Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity

Gao, Huquan; Guo, Wei-Li; Wang, Qiang; Zhang, Lianqing; Zhu, Meilin; Zhu, Tianjiao; Gu, Qianqun; Wang, Wei; Li, Dehai

doi:10.1016/j.bmcl.2013.01.051

Cited by 92 publications

(63 citation statements)

References 14 publications

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“…Gliotoxin seems to be only produced in high amounts by species in section Fumigati in Aspergillus. However, the other species produce biosynthetically closely related epidithiodioxopiperazines: A. flavus, A. oryzae and A. tamarii can produce aspirochlorine = oryzachlorin (Berg et al 1976;Sakata et al 1982;Monti et al 1999;Chankhamjon et al 2014), A. terreus can produce acetylaranotin (Miller et al 1968;Cosulich et al 1968;Guo et al 2013) and A. striatus and six other species in section Nidulantes can produce emestrin (Seya et al 1985;Terao et al 1990;Kawahara et al 1994;Ooike et al 1997) (Fig. 11).…”

Section: Analogous Secondary Metabolites Are Produced In Different Sementioning

confidence: 96%

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Chemodiversity in the genus Aspergillus

Frisvad

Larsen

2015

Appl Microbiol Biotechnol

114

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Isolates of Aspergillus species are able to produce a large number of secondary metabolites. The profiles of biosynthetic families of secondary metabolites are species specific, whereas individual secondary metabolite families can occur in other species, even those phylogenetically and ecologically unrelated to Aspergillus. Furthermore, there is a high degree of chemo-consistency from isolate to isolate in a species even though certain metabolite gene clusters are silenced in some isolates. Genome sequencing projects have shown that the diversity of secondary metabolites is much larger in each species than previously thought. The potential of finding even further new bioactive drug candidates in Aspergillus is evident, despite the fact that many secondary metabolites have already been structure elucidated and chemotaxonomic studies have shown that many new secondary metabolites have yet to be characterized. The genus Aspergillus is cladistically holophyletic but phenotypically polythetic and very diverse and is associated to quite different sexual states. Following the one fungus one name system, the genus Aspergillus is restricted to a holophyletic clade that include the morphologically different genera Aspergillus, Dichotomomyces, Phialosimplex, Polypaecilum and Cristaspora. Secondary metabolites common between the subgenera and sections of Aspergillus are surprisingly few, but many metabolites are common to a majority of species within the sections. We call small molecule extrolites in the same biosynthetic family isoextrolites. However, it appears that secondary metabolites from one Aspergillus section have analogous metabolites in other sections (here also called heteroisoextrolites). In this review, we give a genus-wide overview of secondary metabolite production in Aspergillus species. Extrolites appear to have evolved because of ecological challenges rather than being inherited from ancestral species, at least when comparing the species in the different sections of Aspergillus. Within the Aspergillus sections, secondary metabolite pathways seem to inherit from ancestral species, but the profiles of these secondary metabolites are shaped by the biotic and abiotic environment. We hypothesize that many new and unique section-specific small molecule extrolites in each of the Aspergillus will be discovered.

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Section: Analogous Secondary Metabolites Are Produced In Different Sementioning

confidence: 96%

“…However, the terphenyllins and candidusins have analogous SM molecules in section Nigri: cycloleucomelon and atromentin (Hiort et al 2004) and aspulvinones in section Terrei (Gao et al 2013). All these biosynthetic families are produced via the shikimic acid pathway (Turner 1971).…”

Section: Analogous Secondary Metabolites Are Produced In Different Sementioning

confidence: 98%

Chemodiversity in the genus Aspergillus

Frisvad

Larsen

2015

Appl Microbiol Biotechnol

114

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“…are subjected to the phytotoxic and herbicidal activities [16]. The compounds produced by Aspergillus terreus include aspulvinone, an active natural product capable of inhibiting influenza An H1N1 virus [12,17] and asterriquinone, a metabolite of Aspergillus terreus found to have antitumor activity [18]. In this work, the fungi Aspergillus terreus KMBF1501 was isolated and screened from the soil samples to provide the information about the optimised fermentation conditions in order to know its ability to produce pigments with more yield and stability.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus Terreus Kmbf1501 a Potential Pigment Producer Under Submerged Fermentation

