Aspirin stimulates insulin and glucagon secretion and increases glucose tolerance in normal and diabetic subjects

Micossi, P.; Pontiroli, Antonio E.; Baron, S. H.; Tamayo, R. C.; Lengel, F.; Bevilacqua, Maurizio; Raggi, U.; Norbiato, Guido; Foa, P. P.

doi:10.2337/diabetes.27.12.1196

Cited by 41 publications

(28 citation statements)

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“…Treatment with acetylsalicylic acid produces an increase in plasma concentrations of IRI and IRG as well as a fall in BG concentrations in normal and diabetic men (2). The stimulatory action of acetylsalicylic acid has been desribed for the first phase of insulin secretion in response to iv administration of glucose (2, 4) and for arginine-induced insulin release in normal man (4).…”

Section: Discussionmentioning

confidence: 98%

“…Thus, a modification of the secretion of insulin and glucagon after the administration of acetylsalicylic acid (2) and the well known hypoglycemic effect of salicylates (3) have been attributed to the suppression of endogenous prostaglandin synthesis. As other actions of salicylates may also be responsible for these phenomena (2,4), it was of interest to investigate the arginine-induced secretion of insulin and glucagon after pretreatment with indomethacin, yet another inhibitor of the endogenous prostaglandin synthesis (5). Since a direct action of prostaglandins on the secretion of pituitary hormones is also a matter of controversy (6) we have also studied the effect of indomethacin upon the arginineinduced secretion of GH and PRL.…”

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confidence: 99%

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Unchanged Arginine-Induced Stimulation of Insulin, Glucagon, Growth Hormone, and Prolactin after Pretreatment with Indomethacin in Normal Man*

Vierhapper

Bratusch-Marrain

Waldhäusl

1980

The Journal of Clinical Endocrinology & Metabolism

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The arginine-induced release of insulin, glucagon, GH, and PRL was studied in eight normal male volunteers. Pretreatment with indomethacin (150 mg for 3 days) failed to modify the effect of arginine on the release of these hormones. As both indomethacin and acetylsalicylic acid are potent inhibitors of the endogenous prostaglandin synthesis, these results indicate that the effect of acetylsalicylic acid on insulin and glucagon secretion, as described by others, seems to be unrelated to the suppression of endogenous prostaglandin synthesis.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Unchanged Arginine-Induced Stimulation of Insulin, Glucagon, Growth Hormone, and Prolactin after Pretreatment with Indomethacin in Normal Man*

Vierhapper

Bratusch-Marrain

Waldhäusl

1980

The Journal of Clinical Endocrinology & Metabolism

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“…Thus, the reduction of cataract formation in patients with rheumatoid arthritis and diabetes receiving aspirin may have resulted from the hypoglycemic effects of this drug (18,20,22). Aspirin stimulates insulin secretion following glucose loads in normal humans and in diabetics (22). In diabetic rats salicylic acid lowers plasma glucose levels by 57.8% in 5 hrs (8).…”

Section: Discussionmentioning

confidence: 99%

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

Cotlier

1981

Int Ophthalmol

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The prevalence of cataracts is significantly lower in patients with rheumatoid arthritis receiving aspirin (mean of 2,700 mgs daily for an average of 10.4 years) as compared to the matched population not receiving aspirin. Similarly, fewer cataracts were found among a population with diabetes and rheumatoid arthritis receiving aspirin (mean of 2,340 mgs daily for an average of 8.8 years) as compared to the matched population on no aspirin. The effects of aspirin on cataract formation may result from 1) lowering of plasma tryptophan levels and increased excretion of tryptophan metabolites, 2) inhibition of aldose reductase and sorbitol formation in the diabetic lens, 3) inhibition of tryptophan or kynurenine binding to lens protein.

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“…S ODIUM salicylate and acetylsalicylate have been reported to enhance glucose-induced insulin secretion in vitro and in vivo (2)(3)(4)(5)(6)(7)(8)(9). Salicylates were proposed to exert their effects on pancreatic islet cells by inhibiting prostaglandin (PG) synthesis.…”

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confidence: 99%

The Effect of Flurbiprofen, a Potent Inhibitor of Prostaglandin Synthesis, on Insulin and Glucagon Release from Isolated Rat Pancreas^*

1984

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The influence of different levels of inhibition of prostaglandin (PG) synthesis on the release of insulin and glucagon was investigated in the basal state (5.6 mM glucose) and in response to 30-min perfusion of 16.7 mM glucose using the isolated perfused rat pancreas model. Flurbiprofen (FLR), a potent and selective inhibitor of PG synthesis, was present in the perfusate during the entire experimental period at a concentration of 10(-8), 5 X 10(-8), or 10(-6) M; control experiments were performed without the drug. Levels of immunoreactive PGE2, PGF2 alpha, insulin, and glucagon were measured in the portal venous effluent. FLR inhibited PG synthesis in a dose-related manner; PGE2 was inhibited more than PGF2 alpha. Basal and glucose-induced secretion of insulin was augmented by FLR at 5 X 10(-8) M, but was inhibited at 10(-6) M. At 10(-6) M FLR, basal glucagon secretion was inhibited; glucose-induced suppression still occurred without any potentiation. We conclude that 1) endogenous PGs modulate the secretion of insulin and glucagon; 2) divergence of the effects of low and high levels of inhibition of PG biosynthesis on insulin release may be due to altered tissue proportions of various PGs and related autacoids; and 3) the predominant effect of endogenous PGs on glucagon release is tonic stimulation.

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Aspirin stimulates insulin and glucagon secretion and increases glucose tolerance in normal and diabetic subjects

Cited by 41 publications

References 0 publications

Unchanged Arginine-Induced Stimulation of Insulin, Glucagon, Growth Hormone, and Prolactin after Pretreatment with Indomethacin in Normal Man*

Unchanged Arginine-Induced Stimulation of Insulin, Glucagon, Growth Hormone, and Prolactin after Pretreatment with Indomethacin in Normal Man*

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

The Effect of Flurbiprofen, a Potent Inhibitor of Prostaglandin Synthesis, on Insulin and Glucagon Release from Isolated Rat Pancreas^*

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Aspirin stimulates insulin and glucagon secretion and increases glucose tolerance in normal and diabetic subjects

Cited by 41 publications

References 0 publications

Unchanged Arginine-Induced Stimulation of Insulin, Glucagon, Growth Hormone, and Prolactin after Pretreatment with Indomethacin in Normal Man*

Unchanged Arginine-Induced Stimulation of Insulin, Glucagon, Growth Hormone, and Prolactin after Pretreatment with Indomethacin in Normal Man*

Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combined to diabetes

The Effect of Flurbiprofen, a Potent Inhibitor of Prostaglandin Synthesis, on Insulin and Glucagon Release from Isolated Rat Pancreas*

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Product

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The Effect of Flurbiprofen, a Potent Inhibitor of Prostaglandin Synthesis, on Insulin and Glucagon Release from Isolated Rat Pancreas^*