Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma

Birau, Amalia; Ceauşu, Raluca Amalia; Cimpean, Anca Maria; Gaje, Pușa Nela; Raica, Marius; Olariu, Teodora

doi:10.3892/ol.2012.893

Cited by 30 publications

(24 citation statements)

References 16 publications

(16 reference statements)

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“…The vascular convergence sign is a crucial indicator of malignancy. Angiogenesis is essential for tumor growth and metastasis . As vascular endothelial growth factor is synthesized continuously and excessively in tumors, vascular endothelial cells proliferate during vessel formation and tumor vessels remain immature .…”

Section: Discussionmentioning

confidence: 99%

“…23,24 As vascular endothelial growth factor is synthesized continuously and excessively in tumors, vascular endothelial cells proliferate during vessel formation and tumor vessels remain immature. 24,25 The immature tumor vessels are highly permeable, which causes the edema of the tumor tissue. 24 This may explain the ground-glass density of the nodule.…”

Section: Vascular Convergence Signmentioning

confidence: 99%

“…24,25 The immature tumor vessels are highly permeable, which causes the edema of the tumor tissue. 24 This may explain the ground-glass density of the nodule. 9 In our studied sample, the vessels did not adjoin or contact the edge of the nodule but rather converged on the nodule.…”

Section: Vascular Convergence Signmentioning

confidence: 99%

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Multi‐slice computed tomography characteristics of solitary pulmonary ground‐glass nodules: Differences between malignant and benign

Wang

Tang

et al. 2015

Thoracic Cancer

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BackgroundGround‐glass nodules (GGNs), which are possible precursors of lung cancer, attract increasing attention. Many studies have attempted to identify the characteristic imaging features of GGNs for their qualitative diagnosis; however, the comprehension of GGNs remains controversial. We performed this study to identify imaging characteristics helpful to the differential diagnosis of solitary GGNs.MethodsWe retrospectively evaluated 112 solitary GGNs resected from 112 patients, pathologically examined after surgical resection. Imaging features of the GGNs, such as size, shape, a solid component, lobulation, spiculation, vascular convergence sign, pleural tag, and air cavity density, were assessed. Differences between malignant and benign nodules were analyzed using binary logistic regression analysis.ResultsOf the 112 GGNs, 82 were malignant and 30 were benign. A solid component, vascular convergence sign, and a larger diameter were risk factors for malignancy, with a sensitivity, specificity, and accuracy of 93.9%, 60.0%, and 84.8%, respectively. Lobulation, spiculation, air cavity densities, and pleural tags were also important indicators of malignancy, with positive predictive values of 93.5%, 83.3%, 91.7%, and 87.2%, respectively.Conclusion GGNs with a solid component, vascular convergence sign, and a larger diameter are highly suggestive of malignancy. The possibility of a neoplasm should also be considered in the case of GGNs that show lobulation, spiculation, air cavity densities, or pleural tags. To obtain a comprehensive and accurate analysis of the nodules, three‐dimensional reconstruction is highly recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Vascular Convergence Signmentioning

confidence: 99%

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Multi‐slice computed tomography characteristics of solitary pulmonary ground‐glass nodules: Differences between malignant and benign

Wang

Tang

et al. 2015

Thoracic Cancer

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“…Angiogenesis, the formation of new blood vessels, is essential for tumor growth and metastasis . Vascular endothelial cells are proliferating during immature tumor vessel formation as a result of the continuous and excessive synthesis of vascular endothelial growth factor in cancer tissue . The immature vascularity displays higher microvessel density values or changes in vascular diameter and expansion configuration.…”

Section: Discussionmentioning

confidence: 99%

Analysis of pre‐invasive lung adenocarcinoma lesions on thin‐section computerized tomography

Xing¹,

Jiang

et al. 2014

Clinical Respiratory J

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“…Microvascular density was consistently higher in adenocarcinoma than in squamous NSCLC (13)(14)(15), and was variable in large cell NSCLC (13,14). As visualized by narrow band imaging videobronchoscopy, dotted blood vessels (short capillary loops visible as pinpoint dots) were more common in adenocarcinoma than in squamous NSCLC and were not observed in large cell NSCLC.…”

Section: Introductionmentioning

confidence: 82%

Exploring the Benefit/Risk Associated with Antiangiogenic Agents for the Treatment of Non–Small Cell Lung Cancer Patients

Kurzrock

2017

Clinical Cancer Research

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Following the approval of bevacizumab, an antibody targeting VEGF-A, for advanced non-squamous non-small cell lung cancer (NSCLC) in 2006, intensive efforts were put into the clinical development of antiangiogenic agents for NSCLC. Currently, the other antiangiogenic agents approved for NSCLC are ramucirumab, a VEGF receptor-2 (VEGFR-2)-targeting antibody indicated for both squamous and non-squamous NSCLC in the United States, and nintedanib, an anti-VEGFR-1/2/3, platelet-derived growth factor receptor-a/b, fibroblast growth factor receptor-1/2/3 angiokinase inhibitor indicated for adenocarcinoma of the lung in the European Union. Many other antiangiogenic agents are being evaluated in phase III trials for NSCLC, including aflibercept, sunitinib, sorafenib, cediranib, and vandetanib. Although many of the same signaling pathways are targeted by these novel agents, mixed efficacy results have been observed in these trials. Moreover, safety issues have raised concerns about using antiangiogenic agents in this patient population, and fatal bleeding events have been reported. Importantly, although no biomarker has yet been validated for antiangiogenic agents in NSCLC, biomarkers that show potential include circulating levels of short VEGF-A isoforms, expression of neuropilin-1 and VEGFR-1 in tumors and plasma, genetic variants in VEGF-A and VEGFR, and tumor protein p53 mutations (with the latter having been shown to correlate with increased levels of VEGF-A transcripts). This review provides an overview of the clinical benefit and risk associated with the use of antiangiogenic agents for NSCLC, and summarizes the research to date on the identification of predictive biomarkers for antiangiogenic therapies.

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Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma

Cited by 30 publications

References 16 publications

Multi‐slice computed tomography characteristics of solitary pulmonary ground‐glass nodules: Differences between malignant and benign

Multi‐slice computed tomography characteristics of solitary pulmonary ground‐glass nodules: Differences between malignant and benign

Analysis of pre‐invasive lung adenocarcinoma lesions on thin‐section computerized tomography

Exploring the Benefit/Risk Associated with Antiangiogenic Agents for the Treatment of Non–Small Cell Lung Cancer Patients

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