Assess the Efficacy of Combination Therapy for Fungal Otitis Externa

Abstract

Purpose: assess the efficacy of sodium bicarbonate solution and perisone cream combination therapy in the treatment of fungal otitis externa. Methods: The experimental group was administered a combination of sodium bicarbonate solution and perisone cream, whereas the control group was administered saline and perisone cream. The cleanliness of the external ear canal was assessed using endoscopic Visual Analog Scale（Visual Analog Scale）scores before and after the intervention. Statistical analysis was conducted to evaluate and compare the VAS scores at various time points and levels, with the goal of determining the effectiveness of combining sodium bicarbonate solution with perisone cream for the treatment of fungal otitis externa. Results: The experimental group exhibited a higher level of treatment efficacy than the control group did. Notably, significant differences in VAS scores were observed between the two groups on the 4th day (t = -4.391, p < 0.001) and the 7th day (t = -5.754, p < 0.001), indicating consistent superiority of the therapeutic effect in the experimental group. Specifically, at the end of the 7th day of treatment, the experimental group demonstrated significantly better efficacy than the control group in terms of the mild score (t = -5.101, p < 0.001). Conclusions: The use of sodium bicarbonate solution along with perisone cream has proven to be highly effective in treating fungal otitis externa. This underscores the importance of expanding the adoption of this therapeutic approach, highlighting its potential for widespread application.