The purpose of the present study was to determine if individuals with autism spectrum disorder (ASD) display a unique pattern of responses on the Personality Assessment Inventory-Adolescent (PAI-A). Twenty adolescents between ages 12 and 18 completed the PAI-A, and their scores were compared to matched community and clinical samples from the standardization sample of the PAI-A. Results of a profile analysis indicated the ASD group displayed unique scale elevations, which may help clarify the interpretive quality of the PAI-A with individuals with autism. Clinicians and school psychologists should be aware of this research when selecting tools to evaluate adolescents with ASD. K E Y W O R D S adolescents, autism spectrum disorder, PAI-A Autism spectrum disorder (ASD) is a pervasive developmental disorder with deficits in verbal and nonverbal communication, social interactions, and restricted, repetitive patterns of behavior, interests, or activities (American Psychiatric Association [APA], 2013). The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (APA, 2013) provides two core symptoms: deficits in social communication and social interactions, such as nonverbal communication, metaphorical language, emotional regulation, understanding other's mental states, and understanding the rules of various social environments (Peterson et al., 2012), and restricted and repetitive behaviors and interests, such as selfstimulation or highly restricted interests. These symptoms vary across the lifespan (Hedges et al., 2018; Shattuck et al., 2007) requiring clinicians to be aware of appropriate assessment practices for various developmental stages.