Aspirin, prostacyclin and post-occlusive reactive hyperaemia in man

Tooke, John E.; Menys, V.C.; Tindall, H; Feely, M.; Davies, J. A.

doi:10.1016/0262-1746(82)90094-4

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…These findings are consistent with previous reports that have demonstrated no changes in basal forearm, or finger blood flow after prostacyclin inhibition [21,22]. On the other hand, it has been shown that vasodilator prostaglandins may be involved in the forearm muscle post-occlusive reactive hyperaemic blood flow [21], but not in the finger hyperaemic response [22]. In addition, prostaglandins apparently play a role in the autoregulation of splanchnic and renal blood flow [23,24], and possibly in the regulation of venous tone [25].…”

Section: Discussionsupporting

confidence: 93%

“…These data suggest that, in healthy subjects, prostaglandins are not involved in the local regulation of basal forearm (muscle), skin thermoregulation, and skin nutritive blood flow. These findings are consistent with previous reports that have demonstrated no changes in basal forearm, or finger blood flow after prostacyclin inhibition [21,22]. On the other hand, it has been shown that vasodilator prostaglandins may be involved in the forearm muscle post-occlusive reactive hyperaemic blood flow [21], but not in the finger hyperaemic response [22].…”

Section: Discussionsupporting

confidence: 92%

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Peripheral macro‐and microcirculation in short‐term insulin‐dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes

Houben

Kruseman

Bouhouch

et al. 1993

Eur J Clin Investigation

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To determine whether vasodilator prostaglandins are involved in the peripheral hyperperfusion observed in patients with short-term insulin-dependent diabetes mellitus (IDDM), forearm and skin blood flow were studied before and after cyclooxygenase inhibition. Skin nutritive (CBV: capillary blood-cell velocity) and thermoregulatory (LDF: laser-Doppler fluxmetry), and forearm (muscle) blood flow (FBF) were measured before and after 500 mg acetylsalicylic acid (ASA) infused intravenously in 14 short-term IDDM patients and 22 healthy control subjects. In the IDDM patients, baseline LDF (median: 27 (19-35); interquartile range) vs. 17 (15-23) pu) and FBF (3.4 (2.5-4.1) vs. 2.6 (2.2-2.9) ml 100 ml-1 min-1) were increased, while CBV (0.70 (0.40-1.33) vs. 0.69 (0.41-0.96) mm s-1) was unchanged compared to healthy controls. ASA infusion had similar effects on baseline CBV, LDF, and FBF in patients and controls. In eight of the control subjects the role of prostaglandins in the regulation of basal peripheral blood flow was studied before and after ASA and placebo infusion. The changes in baseline CBV, LDF, and FBF were similar after ASA and placebo infusion in healthy controls. In conclusion, in short-term IDDM patients, increased skin thermoregulatory and forearm (muscle) blood flow are probably not related to vasodilator prostaglandins. Furthermore, prostaglandins are not likely to be involved in regulating basal peripheral blood flow in healthy man.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Peripheral macro‐and microcirculation in short‐term insulin‐dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes

Houben

Kruseman

Bouhouch

et al. 1993

Eur J Clin Investigation

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“…Using a plethysmographic technique it has been demonstrated that combined treatment with Dip and aspirin in diabetics does not influence basal skin flow but prolongs the reactive hyperemia following arterial occlusion (Tooke & Tindall 1981). This enhancement of reactive hyperemia was believed to be caused by Dip, since aspirin does not influence this parameter (Tooke et al 1982). The present videophotometric capillaroscopic technique has been used to show increases in CBV and DAPA in normal subjects following the administration of nifedipine (Ostergren et al 1979).…”

Section: Discussionmentioning

confidence: 85%

Theophylline antagonizes cardiovascular responses to dipyridamole in man without affecting increases in plasma adenosine

