Aspirin Use and the Risk of Gastric Cancer: A Meta-Analysis

Yang, Ping; Zhou, Yong; Chen, Bo; Wan, Hang; Ge, Jia; Bai, Hai-Long; Wu, Xiaoting

doi:10.1007/s10620-009-0915-0

Cited by 63 publications

(57 citation statements)

References 39 publications

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“…Epidemiological studies suggest that the long-term use of NSAIDs decreases the incidence of and mortality from gastrointestinal cancers [30,31]. The principal pharmacological effects of NSAIDs are due to their ability to inhibit COX-2 and prostaglandin synthesis [32,33].…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk

Wang

Cai

Wang

et al. 2017

Clinical Infectious Diseases

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Background. Previous studies suggest that a stable end-product of prostaglandin E2, the urinary metabolite PGE-M, is associated with colorectal cancer, and 1 study of relatively small sample size found an association with gastric cancer among women. In the present study we further investigate the PGE-M, Helicobacter pylori, and gastric cancer association.Methods. The present analysis included 359 prospectively ascertained gastric cancer cases and 700 individually matched controls from the Shanghai Women's and Men's Health Studies. Urinary PGE-M was measured by a liquid chromatography/tandem mass spectrometric method. Seropositivity to 15 H. pylori recombinantly expressed fusion proteins was detected by H. pylori multiplex serology.Results. Adjusting for H. pylori, increasing PGE-M was associated with higher risk of gastric cancer (quartile 4 vs 1: odds ratio [OR], 1.76 [95% confidence interval {CI}, 1.17-2.66], P trend = .004). This association remained after excluding those diagnosed within 2 years from sample collection (OR, 1.73 [95% CI, 1.12-2.65], P trend = .007). However it was no longer present among individuals with 10 or more years of follow-up (2-4. Conclusions. In China, higher PGE-M levels may indicate an increased risk of gastric cancer independent of the risk conferred by H. pylori infection status, particularly for cancers diagnosed within 10 years of sample collection.

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Section: Discussionmentioning

confidence: 99%

A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk

Wang

Cai

Wang

et al. 2017

Clinical Infectious Diseases

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“…At the same time, we could find some mistakes about data abstracting in one meta-analysis. This also happened in the topic about the relationships between aspirin use and GC risk (Tian et al, 2010;Yang et al, 2010). One meta-analysis (Yang et al, 2010) included one RCT (Cook et al, 2005) and another PCC study (Figueroa et al, 2009) than the first one (Tian et al, 2010).…”

Section: Discussionmentioning

confidence: 98%

“…Two metaanalyses (Tian et al, 2010;Yang et al, 2010) evaluated the relationships between aspirin use and GC risk, but they were different in their ORs, as one meta-analysis included one RCT (Cook et al, 2005) and another PCC study (Figueroa et al, 2009). So the other meta analysis (Yang et al, 2010) were much more comprehensive than the first one (Tian et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors

Ying²,

Sun³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background and Objective: A comprehensive overall review of gastric cancer (GC) risk and protective factors is a high priority, so we conducted the present study. Methods: Systematic searches in common medical electronic databases along with reference tracking were conducted to include all kinds of systematic reviews (SRs) about GC risk and protective factors. Two authors independently selected studies, extracted data, and evaluated the methodological qualities and the quality of evidence using R-AMSTAR and GRADE approaches. Results: Betacarotene below 20 mg/day, fruit, vegetables, non-fermented soy-foods, whole-grain, and dairy product were GC protective factors, while beta-carotene 20 mg/day or above, pickled vegetables, fermented soy-foods, processed meat 30g/d or above, or salty foods, exposure to alcohol or smoking, occupational exposure to Pb, overweight and obesity, helicobacter pylori infection were GC risk factors. So we suggested screening and treating H. pylori infection, limiting the amount of food containing risk factors (processed meat consumption, beta-carotene, pickled vegetables, fermented soy-foods, salty foods, alcohol), stopping smoking, avoiding excessive weight gain, avoidance of Pb, and increasing the quantity of food containing protective components (fresh fruit and vegetables, non-fermented soy-foods, whole-grain, dairy products). Conclusions: The conclusions and recommendations of our study were limited by including SRs with poor methodological bases and low quality of evidence, so that more research applying checklists about assessing the methodological qualities and reporting are needed for the future.

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“…A more recent review of 14 studies looking at aspirin and gastric cancer (one RCT and 13 observational) conducted a meta-analysis and found no overall effect of aspirin (odds ratio [OR]* = 0.80, 95% CI = 0.54 to 1.19), although when analysis was restricted to three RCT or cohort studies (that is, higher quality studies) there was a significant reduction in the incidence of gastric cancer (OR* = 0.74 (95% CI = 0.63 to 0.86). 9 Although the authors of these reviews highlight certain methodological limitations, and the need to interpret the findings with caution, they do suggest a possible association between aspirin use and a reduced incidence of non-colon GI cancers.…”

Section: Aspirin and Cancer Preventionmentioning

confidence: 99%

Aspirin for prevention of cancer and cardiovascular disease

Rose¹,

Watson²,

Jenkins³

2011

Br J Gen Pract

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Aspirin Use and the Risk of Gastric Cancer: A Meta-Analysis

Abstract: This meta-analysis indicated that regular use of aspirin may be associated with reduced risk of noncardia gastric cancer, especially among Caucasians; for H. pylori-infected subjects the result was similar.

Cited by 63 publications

References 39 publications

A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk

A Prospective Study of Urinary Prostaglandin E2 Metabolite, Helicobacter pylori Antibodies, and Gastric Cancer Risk

Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors

Aspirin for prevention of cancer and cardiovascular disease

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