Aspirin and Preeclampsia Prevention in Patients With Abnormal Uterine Artery Blood Flow

Abstract

Background:Preeclampsia is one of the leading causes of maternal mortality and morbidity. Its prevalence varies between 10-25% among high-risk pregnant patients.Objectives:The aim of this study was to determine whether treatment with acetylsalicylic acid (ASA) reduces the incidence of preeclampsia among pregnant women with abnormal uterine artery flow.Patients and Methods:In this double-blind, placebo controlled trial, 80 high-risk pregnant women with preeclampsia, who had abnormal findings on Doppler ultrasonography at 12-16 weeks of pregnancy (unilateral notch with RI ≥ 0.65 or bilateral notch with RI ≥ 0.55), were randomly divided into two groups; the intervention group was treated with ASA tablet 80 mg, one tablet per day, and the control group was given placebo. Then patients were followed until the end of their pregnancy period, and pregnancy outcomes, including development of preeclampsia, the intrauterine growth retardation (IUGR), prematurity, type of delivery, birth weight, and Apgar score at one and five minutes were assessed. Data were analyzed using the student's t-test, chi-square or Fisher's exact test, and multivariate logistic regression. P values less than 0.05 were considered statistically significant.Results:There were no significant differences between the two groups in terms of baseline characteristics. There was a significant difference between the ASA and placebo groups in the incidence of preeclampsia (2.5% versus 22.5%), adjusting for the neonatal and maternal covariates.Conclusions:ASA prophylaxis can be used for prevention of preeclampsia in high-risk patients with abnormal uterine artery.

Impact of low‐dose aspirin on adverse perinatal outcome: meta‐analysis and meta‐regression

“…Following review of the abstracts, 119 potentially suitable trials were selected for full review. Of these, 40 studies involving 34 807 participants, met the inclusion criteria and were included in the final analysis (Figure ).…”

“…Assessment of bias revealed that 21 (52.5%) studies were at low risk of bias (Figure S1). Nine (22.5%) studies had a high risk in one or more domains, predominantly due to lack of blinding (no placebo treatment in the control arm) or due to an inadequate method of treatment allocation/concealment. These studies were still included in the final analysis and sensitivity assessment was performed to assess the impact of bias on the outcomes.…”

The effectiveness when use of dipyridamole (curantil) in idiopathic forms of violation of utero-placental perfusion

“…беременности: ряд исследований подтверждает высокую прогностическую значимость нарушения гемодинамики в бассейне маточных артерий, при которых возрастает частота разития преэклампсии и развития синдрома внутри утробной задержки роста плода [4,[12][13][14]. В ряде исследований также показана высокая эффективность применения низких доз аспирина для предотвращения развития преэклампсии [15,16], данные последнего метаанализа нарушений допплерометрических показателей в первом триместре в маточных артериях включали 55 974 пациентки [17].…”

Clinical Procedures for the Prevention of Preeclampsia in Pregnant Women: A Systematic Review

“…Thus, the prediction of preeclampsia is paramount in performing appropriate procedures to reduce the prevalence of the disease by modifying antenatal care and pharmacological interventions in a timely manner. 9,10 Several clinical, biochemical and biophysical tests have been proposed to predict PE; however, none of them have proved to be useful in isolation to classify the preexisting maternal risk for PE with sufficient specificity and sensitivity for clinical use. Ideally, the predictive model should be simple, inexpensive, and easy to apply, so that it can be widely used in the clinical practice.…”