Assessing farmer's exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study

Kumar, Dileshwar; Sinha, Sukesh Narayan; Sangaraju, Rajendra; Sharma, Kanika

doi:10.1016/j.scitotenv.2023.164429

Cited by 19 publications

(7 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum levels of p,p′-DDE (Median: 2141.82 ng/g lipids) in the elderly exceeded those observed in the adult populations of NHANES, Canada, and various cities in China (range: 203.00–680.50 ng/g lipids). ,− DDTs, recognized as highly fat-soluble organic compounds, exhibited a half-life of 6 years for DDTs and up to 8.6 years for p,p′-DDE . Despite DDTs being listed as POPs subject to control, historical residues continue to be released into the environment unabated. − China, as a developing country, extensively produced and used DDT in the past, increasing exposure to DDT and its metabolites − Moreover, numerous studies have demonstrated that, owing to the bioaccumulation of persistent chemicals and the diminished efficiency of hepatic metabolism in the elderly, this demographic group experienced the highest exposures compared to other age groups. − Our findings offered valuable insights into the prioritization of environmental chemicals, particularly DDTs, deserving attention in the elderly population.…”

Section: Discussionmentioning

confidence: 95%

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA’s ToxCast Database

Wang,

Huang

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

In line with the "healthy aging" principle, we aim to assess the exposure map and health risks of environmental chemicals in the elderly. Blood samples from 918 elderly individuals in Wuhan, China, were analyzed using the combined gas/liquid-mass spectrometry technology to detect levels of 118 environmental chemicals. Cluster analysis identified exposure profiles, while risk indexes and bioanalytical equivalence percentages were calculated using EPA's ToxCast database. The detection rates for 87 compounds exceeded 70%. DEHP, DiBP, naphthalene, phenanthrene, DnBP, pyrene, anthracene, permethrin, fluoranthene, and PFOS showed the highest concentrations. Fat-soluble pollutants varied across lifestyles. In cluster 2, which was characterized by higher concentrations of fat-soluble substances, the proportion of smokers or drinkers was higher than that of nonsmokers or nondrinkers. Pesticides emerged as the most active environmental chemicals in peroxisome proliferator-activated receptor gamma antagonist, thyroid hormone receptor (TR) antagonist, TR agonist, and androgen receptor (AR) agonist activity assays. Additionally, PAEs and polycyclic aromatic hydrocarbons played significant roles as active contaminants for the corresponding targets of AR antagonists and estrogen receptor alpha. We proposed a list of priority pollutants linked to endocrinedisrupting toxic effects in the elderly, which may provide the groundwork for further research into environmental etiology.

show abstract

Section: Discussionmentioning

confidence: 95%

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA’s ToxCast Database

Wang,

Huang

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Other potentially exposed cells (i.e., from the skin, lungs, and kidneys) should be included to assess the potential relevance of the present findings. In addition, biomonitoring studies are crucial in the future to evaluate the real level of exposure for people in daily life or after incidents in the handling of fungicide preparations [39]. Finally, special attention should be given to associations of fungicides.…”

Section: Discussionmentioning

confidence: 99%

Impact of Exposure to Pyraclostrobin and to a Pyraclostrobin/Boscalid Mixture on the Mitochondrial Function of Human Hepatocytes

Carbone,

Mathieu,

Vandensande

et al. 2023

Molecules

View full text Add to dashboard Cite

Fungicides are widely used in agriculture for crop protection. Succinate dehydrogenase inhibitors (SDHIs) and strobilurins inhibit mitochondria electron transport chain (ETC) in fungi, by blocking complex II and complex III, respectively. Questions regarding their selectivity of action for fungi have been raised in the literature, and we previously showed that boscalid and bixafen (SDHIs) alter the mitochondrial function of human hepatocytes. Here, we analyzed the impact of the exposure of human hepatocytes to pyraclostrobin, a fungicide belonging to the class of strobilurins. Using electron paramagnetic resonance (EPR), we observed a decrease in oxygen consumption rate (OCR) and an increase in mitochondrial superoxide levels after 24 h exposure to 0.5 µM concentration. As a consequence, the content in ATP amount in the cells was reduced, the ratio reduced/oxidized glutathione was decreased, and a decrease in cell viability was observed using three different assays (PrestoBlue, crystal violet, and annexin V assays). In addition, as SDHIs and strobilurins are commonly associated in commercial preparations, we evaluated a potential “cocktail” toxic effect. We selected low concentrations of boscalid (0.5 µM) and pyraclostrobin (0.25 µM) that did not induce a mitochondrial dysfunction in liver cells when used separately. In sharp contrast, when both compounds were used in combination at the same concentration, we observed a decrease in OCR, an increase in mitochondrial superoxide production, a decrease in the ratio reduced/oxidized glutathione, and a decrease in cell viability in three different assays.

show abstract

“…Occupational exposure to pesticides has been linked to a variety of adverse health effects, spanning noncommunicable diseases such as cancer, Parkinson’s disease, Alzheimer’s disease, as well as conditions like obesity and diabetes. In this context, extensive studies across various labor-related sectors are imperative to fully understand the scope and impact of these associations ( 211 , 212 ).…”

Section: Applicationsmentioning

confidence: 99%

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Birolli,

Lanças,

dos Santos Neto

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

IntroductionPollution has emerged as a significant threat to humanity, necessitating a thorough evaluation of its impacts. As a result, various methods for human biomonitoring have been proposed as vital tools for assessing, managing, and mitigating exposure risks. Among these methods, urine stands out as the most commonly analyzed biological sample and the primary matrix for biomonitoring studies.ObjectivesThis review concentrates on exploring the literature concerning residual pesticide determination in urine, utilizing liquid and gas chromatography coupled with mass spectrometry, and its practical applications.MethodThe examination focused on methods developed since 2010. Additionally, applications reported between 2015 and 2022 were thoroughly reviewed, utilizing Web of Science as a primary resource.SynthesisRecent advancements in chromatography-mass spectrometry technology have significantly enhanced the development of multi-residue methods. These determinations are now capable of simultaneously detecting numerous pesticide residues from various chemical and use classes. Furthermore, these methods encompass analytes from a variety of environmental contaminants, offering a comprehensive approach to biomonitoring. These methodologies have been employed across diverse perspectives, including toxicological studies, assessing pesticide exposure in the general population, occupational exposure among farmers, pest control workers, horticulturists, and florists, as well as investigating consequences during pregnancy and childhood, neurodevelopmental impacts, and reproductive disorders.Future directionsSuch strategies were essential in examining the health risks associated with exposure to complex mixtures, including pesticides and other relevant compounds, thereby painting a broader and more accurate picture of human exposure. Moreover, the implementation of integrated strategies, involving international research initiatives and biomonitoring programs, is crucial to optimize resource utilization, enhancing efficiency in health risk assessment.

show abstract

Assessing farmer's exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study

Cited by 19 publications

References 51 publications

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA’s ToxCast Database

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA’s ToxCast Database

Impact of Exposure to Pyraclostrobin and to a Pyraclostrobin/Boscalid Mixture on the Mitochondrial Function of Human Hepatocytes

Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications

Contact Info

Product

Resources

About