Aspirin metabolism and efficacy in postoperative dental pain.

Seymour, R. A.; Williams, FM; Ward, Alan C.; Rawlins,

doi:10.1111/j.1365-2125.1984.tb02406.x

Cited by 41 publications

(21 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in our study, other investigations (Windorfer et al, 1974;Gupta & Gupta, 1977) have noted higher aspirin plasma esterase activity in males than in females. A close correlation (r = 0.90) between aspirin plasma esterase activity and aspirin AUC has been reported (Seymour et al, 1984) in patients with post-operative dental pain but the possible sex-dependency of this association was not determined. Interestingly, these authors also demonstrated a close correlation (r = 0.96) between aspirin AUC and analgesic effect suggesting that pain relief in post-operative dental pain is determined by aspirin hydrolysis rate.…”

Section: Discussionmentioning

confidence: 87%

Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.

Miners¹,

Grgurinovich²,

Whitehead

et al. 1986

Brit J Clinical Pharma

View full text Add to dashboard Cite

Salicylic acid and acetylsalicylic acid (aspirin) disposition after an oral dose of aspirin, 900 mg (equivalent to 689.7 mg of salicylic acid) was studied in eight males, eight females and eight females receiving oral contraceptive steroids (OCS). Salicylic acid clearance was 61% higher in males compared to the control female group, an effect due largely to enhanced activity of the glycine conjugation pathway (salicyluric acid formation) in males. Salicylic acid clearance was 41% higher in OCS‐users compared to the control female group due to increases in both the glycine and glucuronic acid conjugation pathways in the pill users. There was no difference in any salicylic acid disposition parameter between males and OCS‐users. Area under the plasma concentration‐time curve (AUC) and elimination half‐life of aspirin was significantly greater and aspirin plasma hydrolysis rate was significantly lower in both female groups compared to males. There was no difference between OCS‐users and the control female group in any of these parameters. Aspirin AUC and elimination half‐life were significantly correlated with aspirin plasma hydrolysis rate. These data confirm the importance of hormonal factors in the regulation of drug conjugation reactions in humans and suggest that sex‐related differences in salicylic acid and aspirin disposition may be of clinical importance.

show abstract

Section: Discussionmentioning

confidence: 87%

Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.

Miners¹,

Grgurinovich²,

Whitehead

et al. 1986

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…It has been previously shown that plasma concentrations of acetylsalicylate are also important determinants of aspirin's efficacy in postoperative dental pain. 2 By contrast, the absorption of solid paracetamol tablets is slow with a Tmax of 60 minutes. 13 Thus differences in pharmacokinetics may account for the differences in onset of analgesia observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…These include formulation, dose and plasma concentration of acetylsalicylate. [2][3][4][5] The latter appears to be determined by plasma aspirin esterase activity. By contrast, there is limited information on the efficacy of paracetamol in postoperative dental pain.…”

Section: Introductionmentioning

confidence: 99%

An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery

et al. 2003

View full text Add to dashboard Cite

Objective To compare the efficacy of soluble aspirin 900 mg and paracetamol 1,000 mg in patients with postoperative pain after third molar surgery. Design A randomised, placebo controlled, double-blind study. Setting Day stay units of Oral and Maxillofacial Surgery at Cardiff Dental Hospital and Hexham General Hospital, Northumberland. Subjects and methods One hundred and sixty-seven (104 female) patients who required the removal of their impacted third molars under general anaesthesia. Intervention In the early postoperative period, patients were medicated with either a single dose of soluble aspirin 900 mg, solid paracetamol 1,000 mg or placebo. Main outcome measures Pain intensity was measured on 100 mm visual analogue scales at 0,5,10, 15, 20, 30, 45, 60, 90, 120 and 240 minutes after dosing. Other efficacy variables evaluated included time to rescue medication and an overall assessment of the study medication efficacy by the patient on completion of the study. Results One hundred and sixty-seven patients consented to take part in the study, but only 153 were medicated. Of the 14 patients not treated, 10 failed to develop sufficient pain to enter the study, two withdrew consent, one had an adverse reaction to the general anaesthetic and one was a protocol violator. Over the four hour investigation period, patients treated with soluble aspirin reported significantly less pain when compared with those treated with paracetamol (mean difference in AUC 0-240 = -2001, 95% CI -3893 to -109, p=0.038) and placebo (mean difference in AUC 0-240 = -3470, 95% CI -5719 to -1221, p=0.003).

show abstract

“…Ingested aspirin is hydrolyzed in the gut by first pass metabolism, with about 50 -70% reaching systemic circulation (7,8). The circulating pool of aspirin is hydrolyzed with a half-life of ϳ15 to 20 min (9, 10), but contributes to platelet responsiveness because inhibition is distinctly nonlinear where even small amounts of active cyclooxygenase promote platelet function (11).…”

mentioning

confidence: 99%

Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood

Zhou

Marathe

Willard

et al. 2011

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Aspirin circulates transiently in blood, but the identity of the enzyme(s) that hydrolyzes its acetyl residue remains unknown. Results: Purification, mass spectrometry, and overexpression identified erythrocyte type I PAF acetylhydrolase as aspirin hydrolase. Conclusion: Aspirin is primarily hydrolyzed within erythrocytes by PAF acetylhydrolase. Significance: PAF acetylhydrolase and aspirin hydrolysis varies among individuals to modulate the effectiveness of aspirin.

show abstract

Aspirin metabolism and efficacy in postoperative dental pain.

Cited by 41 publications

References 12 publications

Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.

Influence of gender and oral contraceptive steroids on the metabolism of salicylic acid and acetylsalicylic acid.

An investigation into the comparative efficacy of soluble aspirin and solid paracetamol in postoperative pain after third molar surgery

Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood

Contact Info

Product

Resources

About