Assembly of cationic and amphiphilic β-sheet FKF tripeptide confers antibacterial activity

Azoulay, Ziv; Aibinder, Polina; Gancz, Ayala; Moran-Gilad, Jacob; Navon-Venezia, Shiri; Rapaport, Hanna

doi:10.1016/j.actbio.2021.02.015

Cited by 22 publications

(35 citation statements)

References 63 publications

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“…Antibacterial peptides (AMPs) have broad-spectrum antibacterial properties and exhibit superior antibacterial properties against multidrug-resistant bacteria [ [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , 139 ]. Many active peptides are cationic amphiphilic peptides containing many cationic arginine, lysine, or residues, which can destroy bacterial membranes and cytoplasmic proteins and inactivate nucleic acids, resulting in bacterial inactivation and death [ 23 , 140 ].…”

Section: Natural Antibacterial Agents-incorporated Hydrogelsmentioning

confidence: 99%

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Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Hui-yuan

Lin

et al. 2022

Materials Today Bio

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Section: Natural Antibacterial Agents-incorporated Hydrogelsmentioning

confidence: 99%

“…Scientists have found that forming a composite of a self-assembling peptides and a natural polymers can improve biocompatibility [ 131 , 139 , 140 ]. Zhou et al.…”

Section: Natural Antibacterial Agents-incorporated Hydrogelsmentioning

confidence: 99%

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Hui-yuan

Lin

et al. 2022

Materials Today Bio

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“…Antimicrobial peptides (AMPs) are also employed in the formulation of hydrogels [75][76][77]. They are cationic and amphiphilic (hydrophilic and hydrophobic) α-helical peptide molecules that represent one of the first-line defences of the host against bacteria, being essential components of the innate immune system in various species, including humans, animals and plants.…”

Section: Antibacterial Actionmentioning

confidence: 99%

Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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“…The widespread use of antibiotics has emerged severe antibiotic resistance and multidrug resistance in the past decades. [ 27–29 ] Metal and metallic oxide nanoparticles including silver (Ag) NPs and zinc oxide (ZnO) NPs, [ 30 ] and other nanoparticles presented excellent antibacterial properties and could maintain long‐period antibacterial activities, but the toxicity and biodegradability limited their further applications. Biological extracts often exhibited inherent antibacterial ability, such as antibacterial peptides (AMPs) and natural polysaccharides, which have been extensively researched due to their biodegradability, biocompatibility, and abundance in nature.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Force Induced Self‐Assembly of Chinese Herbal Hydrogel with Synergistic Effects of Antibacterial Activity and Immune Regulation for Wound Healing

Chen

Zhang

Qiu

et al. 2022

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Skin wounds, especially infected chronic wounds, have attracted worldwide attention due to the high prevalence and poor treatment outcomes. Hydrogel dressings with antibacterial ability and immune regulation property are urgently required. Herein, inspired by the grinding treatment of traditional Chinese medicine, mechanical force is introduced to promote the effective molecular collision and accelerate the self‐assembly of chitosan (CS) and puerarin (PUE) for fabricating Chinese‐herb‐based hydrogels. The antibacterial rate of CS@PUE (C@P) hydrogel is more than 95%, and the wound closed rate is twice that of the control group. Interestingly, the rational design of C@P hydrogels with different PUE ratios enables a refined control over hydrogel formation, nanofiber appearance, viscoelastic, physicochemical, and biological properties. The extraordinary antibacterial ability of C@P hydrogels may originate from the nanofiber structure and the improved zeta potential on account of the orientation of amino groups in CS . Thus, the synergistically antibacterial and immune regulation properties of C@P hydrogels kill bacteria and relieve inflammation in the wound bed, ensuring the anti‐infection effect, and boosting wound healing. In addition to providing a universal mechanosynthesis of PUE‐based hydrogel for wound healing, this finding is expected to increase the attention paid to Chinese herbal medicines in the construction of biomaterials.

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Assembly of cationic and amphiphilic β-sheet FKF tripeptide confers antibacterial activity

Cited by 22 publications

References 63 publications

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Nanomaterials in Skin Regeneration and Rejuvenation

Mechanical Force Induced Self‐Assembly of Chinese Herbal Hydrogel with Synergistic Effects of Antibacterial Activity and Immune Regulation for Wound Healing

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