Assessing antibiotic residues in sediments from mangrove ecosystems: A review

Mesa-Ramos, Liber; Palacios, Oskar A.; Adame-Gallegos, Jaime Raúl; Chávez-Flores, David; Nevárez-Moorillón, Guadalupe Virginia

doi:10.1016/j.marpolbul.2024.116512

Cited by 1 publication

(1 citation statement)

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“…L. monocytogenes is usually susceptible to a wide range of antibiotics in human and veterinary medicine, and the administration of penicillin, ampicillin, and gentamicin is used as the first choice ( Arslan and Ozdemir, 2020 ). The abuse or overuse of antibiotics has led to a rapid increase in the prevalence of antibiotic-resistant bacteria ( Mesa-Ramos et al, 2024 ). Although current antibiotic strategies are still effective options for the treatment of listeriosis ( Kumaraswamy et al, 2018 ), the emergence of multidrug-resistant L. monocytogenes isolates from river water, traditionally consumed food products, and human clinical specimens has been documented since the isolation of the first multiresistant strain of L. monocytogenes in France in 1988 ( Poyart-Salmeron et al, 1990 ; Harakeh et al, 2009 ; Soni et al, 2013 ), and the prevalence rate is increasing in China and other countries ( Lachtara et al, 2023 ; Zhang et al, 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Subinhibitory concentrations of glabridin from Glycyrrhiza glabra L. reduce Listeria monocytogenes motility and hemolytic activity but do not exhibit antimicrobial activity

Liao,

Yu,

Guo

et al. 2024

Front. Microbiol.

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Increases in the virulence and survival of some pathogens in the presence of subinhibitory concentrations of antibiotics have been reported. However, research on the effects of subinhibitory concentrations of antimicrobial substances derived from traditional Chinese medicine on pathogens is still insufficient. Glabridin is a well-known active isoflavone found in licorice roots that possesses a wide range of biological activities. Therefore, in this study, Listeria monocytogenes (L. monocytogenes) exposed to subinhibitory concentrations of glabridin was used as the research object. The minimum inhibitory concentration (MIC) was determined for L. monocytogenes. We investigated the impacts of subinhibitory concentrations of glabridin on the morphology, motility, biofilm formation, adherence, and survival of L. monocytogenes. The results indicated that the MIC of glabridin for L. monocytogenes was 31.25 μg/mL. At 1/8, 1/4, or 1/2 of the MIC, glabridin did not affect the growth, morphology, flagellar production, or biofilm formation of L. monocytogenes. However, subinhibitory concentrations of glabridin inhibited bacterial swimming and swarming motility and decreased the hemolytic activity of L. monocytogenes. Glabridin reduced the hemolytic activity of L. monocytogenes culture supernatants. The results also showed that subinhibitory concentrations of glabridin had no toxic effect on RAW264.7 cells but decreased the intracellular growth of L. monocytogenes in RAW264.7 cells. Furthermore, subinhibitory concentrations of glabridin triggered ROS production but did not induce MET formation in macrophages. In addition, glabridin did not enhance the capacity of L. monocytogenes to trigger METs or the extracellular killing of macrophages by METs. Thus, we conclude that subinhibitory concentrations of glabridin reduce L. monocytogenes motility and hemolytic activity but do not exhibit antimicrobial activity. Glabridin could be an interesting food additive as a bacteriostatic agent with anti-Listeria activity.

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