ASSAY OF HUMAN LYMPHOKINES <i>IN VITRO</i>. EVIDENCE FOR A MIGRATION STIMULATION FACTOR (MStF) WHICH INTERFERES WITH THE MACROPHAGE MIGRATION INHIBITION ASSAY

Aaskov, J. G.; Anthony, Honor M.

doi:10.1038/icb.1976.54

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Migration Stimulation1

Macrophafie Migration Inhibition1

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1978

1987

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Cited by 22 publications

(2 citation statements)

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“…The mol. wt has been estimated to be between 50,000 and 250,000 [1], although our studies suggest a molecular weight lower than this. In the human system of peripheral blood leucocyte migration, stimulation or enhancement of migration has been described [67].…”

Section: Migration Stimulationmentioning

confidence: 53%

Macrophage Migration Stimulation Factor

Fox¹,

MacSween²,

Rajaraman³

1981

Scand J Immunol

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Section: Migration Stimulationmentioning

confidence: 53%

Macrophage Migration Stimulation Factor

Fox¹,

MacSween²,

Rajaraman³

1981

Scand J Immunol

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“…The technique of Aaskov and Anthony (1976) was used to measure macrophage migration. Briefly, spleen cells were packed into 10 >A capillaries (Drummond microcaps) by centrifugation at 85 p for 3 5 min.…”

Section: Macrophafie Migration Inhibitionmentioning

confidence: 99%

Cell‐mediated Immune Response to Ross River Virus in Mice: Evidence for a Defective Effector Cell Response

Aaskov

Davies

et al. 1983

Aust J Exp Biol Med

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Summary Spleen cells recovered from mice during a primary infection with Ross River virus showed a virus‐specific proliferative response when challenged in vitro. The majority of the proliferating cells were T‐lymphocytes. In contrast, there was liltle detectable migration inhibition factor produclion by these spleen cells and little or no virus‐specific cytotoxic activity. Sub‐cutaneous challenge with virus elicited a weak delayed type hypersensitivity reaction.

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Variation of macrophage migration by a factor from regional lymph node cells of breast cancer patients

Fisher

Golinger

Kelly

et al. 1978

Cancer

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Using a standard heterologous assay in which lymphokines alter guinea pig peritoneal macrophage migration, it was found that regional lymph node cells (RLNCs) from patients with primary breast cancer elaborate soluble factors which variably affect such migration. Variation of migration resulted when soluble factors employed were obtained from different nodes in the same patient as well as from nodes from different patients. Some nodes from a patient elaborated migration inhibition factors (MIF) and other migration enhancing factors (MEF). The findings are in keeping with others obtained by us relative to the variation in lymphocyte transformation and thymidine uptake by RLNCs and further emphasize that all RLNs in patients with breast cancer are not biologically similar. They lend support to our previous hypothesis that the reason why some RLNs contain metastases and others do not is more likely due to biological differences than because of anatomical happenstance, i.e., transport of tumor cells to some nodes and not to others.

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ASSAY OF HUMAN LYMPHOKINES IN VITRO. EVIDENCE FOR A MIGRATION STIMULATION FACTOR (MStF) WHICH INTERFERES WITH THE MACROPHAGE MIGRATION INHIBITION ASSAY

Cited by 22 publications

References 1 publication

Macrophage Migration Stimulation Factor

Macrophage Migration Stimulation Factor

Cell‐mediated Immune Response to Ross River Virus in Mice: Evidence for a Defective Effector Cell Response

Variation of macrophage migration by a factor from regional lymph node cells of breast cancer patients

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