Asprosin, irisin, and meteorin-like protein immunoreactivity in different stages of colorectal adenocarcinoma

Uzun, M.; ILHAN, Yavuz Selim; BOZDAG, Ahmet; Yılmaz, Mustafa; Artaş, Gökhan; Kuloğlu, Tuncay

doi:10.1016/j.prp.2023.154432

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…This cytokine regulates the expression of antimicrobial peptides [ 45 ] and improves LPS-induced inflammatory responses [ 47 ]. Intriguingly, recent evidence demonstrates that Metrnl plays an oncogenic role in regulating CRC cell behavior [ 48 ] and it is produced in colorectal adenocarcinoma [ 49 ]. Based on these findings, we can hypothesize that an elevated bacterial DNA load might trigger the production of Metrnl, leading to the activation of immune mechanisms for bacterial clearance, resulting in a reduction in bacterial DNA load in the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Giacconi,

Donghia,

Arborea

et al. 2023

Microorganisms

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The gut microbiota has gained increasing attention in recent years due to its significant impact on colorectal cancer (CRC) development and progression. The recent detection of bacterial DNA load in plasma holds promise as a potential non-invasive approach for early cancer detection. The aim of this study was to examine the quantity of bacterial DNA present in the plasma of 50 patients who have CRC in comparison to 40 neoplastic disease-free patients, as well as to determine if there is a correlation between the amount of plasma bacterial DNA and various clinical parameters. Plasma bacterial DNA levels were found to be elevated in the CRC group compared to the control group. As it emerged from the logistic analysis (adjusted for age and gender), these levels were strongly associated with the risk of CRC (OR = 1.02, p < 0.001, 95% C.I.: 1.01–1.03). Moreover, an association was identified between a reduction in tumor mass and the highest tertile of plasma bacterial DNA. Our findings indicate that individuals with CRC displayed a higher plasma bacterial DNA load compared to healthy controls. This observation lends support to the theory of heightened bacterial migration from the gastrointestinal tract to the bloodstream in CRC. Furthermore, our results establish a link between this phenomenon and the size of the tumor mass.

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Section: Discussionmentioning

confidence: 99%

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Giacconi,

Donghia,

Arborea

et al. 2023

Microorganisms

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“…However, no correlation between levels of irisin and oxidative stress parameters was found [90]. Interestingly, Uzun et al reported increased levels of irisin in patients with early stages of colorectal adenocarcinoma and decreased levels in the group at the advanced stage of this tumorigenesis [91].…”

Section: Irisin and Gastrointestinal Malignanciesmentioning

confidence: 99%

The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

Pinkas,

Brzozowski

2024

Antioxidants

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Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases.

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“…More recently, it was also shown that circulating asprosin levels can act as a potential biomarker in ovarian cancer, distinguishing serous benign, serous borderline, and malignant ovarian cancers [10]. Similarly, the clinical utility of serum asprosin levels was also noted in early pancreatic cancer, whilst a significant increase in asprosin immuno-reactivity was also noted in colorectal adenocarcinoma (i.e., grade 1 vs. grade 2) [11,12].…”

Section: Introductionmentioning

confidence: 95%

In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma

Orton,

Karkia,

Mustafov

et al. 2024

Cancers

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Background: Protein Tyrosine Phosphatase Receptor Type D (PTPRD) is involved in the regulation of cell growth, differentiation, and oncogenic transformation, as well as in brain development. PTPRD also mediates the effects of asprosin, which is a glucogenic hormone/adipokine derived following the cleavage of the C-terminal of fibrillin 1. Since the asprosin circulating levels are elevated in certain cancers, research is now focused on the potential role of this adipokine and its receptors in cancer. As such, in this study, we investigated the expression of PTPRD in endometrial cancer (EC) and the placenta, as well as in glioblastoma (GBM). Methods: An array of in silico tools, in vitro models, tissue microarrays (TMAs), and liquid biopsies were employed to determine the gene and protein expression of PTPRD in healthy tissues/organs and in patients with EC and GBM. Results: PTPRD exhibits high expression in the occipital lobe, parietal lobe, globus pallidus, ventral thalamus, and white matter, whereas in the human placenta, it is primarily localised around the tertiary villi. PTPRD is significantly upregulated at the mRNA and protein levels in patients with EC and GBM compared to healthy controls. In patients with EC, PTPRD is significantly downregulated with obesity, whilst it is also expressed in the peripheral leukocytes. The EC TMAs revealed abundant PTPRD expression in both low- and high-grade tumours. Asprosin treatment upregulated the expression of PTPRD only in syncytialised placental cells. Conclusions: Our data indicate that PTPRD may have potential as a biomarker for malignancies such as EC and GBM, further implicating asprosin as a potential metabolic regulator in these cancers. Future studies are needed to explore the potential molecular mechanisms/signalling pathways that link PTPRD and asprosin in cancer.

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Asprosin, irisin, and meteorin-like protein immunoreactivity in different stages of colorectal adenocarcinoma

Cited by 5 publications

References 33 publications

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

Plasma Bacterial DNA Load as a Potential Biomarker for the Early Detection of Colorectal Cancer: A Case–Control Study

The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma

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