Aspirin intolerance and allergy to house dust mites: important factors associated with development of severe asthma

Kupczyk, Maciej; Kupryś, Izabela; Górski, Paweł; Kuna, Piotr

doi:10.1016/s1081-1206(10)61782-6

Cited by 35 publications

(19 citation statements)

References 17 publications

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“…The correlation found was low, and it was highly dependent on the four subjects in the severe persistent category. In other regions of the world, such a correlation has been recognized by several investigators [20,33,34]. The strength of the IgE antibody response to HDMs in humid climates could contribute to the increased prevalence and severity of asthma [30,34].…”

Section: Discussionmentioning

confidence: 93%

Skin Test Reactivity to Indoor Allergens Correlates with Asthma Severity in Jeddah, Saudi Arabia

Koshak

2006

All Asth Clin Immun

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BackgroundThere is increased emphasis on the role of indoor allergens in asthma.ObjectiveTo examine the spectrum of skin test reactivity (sensitization) to indoor allergens and its correlation with asthma severity in Jeddah, Saudi Arabia.MethodsAsthmatic patients referred to the allergy clinic at King Abdulaziz University Hospital (KAUH) in Jeddah were studied. Measures of clinical severity were adopted from national and international asthma guidelines. The degree of sensitization was assessed by the wheal size (positive ≥ 3 mm) from standard skin-prick tests for the following common indoor inhalant allergens: house dust mites (Dermatophagoides pteronyssinus [Dp] and Dermatophagoides farinae [Df]), cat, and cockroach.ResultsSkin test results from 113 of 151 (74.8%) asthmatic patients were positive for one or more allergens. The patients' ages ranged between 9 and 63 years (mean, 30 ± 13 years), and females constituted 65.5%. The predominant asthma severity level was moderate persistent (55.8%), followed by mild persistent (33.6%). The prevalences of sensitization to indoor allergens were as follows: Dp, 87% (3-25 mm [mean, 7 mm]); Df, 84% (3-20 mm [mean, 7 mm]); cat, 44% (3-15 mm [mean, 6 mm]); and cockroach, 33% (3-12 mm [mean, 4 mm]). Higher asthma severity levels were significantly correlated with the number of allergens with positive sensitization (R = 0.3, p < .001) and with the degree of sensitization to house dust mites (Dp [degrees of freedom {df} = 16, p < .001] and Df [df = 17, p < .01]) but not to cat (df = 10, p < .24) or cockroach (df = 8, p < .36).ConclusionsImmunoglobulin E-mediated skin test reactivity to indoor allergens, particularly to house dust mites, was common in asthmatic patients from Jeddah at KAUH. Increased sensitization was associated with higher levels of asthma severity, which is compatible with the literature. This emphasizes the importance of identifying sensitization to relevant indoor allergens in the clinical evaluation of asthmatic persons.

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Section: Discussionmentioning

confidence: 93%

Skin Test Reactivity to Indoor Allergens Correlates with Asthma Severity in Jeddah, Saudi Arabia

Koshak

2006

All Asth Clin Immun

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“…36 Although NERD patients were thought to be nonatopic, increasing evidence indicates that up to two thirds have a history of atopy. [37][38][39] Development of respiratory symptoms following NSAIDs intake has been reported by 1.8% of the general population, 40,41 7.1% of asthmatics, 40,42 14.9% of severe asthmatics and 9% of patients with NPs, 43 reaching one third of patients with asthma and NPs. 40,43 NERD may be suspected based on clinical history; however, the gold standard is oral acetyl salicylic acid (ASA)-DPT.…”

Section: Nerdmentioning

confidence: 99%

Progress in understanding hypersensitivity reactions to nonsteroidal anti‐inflammatory drugs

Doña

Pérez‐Sánchez

Eguiluz‐Gracia

et al. 2019

Allergy

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Nonsteroidal anti‐inflammatory drugs (NSAIDs), the medications most commonly used for treating pain and inflammation, are the main triggers of drug hypersensitivity reactions. The latest classification of NSAIDs hypersensitivity by the European Academy of Allergy and Clinical Immunology (EAACI) differentiates between cross‐hypersensitivity reactions (CRs), associated with COX‐1 inhibition, and selective reactions, associated with immunological mechanisms. Three phenotypes fill into the first group: NSAIDs‐exacerbated respiratory disease, NSAIDs‐exacerbated cutaneous disease and NSAIDs‐induced urticaria/angioedema. Two phenotypes fill into the second one: single‐NSAID‐induced urticaria/angioedema/anaphylaxis and single‐NSAID‐induced delayed reactions. Diagnosis of NSAIDs hypersensitivity is hampered by different factors, including the lack of validated in vitro biomarkers and the uselessness of skin tests. The advances achieved over recent years recommend a re‐evaluation of the EAACI classification, as it does not consider other phenotypes such as blended reactions (coexistence of cutaneous and respiratory symptoms) or food‐dependent NSAID‐induced anaphylaxis. In addition, it does not regard the natural evolution of phenotypes and their potential interconversion, the development of tolerance over time or the role of atopy. Here, we address these topics. A state of the art on the underlying mechanisms and on the approaches for biomarkers discovery is also provided, including genetic studies and available information on transcriptomics and metabolomics.

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“…Significant deterioration of lung function in many of those patients was also detected (23). In adults, risk factors for poor disease control included long duration of symptoms, aspirin (ASA)-hypersensitivity and house dust mite sensitization in adults (24). In asthmatic children, cockroach was one of three most common allergens causing sensitization.…”

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confidence: 99%

Reduction of asthma burden is possible through National Asthma Plans

Kupczyk

Haahtela

Cruz

et al. 2010

Allergy

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To cite this article: Kupczyk M, Haahtela T, Cruz AA, Kuna P. Reduction of asthma burden is possible through National Asthma. Allergy 2010; 65: 415–419.AbstractDespite increase in understanding of asthma patomechanisms the practical actions to lessen asthma burden in the communities are far behind of scientific knowledge. There are still reports of uderdiagnosis and poor treatment leading to repeated severe exacerbations, often demanding emergency care and hospitalisation, which cause most of the economic burden both for families and society. From the public health perspective, the key issue is to implement the best standards of care in every‐day practice. The problems are different in high income compared to low‐ and middle‐income countries, and the solutions have to be tailored to each country needs and resources. We present here examples from Finland, Poland and Brazil, to show that asthma burden can be reduced using varied strategies in quite different societal, economical and health care environments. The experience from those interventions confirms that regardless of the health care system and its coverage, a major change for the better can be achieved by local efforts, systematic planning and networking to implement the best asthma practice.

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Aspirin intolerance and allergy to house dust mites: important factors associated with development of severe asthma

Cited by 35 publications

References 17 publications

Skin Test Reactivity to Indoor Allergens Correlates with Asthma Severity in Jeddah, Saudi Arabia

Skin Test Reactivity to Indoor Allergens Correlates with Asthma Severity in Jeddah, Saudi Arabia

Progress in understanding hypersensitivity reactions to nonsteroidal anti‐inflammatory drugs

Reduction of asthma burden is possible through National Asthma Plans

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