Forests are widely distributed in terrestrial ecosystems, covering about one-third of the global land area. They play a key role in sequestering carbon, releasing oxygen, mitigating climate change, and maintaining ecosystem balance. The ecology of the Tibetan Plateau is very fragile, but the impact of environmental change on regional forest ecosystems is not yet clear. Located in the Eastern Tibetan Plateau, the Shaluli Mountain has the richest biodiversity and the widest distribution of forests on the Tibetan Plateau. Assessing the dynamics of forest change is the basis for correctly formulating forest management measures, and is important for regional biodiversity conservation. However, traditional field surveys have the shortcomings of high cost, being time-consuming, and having poor regional coverage in forest dynamics monitoring. Remote sensing methods can make up for these shortcomings. Therefore, in this study, satellite remote sensing images were used to extract forest information from 2000 to 2020 in Shaluli Mountain, and the main drivers of forest change were analyzed with full consideration of the Spatially Stratified Heterogeneity (SSH) of environmental factors. The results found that the forest area increased from 23,144.20 km2 in 2000 to 28,429.53 km2 in 2020, and the average Percentage of Forest Cover (PFC) increased from 19.76% to 21.67%, with significant improvement in forest growth. The annual minimum temperature (TMN), altitude, annual maximum temperature (TMX), and annual precipitation (PRE) were the main driving factors of forest change, with an average driving power (q-value) of 0.4877, 0.2706, 0.2342, and 0.2244, and TMN was the primary limiting factor for forest growth. In addition, the driving power of all environmental factors on forest change increased from 2000 to 2020. The results of this study can provide a basis for the development of forest management strategies, and provide reference materials for regional biodiversity conservation.