Akilandeswari

Pradeep

2017

Int J Pharm Pharm Sci

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Objective: The present study was aimed to identify the fungal isolate from soil and to understand the different optimized parameters better to facilitate the pigment production that has high yield and stability.Methods: Aspergillus sp. was isolated from Western Ghats soil by the conventional serial dilution technique and assessed as a potential pigment producer. Different broth medium such as potato dextrose broth (PDB), czapek-dox broth (CDB), malt extract broth (MEB), rose bengal broth (RBB), sabouraud dextrose broth (SDB), yeast malt extract broth (YEMB), pH (3-9), temperature (24, 27, 30, 33, 37 and 40 °C), carbon (lactose,glucose,sucrose, maltose, galactose and fructose) and nitrogen source (peptone, yeast extract, urea and inorganic nitrogen sources like potassium nitrate, ammonium chloride and sodium nitrate), mineral salts such as sodium dihydrogen phosphate (Na2H2Po4), magnesium sulphate (Mg2So4), calcium chloride (CaCl2), copper sulphate (Cu2So4), potassium dihydrogen phosphate (KH2Po4) and manganese sulphate (Mn2So4) and inoculum age (2-7 d) of the medium related to high pigment production were analysed.Results: Aspergillus terreus KMBF1501 was identified by ribosomal DNA sequencing showing 99% similarity with other Aspergillus terreus and the accession number (KX113516) was assigned. The optimum culture conditions for pigment production by Aspergillus terreus KMBF1501 was achieved at pH 5 (0.563±0.012 nm), temperature of 27 °C (0.382±0.001 nm) with glucose (0.501±0.002 nm) as carbon source, peptone (2.147±0.004 nm) as nitrogen source, Mg2SO4 (0.401±0.001 nm) as mineral salt and 4 d (0.324±0.001 nm) of inoculum age in PDB (0.761±0.006 nm). Conclusion:Aspergillus terreus KMBF1501 produced maximum pigment when cultured in modified PDB than in common PDB medium. The high concentration of the pigment can be used for various industrial purposes.

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“…The base peak ion (BPI) chromatogram and the chemical structures of the identified compounds were presented in Figures 1 and 2, respectively. morbidity and mortality [9][10][11]. So far, two classes of drugs are available for influenza infections: M2 protein blockers (adamantanes), neuraminidase (NA) and inhibitors (zanamivir and oseltamivir) [12].…”

Section: Uplc-q-tof-ms Analysismentioning

confidence: 99%

“…The influenza virus, which belongs to the Orthomyxoviridae family, is a respiratory pathogen that reproduces rapidly, mutates frequently, and occasionally crosses the species barrier with high morbidity and mortality [9][10][11]. So far, two classes of drugs are available for influenza infections:…”

Section: Introductionmentioning

confidence: 99%

Anti-Influenza Virus Activity and Constituents Characterization of Paeonia delavayi Extracts

Yang

Huang

2016

Molecules

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Paeonia delavayi, an endemic species in southwestern China, has been widely used as a traditional remedy for cardiovascular, extravasated blood, stagnated blood and female diseases in traditional Chinese medicine (TCM). However, there are no reports on the anti-influenza virus activity of this species. Here, the anti-influenza virus activity of P. delavayi root extracts was first evaluated by an influenza virus neuraminidase (NA) inhibition assay. Meantime, constituents in the active extracts were identified using ultra-high performance liquid coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and seven major identified constituents were used to further evaluate the NA inhibitory activity. The results showed that the ethyl acetate fraction (EA) and the ethanol fraction (E) of P. delavayi both presented strong NA inhibitory activity with IC 50 values of 75.932 µg/mL and 83.550 µg/mL, respectively. Twenty-seven constituents were characterized in these two active extracts by UPLC-Q-TOF-MS analysis, and seven major identified constituents exhibited high activity against the influenza virus.Among them, Benzoylpaeoniflorin (IC 50 = 143.701 µM) and pentagalloylglucose (IC 50 = 62.671 µM) exhibited the highest activity against the influenza virus, even far stronger than oseltamivir acid (IC 50 = 281.308 µM). This study indicated that P. delavayi was a strong NA inhibitor, but cell-based inhibition, anti-influenza virus activity in vivo and anti-influenza virus mechanism still need to be tested and explored.

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Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity

Cited by 92 publications

References 14 publications

Chemodiversity in the genus Aspergillus

Chemodiversity in the genus Aspergillus

Aspergillus Terreus Kmbf1501 a Potential Pigment Producer Under Submerged Fermentation

Anti-Influenza Virus Activity and Constituents Characterization of Paeonia delavayi Extracts

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