Assembly and Application of a Low Budget Photoreactor**

Abstract

Photochemistry is a fast growing research field and many transformations previously not accessible to chemists now have become part of an ever growing standard repertoire. The limiting factors for a photoreactor system however are the possibility to perform stirring, removal of excess heat and the irradiation with UV or visible light -all that within a secure surrounding. Systems for starters may be as expensive as several thousand Euro. Here we design and assemble a LED photoreactor using scrap and standard materials, spending less than 30 E for a LED. The system may be adjusted to any required wavelength and its assembly is shown for the use of a 400 nm LED. To demonstrate its application, we then exemplarily use the reactor in the removal of a photolabile protection group during the synthesis of a SARS-CoV-2 spike protein glycopeptide.

Comparative Evaluation of Light‐Driven Catalysis: A Framework for Standardized Reporting of Data**

“…Differences in heat and mass transport depend on the reactor type, and all these factors directly affect the (light‐driven) reactivity. Various laboratory scale reactors have recently been reported to address the challenges of comparability [85, 87, 101, 102] . Specific chemical challenges, such as enhancing mass transport, have also been addressed using specialized spinning disc or oscillatory photoreactors [103, 104] .…”

“…Various laboratory scale reactors have recently been reported to address the challenges of comparability. [85,87,101,102] Specific chemical challenges, such as enhancing mass transport, have also been addressed using specialized spinning disc or oscillatory photoreactors. [103,104] Transferring synthesis from batch to continuous operation (e.g., with plug flow or (a series of) continuously stirred photoreactors) accelerates process optimization, improves handling of multiphase reaction systems, and accelerates transfer from lab to application.…”

Vergleichende Evaluierung lichtgetriebener Katalyse: Ein Rahmenkonzept für das standardisierte Berichten von Daten**

“…Kürzlich wurde über verschiedene Reaktoren im Labormaßstab berichtet, um die Herausforderungen der Vergleichbarkeit zu bewältigen. [85,87,101,102] Spezifische chemische Herausforderungen, wie die Verbesserung des Stofftransports, wurden auch mit speziellen spinning disc-oder oszillierenden Photoreaktoren angegangen. [103,104] Die Verlagerung der Synthese vom Batch-zum kontinuierlichen Betrieb, z.…”

“…Unterschiede im Wärme‐ und Stofftransport hängen vom Reaktortyp ab, und alle diese Faktoren wirken sich direkt auf die (lichtgetriebene) Reaktivität aus. Kürzlich wurde über verschiedene Reaktoren im Labormaßstab berichtet, um die Herausforderungen der Vergleichbarkeit zu bewältigen [85, 87, 101, 102] . Spezifische chemische Herausforderungen, wie die Verbesserung des Stofftransports, wurden auch mit speziellen spinning disc ‐ oder oszillierenden Photoreaktoren angegangen [103, 104] .…”