Assays for Apical Constriction Using the Xenopus Model

Baldwin, Austin T.; Popov, Ivan K.; Wallingford, John B.; Chang, Chenbei

doi:10.1007/978-1-0716-2035-9_24

Cited by 3 publications

(1 citation statement)

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“…During these processes, lateral cells move toward the dorsal midline to narrow the germ layers and promote neural tube closure, while dorsal midline cells extend along the anteroposterior (AP) axis to lengthen the embryo [6]. Other asymmetric cell behaviors, such as oriented cell division and apical constriction, also make an important contribution to epithelial morphogenesis during gastrulation and neurulation [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure

Shi

2022

Cell. Mol. Life Sci.

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Gastrulation and neurulation are successive morphogenetic processes that play key roles in shaping the basic embryonic body plan. Importantly, they operate through common cellular and molecular mechanisms to set up the three spatially organized germ layers and to close the neural tube. During gastrulation and neurulation, convergent extension movements driven by cell intercalation and oriented cell division generate major forces to narrow the germ layers along the mediolateral axis and elongate the embryo in the anteroposterior direction. Apical constriction also makes an important contribution to promote the formation of the blastopore and the bending of the neural plate. Planar cell polarity proteins are major regulators of asymmetric cell behaviors and critically involved in a wide variety of developmental processes, from gastrulation and neurulation to organogenesis. Mutations of planar cell polarity genes can lead to general defects in the morphogenesis of different organs and the co-existence of distinct congenital diseases, such as spina bifida, hearing deficits, kidney diseases, and limb elongation defects. This review outlines our current understanding of non-canonical Wnt signaling, commonly known as Wnt/planar cell polarity signaling, in regulating morphogenetic movements of gastrulation and neural tube closure during development and disease. It also attempts to identify unanswered questions that deserve further investigations.

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