2024
DOI: 10.1111/jgs.19241
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Assessing causality in deprescribing studies: A focus on adverse drug events and adverse drug withdrawal events

Xiaojuan Li,
Elizabeth A. Bayliss,
M. Alan Brookhart
et al.

Abstract: Generating real‐world evidence about the effect of medication discontinuation or dose reduction on outcomes, such as reduction of adverse drug effects (ADE; intended benefit) and occurrence of adverse drug withdrawal events (ADWE; unintended harm), is crucial to informing deprescribing decisions. Determining the causal effects of deprescribing is difficult for many reasons, including lack of randomization in real‐world study designs and other design and measurement issues that pose threats to internal validity… Show more

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