Assessing clinical probability of organic disease in patients with involuntary weight loss: a simple score

Bilbao-Garay, J; Barba, Raquel; Losa-García, Juan Emilio; Martı́n, H; Casasola, G. García de; Castilla, Virgilio; González-Anglada, I.; Espinosa, Arellano; Guijarro, Carlos

doi:10.1016/s0953-6205(02)00032-8

Cited by 42 publications

(31 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…24 The incidence of unintentional weight loss in clinical studies involving adults seeking health care varies from 1.3% to 8%, depending on the setting and definition of weight loss. 1,3,4,25 There is also a difference in rates between clinical and epidemiologic studies, probably because most patients with weight loss present within a year of onset of their clinical symptoms.…”

Section: How Common Is Weight Loss?mentioning

confidence: 99%

“…1,3,29 A careful history may elicit localizing symptoms (e.g., changes in defecation frequently imply involvement of the gastrointestinal tract) that may guide further investigations in almost half of patients. 4,29 All elderly patients with weight loss should undergo screening for dementia and depression 30 by using instruments such as the MiniMental Status Examination 49 and the Geriatric Depression Scale 50 respectively. Specific features on physical examination, such as cachexia, lymphadenopathy or palpable masses, may suggest a physical cause of weight loss (e.g., malignant disease).…”

Section: Optimal Clinical Approach To Weight Lossmentioning

confidence: 99%

“…It is associated with increased mortality, which can range from 9% to as high as 38% within 1 to 2.5 years after weight loss has occurred. 1,3,4 Frail elderly people, 5 people with low baseline body weight, [5][6][7] and elderly patients recently admitted to hospital are particularly susceptible to increased mortality. 8,9 Weight loss is also associated with an increased risk of in-hospital complications, 10,11 a decline in activities of daily living or physical function, 12,13 higher rates of admission to an institution 2,8 and poorer quality of life.…”

mentioning

confidence: 99%

See 2 more Smart Citations

An approach to the management of unintentional weight loss in elderly people

Alibhai

Greenwood²,

Payette³

2005

Canadian Medical Association Journal

234

143

View full text Add to dashboard Cite

UNINTENTIONAL WEIGHT LOSS, or the involuntary decline in total body weight over time, is common among elderly people who live at home. Weight loss in elderly people can have a deleterious effect on the ability to function and on quality of life and is associated with an increase in mortality over a 12-month period. A variety of physical, psychological and social conditions, along with age-related changes, can lead to weight loss, but there may be no identifiable cause in up to one-quarter of patients. We review the incidence and prevalence of weight loss in elderly patients, its impact on morbidity and mortality, the common causes of unintentional weight loss and a clinical approach to diagnosis. Screening tools to detect malnutrition are highlighted, and nonpharmacologic and pharmacologic strategies to minimize or reverse weight loss in older adults are discussed.

show abstract

Section: How Common Is Weight Loss?mentioning

confidence: 99%

Section: Optimal Clinical Approach To Weight Lossmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

An approach to the management of unintentional weight loss in elderly people

Alibhai

Greenwood²,

Payette³

2005

Canadian Medical Association Journal

234

143

View full text Add to dashboard Cite

show abstract

“…Unintentional weight loss, a complex and frequent syndrome [9], had devastating consequences in elder people. The prominent adverse health outcome was mortality.…”

Section: Introductionmentioning

confidence: 99%

“…Retrospective record review showed that elder people whose weight lost more than 5% within one month were 4.6 times more likely to die within 1 year [13]. After weight loss occurred, mortality could be as high as 16% during the first year [9].…”

Section: Introductionmentioning

confidence: 99%

The prevalence time trend and risk factors of weight loss among the Chinese elder people over the period from 2011-2013

Ouyanga¹,

Suna²

2017

Gen Int Med Clin Innov

View full text Add to dashboard Cite

Accelerated Weight Loss May Precede Diagnosis in Alzheimer Disease

2006

View full text Add to dashboard Cite

To determine the association of weight loss and the onset of dementia of the Alzheimer type (DAT) and to characterize the rate of weight change over time in older adults (aged 65-95 years) who develop DAT vs those who remain without dementia.Design: Rates of weight change were investigated in older adult research participants (N = 449) who were enrolled as control subjects without dementia and followed up longitudinally (6 years on average) at the Alzheimer's Disease Research Center, Washington University School of Medicine. Some individuals (n = 125) eventually developed DAT; the others (n = 324) remained without dementia. Body weight was measured at each annual assessment. Piecewise linear regression and random effects models were used to test longitudinal rates of weight change between the groups.Results: Participants without dementia lost about 0.6 lb per year. For those individuals who developed DAT, about 1 year before the detection of DAT, the rate of weight loss doubled (1.2 lb per year). As a group, participants who eventually developed DAT weighed less (about 8 pounds) at study enrollment (ie, when they did not have dementia) than participants who remained without dementia.Conclusions: Aging with and without DAT is associated with weight loss; however, weight loss may accelerate before the diagnosis of DAT. Specific factors contributing to weight loss are unknown, but these data suggest they operate before the development of DAT. Hence, weight loss may be a preclinical indicator of Alzheimer disease.

show abstract

Assessing clinical probability of organic disease in patients with involuntary weight loss: a simple score

Cited by 42 publications

References 10 publications

An approach to the management of unintentional weight loss in elderly people

An approach to the management of unintentional weight loss in elderly people

The prevalence time trend and risk factors of weight loss among the Chinese elder people over the period from 2011-2013

Accelerated Weight Loss May Precede Diagnosis in Alzheimer Disease

Contact Info

Product

Resources

About