Aspirin and Senile Cataracts in Rheumatoid Arthritis

Cotlier, Edward

doi:10.1016/s0140-6736(81)91965-6

Cited by 75 publications

(25 citation statements)

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“…Orally administrated nonsteroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) have been proposed to protect against, as well as represent a risk factor for, cataract [1][2][3][4] . NSAIDs are used for their ability to reduce inflammation, pain and fever by inhibition of the enzyme cyclooxygenase (COX).…”

Section: Introductionmentioning

confidence: 99%

Intracellular Effects of NSAIDs/ASA in Oxidatively Stressed Human Lens Epithelial Cells in Culture

et al. 2008

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The aim of the study was to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)/acetylsalicylic acid (ASA) on human lens epithelial cells (HLECs) during oxidative stress. HLECs were exposed to H₂O₂ in the absence or presence of indomethacin, diclofenac, celecoxib (NSAIDs) or ASA for 24 h. HLECs were assayed for changes in superoxide and peroxide production and for variations in glutathione. Mitochondrial depolarization was measured using the membrane potential-sensitive dye JC-1. The results of the study include reduction in superoxide and peroxide production as well as reduction in glutathione depletion in oxidatively stressed HLECs incubated with low concentrations of NSAIDs/ASA. However, no protection against H₂O₂-induced mitochondrial depolarization by NSAIDs/ASA could be seen. In conclusion, NSAIDs/ASA display reactive oxygen species-scavenging properties in H₂O₂-exposed HLECs in culture.

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Section: Introductionmentioning

confidence: 99%

Intracellular Effects of NSAIDs/ASA in Oxidatively Stressed Human Lens Epithelial Cells in Culture

et al. 2008

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“…This 4 study found that aspirin is associated with significantly lower odds of cataract development. The proposed mechanism of aspirin mediated protection against cataract formation is not known, however studies have shown that lowering plasma tryptophan levels and reduced aldose reductase activity may be involved [39]. Further, the use of allopurinol suggested that it may be a risk factor for cataract formation [40].…”

Section: Discussionmentioning

confidence: 99%

Investigating Risk Factors for Cataract Using the Cerner Health Facts® Database

Raju¹,

Chisholm²,

Mosa³

et al. 2017

J Eye Cataract Surg

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“…Aspirin is unique among conventional nonsteroid anti-inflammatory drugs [16] . It has been reported earlier that aspirin may limit steroid-induced lens opacity in humans [17] . Numerous epidemiological and laboratory studies have demonstrated that aspirin can protect against the development of cataract, ischemic heart disease, stroke, Alzheimer's disease, colorectal cancer, and prostate cancer [18,19] .…”

mentioning

confidence: 81%

Protective Effect of Aspirin against Dexamethasone-Induced Cataract in Cultured Rat Lens

Zhang

Wang²,

Liu³

et al. 2006

Ophthalmic Res

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Purpose: To investigate the effect of aspirin on dexamethasone-induced cataract formation in cultured rat lenses. Methods: One hundred and forty-eight lenses were divided into 3 groups and cultured in vitro: control (DMEM), cataract (DMEM + 10 µM dexamethasone), aspirin (DMEM + 10 µM dexamethasone + 2 mM aspirin). Following incubation, the transparency of the lenses was evaluated daily using a dissecting microscope. Twelve lenses from each group were homogenized and the activities of enzymes (catalase, superoxide dismutase and lactate dehydrogenase) from supernatants were measured after 1, 3, 5 and 7 days of incubation, respectively. The ultrastructure of lenses from the control and cataract groups was observed on the completion of 7-day incubation. Results: Opacity was induced by dexamethasone in the nuclear region of the rat lenses. Lenses in the control group exhibited mist-like opacity and lenses in the cataract group showed dense nuclear opacity, whereas lenses in the aspirin-treated group only had a visible demarcation between nuclear and cortical regions at day 7. The activities of catalase, superoxide dismutase and lactate dehydrogenase in the cataract group decreased in a time-dependent manner. There was no significant loss of enzyme activities in either the control or the aspirin group throughout the incubation period. An orderly arrangement of fiber cells was noted, and the cell membrane, cell junction and organelles were normal in the control group. However, in the cataract group the arrangement of fiber cells was untidy and the lenses contained abnormal-appearing cells. The group exhibited swollen mitochondria, a large number of vacuoles and expanded extracellular lacunae. Conclusions:Dexamethasone induces nuclear cataract in the organ-cultured rat lens by chemically modifying proteins, including enzymes. The enzymes, including those that normally eliminate radial oxygen species, could be especially vulnerable. Aspirin significantly inhibits dexamethasone-induced cataract formation by inhibiting inactivation of those enzymes.

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Aspirin and Senile Cataracts in Rheumatoid Arthritis

Cited by 75 publications

References 0 publications

Intracellular Effects of NSAIDs/ASA in Oxidatively Stressed Human Lens Epithelial Cells in Culture

Intracellular Effects of NSAIDs/ASA in Oxidatively Stressed Human Lens Epithelial Cells in Culture

Investigating Risk Factors for Cataract Using the Cerner Health Facts® Database

Protective Effect of Aspirin against Dexamethasone-Induced Cataract in Cultured Rat Lens

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