Assessing Gastrointestinal Tolerance in Healthy Adults: Reliability and Validity of a Weekly Questionnaire

Alvarez, Melissa; Colee, James; Dahl, Wendy J.

doi:10.1016/j.cdnut.2023.101976

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…The survey used to collect GI symptom and severity data was self-reported. This method has been used and reported as an effective measure of gastrointestinal symptoms in various studies [80][81][82]. However, the survey results could be further validated with external observations and ratings by trained medical professionals.…”

Section: Discussionmentioning

confidence: 99%

Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses—A Randomized Clinical Trial

Chamberlin,

Wilson,

Gaston

et al. 2024

Nutrients

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Lentils have potential to improve metabolic health but there are limited randomized clinical trials evaluating their comprehensive impact on metabolism. The aim of this study was to assess the impact of lentil-based vs. meat-based meals on fasting and postprandial measures of glucose and lipid metabolism and inflammation. Thirty-eight adults with an increased waist circumference (male ≥ 40 inches and female ≥ 35 inches) participated in a 12-week dietary intervention that included seven prepared midday meals totaling either 980 g (LEN) or 0 g (CON) of cooked green lentils per week. Linear models were used to assess changes in fasting and postprandial markers from pre- to post-intervention by meal group. Gastrointestinal (GI) symptoms were assessed through a survey randomly delivered once per week during the intervention. We found that regular consumption of lentils lowered fasting LDL (F = 5.53, p = 0.02) and total cholesterol levels (F = 8.64, p < 0.01) as well as postprandial glucose (β = −0.99, p = 0.01), IL-17 (β = −0.68, p = 0.04), and IL-1β (β = −0.70, p = 0.03) responses. GI symptoms were not different by meal group and all symptoms were reported as “none” or “mild” for the duration of the intervention. Our results suggest that daily lentil consumption may be helpful in lowering cholesterol and postprandial glycemic and inflammatory responses without causing GI stress. This information further informs the development of pulse-based dietary strategies to lower disease risk and to slow or reverse metabolic disease progression in at-risk populations.

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Section: Discussionmentioning

confidence: 99%