Assessing Effective Practices and Barriers to Creating School and Community Partnerships for a Sudden Cardiac Death Prevention Program: A National Project ADAM® study

Malloy-Walton, Lindsey; Gopineti, Lalitha; Thompson, Alison J.; Vetter, Victoria L.; Batlivala, Sarosh P.

doi:10.1016/j.acap.2022.09.023

Cited by 2 publications

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Global awareness of antigenic peptides – Unraveling the impact on sickle cell anemia patients in the presence of pathogens: A narrative review

Obeagu

2024

Medicine

View full text Add to dashboard Cite

Sickle cell anemia (SCA) is a genetic blood disorder characterized by the production of abnormal hemoglobin S (HbS), leading to sickle-shaped red blood cells and various complications, including increased susceptibility to infections. The presence of antigenic peptides, short amino acid sequences derived from pathogens or altered self-proteins, plays a crucial role in immune responses. This review explores the global awareness of antigenic peptides, their role in immune responses in SCA patients, and the challenges and opportunities in managing infections within this vulnerable population. Antigenic peptides are central to the adaptive immune response, facilitating the recognition and elimination of pathogens by T-cells. In SCA, altered antigen presentation and impaired T-cell responses due to chronic inflammation, functional asplenia, and ongoing hemolysis contribute to increased susceptibility to infections. Pathogens such as Streptococcus pneumoniae and Haemophilus influenzae pose significant risks to SCA patients, highlighting the importance of robust immune responses mediated by antigenic peptides. Strategies such as vaccination and immunotherapy aim to enhance immune function by targeting specific antigenic peptides, thereby reducing infection rates and improving patient outcomes. Advances in genomics and proteomics offer insights into individual variations in antigen presentation and immune responses, guiding the development of tailored therapeutic interventions. Global collaborations are essential to address disparities in healthcare access and implement effective preventive measures, ensuring equitable outcomes for SCA patients worldwide.

show abstract

Global awareness of antigenic peptides – Unraveling the impact on sickle cell anemia patients in the presence of pathogens: A narrative review

Obeagu

2024

Medicine

View full text Add to dashboard Cite

show abstract

Triggers of Sudden Cardiac Arrest in Youth

Warneryd,

Chand,

Lemma

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Exercise is considered a primary trigger for sudden cardiac arrest (SCA) in youth. We hypothesized that other factors have important associations. Methods During 2011–2012 and 2019–2020, we surveyed Parent Heart Watch members with children who had experienced sudden cardiac arrest or sudden cardiac death for 1) demographics; 2) pre-sudden cardiac arrest symptoms, evaluation, diagnoses; 3) family history; 4) medications, substances; 5) activity; 6) circumstances; and 7) post-sudden cardiac arrest diagnoses. Results 82 responses (~ 60% of members), 23.2% with surviving children. Mean age sudden cardiac arrest, 17.2 (4.5) years, median, 16 years; range, 5–30 years; male, 75%. Race/ethnicity: white, 81.0%; Black, 3.8%; Hispanic, 5.1%; Native American, 2.5%; >1 race, 7.6%. Family history of sudden cardiac arrest < 50 years, 17.1%. Prior cardiovascular symptoms: exercise fatigue, 30.8%; chest pain, 60.3%; palpitations, 16.7%; ≥1fainting episode, 19.2%; shortness of breath, 19.2%; upset, 9.0%. Prior (10.5%) and post (63.2%) cardiac diagnoses; activity-related, 60.5%; recent flu-like illness, 25.0%. Medications/substances including caffeine, energy drinks, alcohol and tobacco consumed prior to arrest, 57.9%. Arrest witnessed, 72.4%; fifteen events in location with an automated external defibrillator (AED) - survival, 47% when AED present. Conclusions Symptoms of sudden cardiac arrest are common but often ignored and not medically evaluated or treated. While activity was frequently associated with SCA, other important triggers of SCA appear to be medications and substances, often in the presence of underlying and frequently undiagnosed heart conditions, present in over half of cases. Potential triggers of sudden cardiac arrest include activity, medications and substances, and intercurrent illnesses.

show abstract

Assessing Effective Practices and Barriers to Creating School and Community Partnerships for a Sudden Cardiac Death Prevention Program: A National Project ADAM® study

Cited by 2 publications

References 13 publications

Global awareness of antigenic peptides – Unraveling the impact on sickle cell anemia patients in the presence of pathogens: A narrative review

Global awareness of antigenic peptides – Unraveling the impact on sickle cell anemia patients in the presence of pathogens: A narrative review

Triggers of Sudden Cardiac Arrest in Youth

Contact Info

Product

Resources

About