Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B<sub>2,</sub> during infarct-prone early-morning hours

Racca, Cati; Diemen, Jeske Joanna Katarina van; Fuijkschot, Wessel W.; Spit, Karlinde A.; Bonten, Tobias N; Numans, Mattijs E.; Bom, Johanna G. van der; Smulders, Yvo M.; Thijs, Abel

doi:10.1080/09537104.2018.1528347

Cited by 14 publications

(23 citation statements)

References 30 publications

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“…The first finding, of a superior level of inhibition after ODevening intake of aspirin in comparison with OD-morning intake, is consistent with the results of several other studies, both in healthy subjects and patients with stable cardiovascular disease [11][12][13][14]25]. As most CVE's occur during -early morning hours [26,27], optimal platelet inhibition during these hours seems prudent.…”

Section: Discussionsupporting

confidence: 88%

“…As most CVE's occur during -early morning hours [26,27], optimal platelet inhibition during these hours seems prudent. In line with studies in healthy volunteers and patients with essential thrombocytosis, a BID-regimen resulted in a higher level of platelet inhibition than a OD-morning regimen [11,28] Interestingly, both the COX-1 dependent and independent platelet function test (i.e. sTxB 2 levels and the PFA-CT, respectively) demonstrated a higher level of platelet inhibition by the OD-evening, in comparison with the OD-morning regimen.…”

Section: Discussionsupporting

confidence: 76%

“…We therefore decided to perform our power analyzis solely based on the PFA-CT. The data were derived from a previously published trial with healthy volunteers [11]. Due to the skewed distribution of PFA-CT, the sample size calculation was based on the Wilcoxon signed-rank test.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“…In previous research by our group in healthy volunteers evening intake of a 12-hour dosing interval showed better platelet inhibition in critical early morning hours [11]. In view of these considerations, the objective of this trial was two-fold: 1.)…”

Section: Introductionmentioning

confidence: 98%

“…As mentioned above, the incidence of cardiovascular events adheres to such circadian rhythm, with a peak prevalence during the night and early morning. Previous research has suggested that changing the time of intake to evening or switching to a 12-hour dosing interval might result in higher levels of platelet inhibition [11][12][13][14]. Furthermore, even though megakaryocytes are able to produce new cyclooxygenase (COX), they can be inhibited by aspirin for a maximum of 12 hours [15].…”

Section: Introductionmentioning

confidence: 99%

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Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

et al. 2020

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 76%

Section: Sample Size Calculationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

et al. 2020

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Circadian Variation in Efficacy of Medications

Walton

Walker

Bumgarner

et al. 2020

Clin Pharma and Therapeutics

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Although much has been learned about circadian clocks and rhythms over the past few decades, translation of this foundational science underlying the temporal regulation of physiology and behavior to clinical applications has been slow. Indeed, acceptance of the modern study of circadian rhythms has been blunted because the phenomenology of cyclic changes had to counteract the 20th century dogma of homeostasis in the biological sciences and medicine. We are providing this review of clinical data to highlight the emerging awareness of circadian variation in efficacy of medications for physicians, clinicians, and pharmacists. We are suggesting that gold‐standard double‐blind clinical studies should be conducted to determine the best time of day for optimal effectiveness of medications; also, we suggest that time of day should be tracked and reported as an important biological variable in ongoing clinical studies hereafter. Furthermore, we emphasize that time of day is, and should be considered, a key biological variable in research design similar to sex. In common with biomedical research data that have been historically strongly skewed toward the male sex, most pharmaceutical data have been skewed toward morning dosing without strong evidence that this is the optimal time of efficacy.

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Not all (N)SAID and done: Effects of nonsteroidal anti‐inflammatory drugs and paracetamol intake on platelets

Driver

Marks

Wal

2020

Research and Practice in Thrombosis and Haemostasis

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractPlatelets are key mediators of hemostasis and thrombosis and can be inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs). As a result, platelet donors are temporarily deferred from donating if they have recently taken NSAIDs such as aspirin or ibuprofen. Despite these measures, a proportion of platelet donations show exposure to these drugs; however, little is known about the effect of NSAIDs and their metabolites on platelet quality in vivo and during storage. In this review, the effect of NSAIDs on platelet function is summarized, with a focus on the widely consumed over-the-counter (OTC) medications aspirin, ibuprofen, and the non-NSAID paracetamol. Aspirin and ibuprofen have well-defined antiplatelet effects. In comparison, studies regarding the effect of paracetamol on platelets report variable findings. The timing and order of NSAID intake is important, as concurrent NSAID use can inhibit or potentiate platelet activation depending on the drug taken. NSAID deferral periods and maximum platelet shelf-life is set by each country and are revised regularly. Reduced donor deferral periods and longer platelet storage times may affect the quality of platelet products, and it is therefore important to identify the possible impact of NSAID intake on platelet quality before and after storage. K E Y W O R D Sacetaminophen, anti-inflammatory agents, aspirin, blood platelets, ibuprofen, nonsteroidal Essentials• Nonsteroidal anti-inflammatory drugs (NSAIDs) can inhibit platelet aggregation and secretion by inhibiting cyclo-oxygenase 1.• The effect of paracetamol (acetaminophen) on platelets is poorly studied.• Little is known about the effect of NSAIDs and their metabolites on stored platelets.• Postponing platelet donation after NSAID intake may affect platelet quality following storage.

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Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B_2, during infarct-prone early-morning hours

Abstract: Thijs (2019) Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B 2, during infarct-prone earlymorning hours,

Cited by 14 publications

References 30 publications

Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

Circadian Variation in Efficacy of Medications

Not all (N)SAID and done: Effects of nonsteroidal anti‐inflammatory drugs and paracetamol intake on platelets

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Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B2, during infarct-prone early-morning hours

Abstract: Thijs (2019) Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B 2, during infarct-prone earlymorning hours,

Cited by 14 publications

References 30 publications

Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

Evening aspirin intake results in higher levels of platelet inhibition and a reduction in reticulated platelets - a window of opportunity for patients with cardiovascular disease?

Circadian Variation in Efficacy of Medications

Not all (N)SAID and done: Effects of nonsteroidal anti‐inflammatory drugs and paracetamol intake on platelets

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Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B_2, during infarct-prone early-morning hours