Assay of aspirin and naproxen analgesia

Mahler, D. Luke; Forrest, William H.; Brown, Colin R.; Shroff, Phyllis F.; Gordon, H. Earl; Brown, Byron W.; James, Kenneth E.

doi:10.1002/cpt197619118

Cited by 29 publications

(11 citation statements)

References 8 publications

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“…There were 17 citations [14–30] with relevant direct comparisons (18 trials) of more than one dose of aspirin. There were four comparisons of 500 and 1000 mg and 10 of 600 or 650 g and 1000 or 1200 mg. Other comparisons included doses of 200, 300, 325, 625, 650, 750 and 900 mg.…”

Section: Resultsmentioning

confidence: 99%

Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies

McQuay

Moore

2006

Brit J Clinical Pharma

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AimsEstablishing the dose-response relationship for clinically useful doses of aspirin, ibuprofen and paracetamol has been difficult. Indirect comparison from meta-analysis is compromised by too little information at some doses. MethodsA systematic review of randomized, double-blind trials in acute pain comparing different doses of aspirin, ibuprofen and paracetamol was therefore under taken. ResultsFifty trials were found. Numerical superiority of higher over lower dose was found by the original authors in 37/50 trials (74%) and statistical superiority in 11/50 (22%). Twenty-eight trials had design, quality and data reporting characteristics to allow pooling of common doses; in 3/28 (11%) of the individual trials our calculations showed statistical superiority of higher over lower dose. Pooled comparison of 1000/ 1200 mg aspirin over 500/600 mg was statistically superior, with a number-neededto-treat (NNT) for higher over lower dose of 16 (8 to > 100). Pooled comparison of 400 mg ibuprofen over 200 mg was statistically superior, with an NNT for higher over lower dose of 10 (6-23). Pooled comparison of 1000 mg paracetamol over 500 mg was statistically superior, with an NNT for higher over lower dose of 9 (6-20). ConclusionsUse of trials making direct comparison of two different doses of target drugs revealed the underlying dose-response curve for clinical analgesia.

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Section: Resultsmentioning

confidence: 99%

Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies

McQuay

Moore

2006

Brit J Clinical Pharma

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“…Studies with single 200 to 600 mg doses of naproxen have shown it to be at least as effective as single standard doses of aspirin or other standard reference analgesics in patients with moderate or severe postoperative pain resulting from orthopaedic (Ruedy & McCullough, 1973), dental (Ruedy, 1973), and other surgical procedures (Mahler, Forrest, Brown, Shroff, Gordon, Brown & James, 1976;Stetson, Robinson, Wardell & Lasagna, 1973). The need for an analgesic agent with an even faster onset of action than naproxen, however, has led to an investigation of methods to increase the speed of absorption of naproxen.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of naproxen sodium and its relationship to clinical analgesic effects.

Sevelius¹,

Runkel²,

Segre³

et al. 1980

Brit J Clinical Pharma

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1 In the first of a series of trials with naproxen sodium it was shown that patients achieved significantly earlier and higher plasma levels of naproxen when naproxen sodium was administered. 2 In a second study comparing naproxen with naproxen sodium in patients with post‐partum pain, pain intensity was consistently lower for the group receiving naproxen sodium. However, statistically significant differences were not seen until 4 to 5 h after medication. 3 A final study documented that a more frequent dosage schedule of every 6 h led to clearly higher plasma levels than those achieved with an every 8 h regimen; plasma levels did not plateau. Doses up to 1,375 mg/day were well tolerated. 4 In conclusion, naproxen sodium appears to be an improved form of naproxen for use as a analgesic agent.

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“…It is used in the treatment of adult osteo and rheumatoid arthritis [1, 2] as well as for the relief of fever [3] and moderate pain [4,5], including pain associated with dysmenorrhea [6]. Although the drug is marketed for adult use in the United States, experience in children is limited [3,7], This study was designed to develop experience regarding metabolism and excretion of the drug, to derive dosage recommendations appropriate for pediatric pa tients.…”

mentioning

confidence: 99%

Pharmacokinetics and Metabolism of Naproxen in Children

Kauffmann¹,

Bolliger²,

Wan³

et al. 1982

Dev Pharmacol Ther

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The metabolism and pharmacokinetics of orally administered naproxen were studied in 10 children aged 6-13 years. 3 patients received the drug for antipyresis and 7 for postoperative pain. The mean elimination rate constant was greater in the febrile children than the postoperative patients, 0.064 h^-1 vs. 0.051 h^-1. 71 % of total drug recovered in urine was naproxen, and 29 % was excreted as the desmethyl metabolite. 60 and 63% of naproxen and desmethyl naproxen, respectively, were excreted as conjugates. Area under the curve and fraction of dose recovered in the urine were reduced in the postoperative patients, suggesting reduced gastrointestinal absorption of the drug compared to the febrile patients.

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Assay of aspirin and naproxen analgesia

Cited by 29 publications

References 8 publications

Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies

Dose–response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies

Bioavailability of naproxen sodium and its relationship to clinical analgesic effects.

Pharmacokinetics and Metabolism of Naproxen in Children

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