Sollevi

Östergren

Fagrell

et al. 1984

Acta Physiologica Scandinavica

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Effects of the vasodilator dipyridamole (Dip) on plasma adenosine levels, heart rate, blood pressure and skin microcirculation were studied in 13 healthy male volunteers. Venous plasma concentrations of adenosine, catecholamines, dipyridamole and theophylline were determined by HPLC. Skin capillary blood cell velocity (CBV) was measured by videophotometric capillaroscopy in the finger nailfold. The adenosine uptake inhibitor Dip (approximately 1-3 microM in plasma) increased plasma adenosine from 0.15 +/- 0.03 to 0.29 +/- 0.03 microM (p less than 0.01) and heart rate (HR) by 13 +/- 2 beats/min (p less than 0.01) and reduced diastolic blood pressure by 6 +/- 2 mmHg (p less than 0.05). Dip did not significantly affect the skin circulation since basal CBV, digital pulse amplitude (DAPA), skin temperature and post-occlusive reactive hyperemia were unchanged. Plasma catecholamine levels were also unaffected. The adenosine receptor antagonist theophylline (45-55 microM in plasma) did not influence basal plasma catecholamine or adenosine levels, HR, blood pressure or skin microcirculation. Following theophylline Dip caused similar elevations of plasma adenosine but no changes in HR or blood pressures. Our results support the hypotheses that Dip dilates blood vessels in man by elevating endogenous adenosine and that theophylline acts as an adenosine antagonist. Under basal conditions, the skin microcirculation appears to be regulated mainly by factors other than adenosine.

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“…The peak of the blood flow on hyperemia and/or the basal values have been used to identify different populations or experimental conditions, but sometimes, as also observed in the present study, these parameters are not sensitive (Gokce et al 2001, Vogel et al 1997, Tooke et al 1982. When cyclooxygenase inhibitors such as aspirin and ibuprofen are used in experimental protocols, a reduction of the reactive hyperemia, i.e.…”

Section: Discussionmentioning

confidence: 68%

“…Most of the parameters of equation ( 1) did not show a statistical difference when the two studied groups were considered, perhaps due to individual variability and the number of the subjects in the present stage of the study. Such individual differences are believed to explain why some studies have used experimental protocols to evoke distinct vascular conditions but have not observed the expected results (Gokce et al 2001, Naylor et al 1999, Vogel et al 1997, Tooke et al 1982.…”

Section: Discussionmentioning

confidence: 99%

Assessment of characteristic of the vasomotor control dynamics based on plethysmographic blood flow measurement

Macedo¹,

Nóbrega²,

Machado³

et al. 2008

Physiol. Meas.

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Enhancing the knowledge about the characteristic of the vasomotor control can help physicians to improve the treatment of cardiovascular diseases and their consequences in people's daily activities. Vessels are generally evaluated from a static point of view, where some vascular features are obtained in a given space of time, or expressed as an average of some evaluation. The present study presents a method to assess some characteristics of the vasomotor control dynamics. Such a method is based on a mathematical description of the temporal profile of the blood flow observed during a reactive hyperemia condition induced by a protocol of 5 min of ischemia. The parameters for such a mathematical descriptive function were evaluated by searching for sensitivity to identify normal and vasomotor alterations induced by oral administration of ibuprofen (1200 mg) in ten healthy volunteers. The results indicated by the proposed mathematical description fitted appropriately experimental blood flow data (fitting-error of 0.18 ml/100 ml of tissue/min). Additionally, one parameter of the mentioned function was statistically different (P < 0.05) when one considers the normal and altered conditions of the vessel, even when the traditional peak and the basal flow values did not hint at the distinction.

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Aspirin, prostacyclin and post-occlusive reactive hyperaemia in man

Cited by 7 publications

References 7 publications

Peripheral macro‐and microcirculation in short‐term insulin‐dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes

Peripheral macro‐and microcirculation in short‐term insulin‐dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes

Theophylline antagonizes cardiovascular responses to dipyridamole in man without affecting increases in plasma adenosine

Assessment of characteristic of the vasomotor control dynamics based on plethysmographic blood flow measurement

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