1989
DOI: 10.1378/chest.95.2_supplement.12s
|View full text |Cite
|
Sign up to set email alerts
|

Aspirin and Other Platelet Active Drugs

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

1995
1995
2017
2017

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 63 publications
0
3
0
Order By: Relevance
“…[15][16][17][18][19][20][21][22]26 Aspirin acetylation leads to irreversible inhibition of cyclooxygenase (PGH synthase)-which is the first enzyme of PG synthesis-converting arachidonic acid to PGH2. 27,28 This enzymatic step explains the ambivalent action of aspirin which inhibits the production of both prostacyclin (vasodilator and antithrombotic) and thromboxanes (prothrombotics, broncho-and vasoconstrictors. 29,30 In general, prostaglandins play an important endogenous vasodilatory role and counteract the enhanced peripheral vasoconstriction state in hypertension and congestive heart failure.…”
Section: Theoretical Basis For the Ace-i/aspirin Interactionmentioning
confidence: 99%
See 1 more Smart Citation
“…[15][16][17][18][19][20][21][22]26 Aspirin acetylation leads to irreversible inhibition of cyclooxygenase (PGH synthase)-which is the first enzyme of PG synthesis-converting arachidonic acid to PGH2. 27,28 This enzymatic step explains the ambivalent action of aspirin which inhibits the production of both prostacyclin (vasodilator and antithrombotic) and thromboxanes (prothrombotics, broncho-and vasoconstrictors. 29,30 In general, prostaglandins play an important endogenous vasodilatory role and counteract the enhanced peripheral vasoconstriction state in hypertension and congestive heart failure.…”
Section: Theoretical Basis For the Ace-i/aspirin Interactionmentioning
confidence: 99%
“…It is unclear if these observations reflect absorption problems or altered pharmacodynamics. 27,34 Aspirin in hypertensive patients: clinical implications and future research Coronary artery and cerebro-vascular diseases are the most common serious complications of long standing hypertension. The widespread use of aspirin probably contributes significantly to reduction of cardiovascular morbidity and mortality among high risk hypertensive patients with concomitant cardiovascular problems 35 and therefore there is a great potential for combined treatment with aspirin and ACE-I.…”
Section: Ace-i Induced Cough As a Clinical Marker Of Ace-i Activitymentioning
confidence: 99%
“…They did not specifically mention the INR, or fibrinogen, although omission of the INR may have been due to the mixed use of the term at that time because 'INR' was standardized after reassessment of the International Sensitivity Index (ISI) in 1983 (WHO, 1983), and for several years thereafter its standardization was discussed or reviewed by several authors (e.g. see Hirsh et al, 1989). Thus, the report by Smith and Ambikapathy (1992)…”
Section: Discussionmentioning
confidence: 99%