2021
DOI: 10.1053/j.ajkd.2020.08.005
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Assessing Acid-Base Status in Patients With CKD: Does Measurement of Blood pH Matter?

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Cited by 8 publications
(8 citation statements)
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“…The possible explanation could be firstly, the more rapid CKD progression which has been shown to occur in black patients even early in their CKD stages (16, 28) and secondly, diet where replacement of traditional diets with contemporary/ western foods which contain mainly animal proteins, less vegetables and low intake of fruits might increase CKD patients’ dietary acid load (29, 42-45). Patients with low serum bicarbonate levels were 2-fold more likely to have advanced CKD, as reported also in other studies (14, 15). The prevalence of anaemia was 46.4 % in advanced CKD, including 16.6 % who had low transferrin levels, while 25.9 % of the patients with early CKD had anemia.…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…The possible explanation could be firstly, the more rapid CKD progression which has been shown to occur in black patients even early in their CKD stages (16, 28) and secondly, diet where replacement of traditional diets with contemporary/ western foods which contain mainly animal proteins, less vegetables and low intake of fruits might increase CKD patients’ dietary acid load (29, 42-45). Patients with low serum bicarbonate levels were 2-fold more likely to have advanced CKD, as reported also in other studies (14, 15). The prevalence of anaemia was 46.4 % in advanced CKD, including 16.6 % who had low transferrin levels, while 25.9 % of the patients with early CKD had anemia.…”
Section: Discussionsupporting
confidence: 85%
“…In addition to the known risk factors for advanced CKD, which are age, male sex, black race, arterial hypertension and proteinuria, other modifiable factors including medications (traditional and herbal), hyperuricemia, hyperlipidemia, elevated phosphate levels, heart failure and anemia are common in CKD at later stages (11)(12)(13). Metabolic acidosis increases with worsening eGFR, with prevalence of around 40% among patients with CKD stage 4 and it is associated with rapid CKD progression (14)(15)(16). Anemia is common in CKD and is frequently associated with poor outcomes, including increased cardiovascular risks, hospitalization, decreased quality of life and increased risk of mortality (17)(18)(19).…”
Section: Introductionmentioning
confidence: 99%
“…There is a theoretical direct association between severity of the acid state and risk of poor clinical outcomes. 2 Studying this relationship is challenging because identifying eubicarbonatemic acidosis is not straightforward and systemic pH is not routinely measured in clinical practice or research protocols. Consequently, most research studies define metabolic acidosis as a serum bicarbonate <22 meq/L in individuals with CKD, which is how the term will be used here.…”
Section: Introductionmentioning
confidence: 99%
“…An immediate consequence of this model would be the need to treat acidosis with alkali equivalents at early stages of kidney disease and before the occurrence of overt systemic acidosis to delay further progression of kidney disease. The implementation of a more holistic assessment of the metabolic acidosis of CKD may need to take into consideration multiple parameters, such as urinary citrate and ammonium, blood pH, serum HCO 3 − (or total CO 2 ) and, in the future, other new early diagnostic markers or the direct measurement of tissue pH [ 18 ].…”
Section: Introductionmentioning
confidence: 99%