Aspirin-exacerbated respiratory disease: not always “adult-onset”

Tuttle, Katherine L.; Schneider, T.; Henrickson, Sarah E.; Morris, David W.; Abonia, J. Pablo; Spergel, Jonathan M.; Laidlaw, Tanya M.

doi:10.1016/j.jaip.2016.05.016

Cited by 33 publications

(18 citation statements)

References 10 publications

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“…27 In a case series involving three children and adolescents with NERD, 24-hours urinary levels of prostaglandin D2, histamine, and 11β prostaglandin F2α, as well as serum IL-5 and IL-13 levels, are increased. 28 Additionally, mild baseline eicosanoid imbalance is detected in three adolescents aged 17 (2 of them) and 13 years using in vitro functional eicosanoid test. 29 Similar to the patients with NERD, patients with NECD also exhibit increased levels of baseline urinary LTE 4 levels, which further significantly increase together with the expression of the activation marker of basophils (CD203c) upon challenge with a strong COX-I inhibitor.…”

Section: Mechanis Ms Of N Said Hyper S En S Itivit Ymentioning

confidence: 99%

“…Furthermore, lung tissue lysates from PGE synthase −/− NERD‐like mice showed that IL‐33 is responsible from mast cell activation after a challenge with lysine‐aspirin and LTE 4 is responsible for IL‐33–dependent mast cell activation and airflow obstruction . In a case series involving three children and adolescents with NERD, 24‐hours urinary levels of prostaglandin D2, histamine, and 11β prostaglandin F2α, as well as serum IL‐5 and IL‐13 levels, are increased . Additionally, mild baseline eicosanoid imbalance is detected in three adolescents aged 17 (2 of them) and 13 years using in vitro functional eicosanoid test .…”

Section: Mechanisms Of Nsaid Hypersensitivitymentioning

confidence: 99%

“…Estrada‐Rodriguez et al compared 16 aspirin‐intolerant asthmatics aged between 2 and 14 years with aspirin‐tolerant asthmatic children and reported that, contrary to the results published on adults, females are not predisposed to aspirin hypersensitivity in childhood, and, interestingly, they even diagnosed an ASA‐H in a 1‐year‐old patient . More recent publications on childhood NERD include single case reports or case series . In a series of 10 CI NSAID‐induced hypersensitive patients with a mean age of 14.9 ± 1.5 years, the clinical features of this phenotype are thoroughly described .…”

Section: Epidemiology and Clinical Manifestations In Different Phenotmentioning

confidence: 99%

“…70 More recent publications on childhood NERD include single case reports or case series. 28,29,73,74 In a series of 10 CI NSAID-induced hypersensitive patients with a mean age of 14.9 ± 1.5 years, the clinical features of this phenotype are thoroughly described. 73 In this study, NERD was confirmed with at least two chemically unrelated positive NSAID provocation tests and patients were followed up for at least Also, these patients presented cutaneous manifestations associated with respiratory symptoms, during provocation tests, diverging from the clinical features of NERD in adults.…”

Section: Years) Was Firstly Confirmed With Placebo-controlled Opts Bymentioning

confidence: 99%

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Characteristics of NSAID‐induced hypersensitivity reactions in childhood

Cavkaytar

Toit

Caimmi

2018

Pediatric Allergy Immunology

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Non-steroidal anti-inflammatory drugs (NSAIDs) are available as over-the-counter drugs, and they are commonly used in children for their antipyretic, analgesic, and anti-inflammatory effects. NSAIDs are among the most frequently reported drugs associated with hypersensitivity reactions and even with anaphylaxis. A complete evaluation of the patients based on reported clinical manifestations, timing of the reaction, the presence of underlying disease, and reactions to other NSAIDs allows clinicians to stratify children with a history of reaction to NSAIDs. Although NSAID-induced hypersensitivity reactions have mainly been investigated in adults, recent studies have aimed to explore their epidemiology in the pediatric population. This review will cover the current understanding of clinical manifestations, the risk factors, and the different phenotypes of NSAID-induced hypersensitivity reactions with a comprehensive overview of the epidemiologic data from past to present and the practical approach to the management of NSAID hypersensitivity in children and adolescents.

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Section: Mechanis Ms Of N Said Hyper S En S Itivit Ymentioning

confidence: 99%

Section: Mechanisms Of Nsaid Hypersensitivitymentioning

confidence: 99%

Section: Epidemiology and Clinical Manifestations In Different Phenotmentioning

confidence: 99%

Section: Years) Was Firstly Confirmed With Placebo-controlled Opts Bymentioning

confidence: 99%

See 2 more Smart Citations

Characteristics of NSAID‐induced hypersensitivity reactions in childhood

Cavkaytar

Toit

Caimmi

2018

Pediatric Allergy Immunology

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“…Several other publications with limited pediatric AERD inclusion were referenced in this report [21].…”

Section: B Aspirin or Nonsteroidal Drug-exacerbated Pediatric Crs (Amentioning

confidence: 99%

Do Adult Forms of Chronic Rhinosinusitis Exist in Children and Adolescents?

Hopp

2017

Sinusitis

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Pediatric chronic sinusitis is currently designated as pediatric chronic rhinosinusitis. In most pediatric cases, sinusitis is considered as infectious. In the adult literature, a wider repertoire of chronic rhinosinusitis conditions is recognized. In this review, the adult forms of chronic rhinosinusitis are used as a framework for identifying and defining the potential spectrum of pediatric chronic rhinosinusitis that exists beyond the most recognized condition, pediatric infectious chronic rhinosinusitis.

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Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management

Heath

Hartzell

Putt

et al. 2018

Curr Allergy Asthma Rep

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Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex. New survey studies provide some consensus on prevalence and management of this disease in children. In this review, we highlight the differential diagnosis of pediatric CRS, including non-eosinophilic/infectious variants, eosinophilic variants with and without nasal polyps, allergic fungal sinusitis, aspirin-exacerbated respiratory disease, primary immunodeficiency, and disorders of mucociliary clearance. Further, we detail treatment options that should be considered. Finally, we feature emerging potential treatment options of CRS, including anti-immunoglobulin E, interleukin-5, and interleukin-4 receptor alpha subunit.

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Aspirin-exacerbated respiratory disease: not always “adult-onset”

Cited by 33 publications

References 10 publications

Characteristics of NSAID‐induced hypersensitivity reactions in childhood

Characteristics of NSAID‐induced hypersensitivity reactions in childhood

Do Adult Forms of Chronic Rhinosinusitis Exist in Children and Adolescents?

Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management

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