Aspirin dose and six-month outcome after an acute coronary syndrome

Abstract

Although these data are non-randomized, they suggest that the aspirin dose upon discharge may influence the clinical course after unstable angina or acute MI.

Variable Platelet Response to Aspirin and Clopidogrel in Atherothrombotic Disease

“…Indeed, there is evidence to suggest that response to low-dose aspirin varies with anatomic distribution of atherothrombosis. 48 Secondary prevention studies in large populations, however, fail to show additional clinical benefit of higher aspirin doses. 23 Indeed, evidence that gastrointestinal injury increases as aspirin dose exceeds the dosage required for an antiplatelet effect, as well as the increasing prescription of combined antiplatelet therapy, may underlie the recent downward revision of recommended aspirin maintenance doses in patients with CAD.…”

Emergent Aspirin Use in Cardiovascular Disease in the Emergency Department: Oral Dosing versus Rectal Suppositories

“…11 Multiple other studies have shown that aspirin doses ranging from 30 to 325 mg show a differential increase in GI bleeding as aspirin dose is increased. [12][13][14] The differential GI bleeding with dose is consistent with the differential suppression of COX-I with dose. This does not include the slight increased risk of hemorrhagic stroke of 0.2 events per 1,000 patient-years of aspirin therapy.…”

Early versus late intravenous insulin administration in critically ill patients

“…Propensity score analysis has been used successfully to compare different treatment options in a nonrandomized design [23]. The strength and direction of association favoring early IIT was consistent after propensity score modeling regardless of method used for analysis (OR 0.16-0.31).…”

“…This has been used successfully to compare different treatment options in observational studies to minimize the effects of confounding by indication [23][24][25]. Propensity score for early vs. late administration of insulin was calculated for all patients.…”