Aspirin-hydrogel ocular film for topical delivery and ophthalmic anti-inflammation

Abstract

Ocular drug delivery in hydrogel forming film form has several benefits over conventional dosage forms. Ophthalmic anti-inflammation study have been undertaken using topically applied aspirin in hydrogel film formulation. Hydroxypropyl methylcellulose (HPMC) matrix film formulation was prepared by solvent casting and evaporation technique by taking triethanolamine (TEA) as a plasticizer. Ex vivo corneal permeation as well as anti-inflammatory potential of aspirin was studied on carrageenan induced rabbit eye model. Moisture uptake was found to be in the range of 17.097 and 19.139 % for all the film formulations. Higher HPMC content in the film exhibited increased both the moisture uptake and content of swelling. Among the formulations the swelling order was found to be increasing according to the increasing amount of HPMC in the film. Presence of hydrogel matrix forming polymer sustained the drug release and corneal permeation for more than 6 h and controlled the process by diffusion mechanism. The signs of carrageenan induced acute inflammation have been inhibited completely just within 2 h of placing the film in the rabbit eye whilst the positive control continued showing redness and increased tear secretion. Aspirin ocular film formulation could be utilized for ocular anti-inflammation for an extended period of time with better patient compliance.