 1971). Differences in the histological status of the gastric mucosa from one study population to another might have accounted, in part, for the divergent findings observed in previous investigations.…”

mentioning

confidence: 93%

Gastric mucosal morphology and faecal blood loss during ethanol ingestion

Dinoso¹,

Meshkinpour²,

Lorber³

1973

Gut

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SUMMARYThe faecal blood loss of six alcoholic subjects with normal gastric mucosa, six with superficial gastritis, and six with atrophic gastritis was studied before and during ingestion of 40 % v/v ethanol using 51Cr-tagged red blood cells. No significant change in faecal blood loss was observed in the normal mucosa and superficial gastritis groups but all subjects with atrophic gastritis bad significant increases of faecal blood loss during ethanol ingestion. These observations suggest that gastric mucosal morphology may be an important determinant of gastric mucosal bleeding during the ingestion of alcohol.

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Aspirin and alcohol in gastrointestinal haemorrhage

Cited by 52 publications

References 8 publications

Epidemiology and Course of Gastrointestinal Haemorrhage in North-east Scotland

Epidemiology and Course of Gastrointestinal Haemorrhage in North-east Scotland

Analysis of the Analgesic Effect of Metamizole Sodium in Patients Operated on for Goitre

Gastric mucosal morphology and faecal blood loss during ethanol ingestion

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