The use of remotely piloted unmanned aircraft systems/vehicles (UAS/UAV or drones) increases dramatically in recent years. This paper discusses the use of multiple-input and multiple-output (MIMO) technologies in cellular (i.e., LTE) based small UAS (sUAS) communications. More specifically, we will first provide background information about this work, followed by a review of state-of-the-art. Then, we will discuss the benefits of MIMO technologies and propose practical MIMO configurations (e.g., the type, size and number of antennas) that are suitable for NASA's sUAS research and operations. Finally, the design tradeoff among multiplexing, diversity, and interference/jamming cancellation will also be discussed.