1996
DOI: 10.1161/01.cir.94.1.83
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Aspirin-Stimulated Nitric Oxide Production by Neutrophils After Acute Myocardial Ischemia in Rabbits

Abstract: Our results show that myocardial ischemia/reperfusion stimulates production of NO by circulating neutrophils, an effect that was enhanced in the presence of aspirin. These results suggest a novel interpretation of the protective effect of aspirin on myocardial ischemia damage.

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Cited by 45 publications
(22 citation statements)
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“…Generally, NO can induce cell death by apoptosis in a variety of different cell types (López-Farré et al, 1996;Messmer et al, 1996). There are various biochemical and cellular mechanisms underlying NO-induced apoptosis, e.g.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, NO can induce cell death by apoptosis in a variety of different cell types (López-Farré et al, 1996;Messmer et al, 1996). There are various biochemical and cellular mechanisms underlying NO-induced apoptosis, e.g.…”
Section: Discussionmentioning
confidence: 99%
“…Thrombin also has an important role in shearinduced platelet activation and arterial thrombosis [14,[18][19][20][21]. Furthermore, the involvement of erythrocytes and leucocytes in arterial thrombus formation has been documented [22][23][24]. Thus, increasing evidence supports the concept that in vitro measurement of shear-induced platelet responses using non-anticoagulated blood may provide information that is pathophysiologically relevant to arterial thrombosis in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…6 Superoxide anion inhibits the action of NO and this inhibition is attenuated by the concomitant application of superoxide dismutase (SOD). 7,8 The endothelium also releases vasoconstrictor factors. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide generated by endothelial cells that counterbalances the vasodilating effect of NO.…”
Section: Me Et Th Ho Od Ds S:mentioning
confidence: 99%