Aspirin Hypersensitivity in Patients with Chronic Rhinosinusitis and Nasal Polyposis: Frequency and Contributing Factors

Nabavi, Mohammad; Esmaeilzadeh, Hossein; Arshi, Saba; Bemanian, Mohammad Hassan; Fallahpour, Morteza; Bahrami, Ahmad; Mortazavi, Negar; Kamrava, Seyed Kamran; Farhadi, Mohammad; Taghipour, R; Rezaei, Nima

doi:10.2500/ajra.2014.28.4034

Cited by 24 publications

(22 citation statements)

References 33 publications

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“…We further compared the prevalence of asthma, allergies, and ASA syndrome (aspirin sensitivity, asthma and CRSwNP), the more commonly coexisting comorbidities in CRSwNP, among TAS2R38 genotypes in 84 patients. Chi‐square analysis showed no statistically significant difference between PAV taster and AVI nontaster, suggesting no association between receptor functionality and CRS‐related comorbidities (χ 2 : 6.113; P = 0.295).…”

Section: Resultsmentioning

confidence: 99%

In Vivo Biofilm Formation, Gram‐Negative Infections and TAS2R38 Polymorphisms in CRSw NP Patients

Cantone¹,

Negri

Roscetto

et al. 2018

The Laryngoscope

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Section: Resultsmentioning

confidence: 99%

In Vivo Biofilm Formation, Gram‐Negative Infections and TAS2R38 Polymorphisms in CRSw NP Patients

Cantone¹,

Negri

Roscetto

et al. 2018

The Laryngoscope

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“…Aspirin‐exacerbated respiratory disease (AERD) represents a challenging syndrome of adult‐onset asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and non–immunoglobulin E (IgE)‐mediated hypersensitivity to cyclooxygenase‐1 (COX‐1) inhibitors, such as acetylsalicylic acid (ASA) and other nonsteroidal anti‐inflammatory drugs (NSAIDS) . First recognized by Widal et al .…”

Section: Review Characteristicsmentioning

confidence: 99%

“…Among patients with CRSwNP, prevalence of AERD has been reported at 8% to 26%, with up to 40% developing aspirin sensitivity during the course of their disease . Although aspirin challenge represents the gold standard for diagnosis of AERD, understanding of the pathophysiology contributing to AERD remains incomplete.…”

Section: Review Characteristicsmentioning

confidence: 99%

Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin‐exacerbated respiratory disease: an evidence‐based review with recommendations

Levy

Rudmik

Peters

et al. 2016

Int Forum Allergy Rhinol

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Background Chronic rhinosinusitis (CRS) in aspirin exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the multidisciplinary management of CRS in AERD. Methods A systematic review of the literature was performed and the guidelines for development of an evidence-based review with recommendations were followed. Study inclusion criteria included: adult population>18 years old; CRS based on published diagnostic criteria and a presumptive diagnosis of AERD. We focused on reporting higher-quality studies (level 2 or higher) when available, but reported lower-quality studies if the topic contained insufficient evidence. Treatment recommendations were based on American Academy of Otolaryngology guidelines, with defined grades of evidence and evaluation of research quality and risk/benefits associated with each treatment. Results This review identified and evaluated the literature on 3 treatment strategies for CRS in AERD: dietary salicylate avoidance, leukotriene modification and desensitization with daily aspirin therapy. Conclusion Based on the available evidence, dietary salicylate avoidance and leukotriene modifying drugs are options following appropriate treatment with nasal corticosteroids and saline irrigation. Desensitization with daily aspirin therapy is recommended following revision ESS.

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“…Patients with NERD present as moderate‐to‐severe asthma, in which eosinophils are activated in the upper and lower airway mucosa . Compared to aspirin‐tolerant asthma (ATA), NERD is less associated with atopy; however, atopy is often present in patients with NERD .…”

mentioning

confidence: 99%

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

Lee

Kim

et al. 2016

Allergy

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Aspirin Hypersensitivity in Patients with Chronic Rhinosinusitis and Nasal Polyposis: Frequency and Contributing Factors

Abstract: ASA hypersensitivity is common in patients with CRSwNP in Tehran, Iran. Patients at risk for AERD should be evaluated for the presence of ASA hypersensitivity with ASA provocation challenge test to confirm the diagnosis.

Cited by 24 publications

References 33 publications

In Vivo Biofilm Formation, Gram‐Negative Infections and TAS2R38 Polymorphisms in CRSw NP Patients

In Vivo Biofilm Formation, Gram‐Negative Infections and TAS2R38 Polymorphisms in CRSw NP Patients

Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin‐exacerbated respiratory disease: an evidence‐based review with recommendations

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

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