TanDEM-X digital elevation model (DEM) is a global DEM released by the German Aerospace Center (DLR) at outstanding resolution of 12 m. However, the procedure for its creation involves the combination of several DEMs from acquisitions spread between 2011 and 2014, which casts doubt on its value for precise glaciological change detection studies. In this work we present TanDEM-X DEM as a high-quality product ready for use in glaciological studies. We compare it to Aerial Laser Scanning (ALS)-based dataset from April 2013 (1 m), used as the ground-truth reference, and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) V003 DEM and SRTM v3 DEM (both 30 m), serving as representations of past glacier states. We use a method of sub-pixel coregistration of DEMs by Nuth and Kääb (2011) to determine the geometric accuracy of the products. In addition, we propose a slope-aspect heatmap-based workflow to remove the errors resulting from radar shadowing over steep terrain. Elevation difference maps obtained by subtraction of DEMs are analyzed to obtain accuracy assessments and glacier mass balance reconstructions. The vertical accuracy (± standard deviation) of TanDEM-X DEM over non-glacierized area is very good at 0.02 ± 3.48 m. Nevertheless, steep areas introduce large errors and their filtering is required for reliable results. The 30 m version of TanDEM-X DEM performs worse than the finer product, but its accuracy, −0.08 ± 7.57 m, is better than that of SRTM and ASTER. The ASTER DEM contains errors, possibly resulting from imperfect DEM creation from stereopairs over uniform ice surface. Universidad Glacier has been losing mass at a rate of −0.44 ± 0.08 m of water equivalent per year between 2000 and 2013. This value is in general agreement with previously reported mass balance estimated with the glaciological method for 2012–2014.