2022
DOI: 10.1016/j.puhe.2022.01.011
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Assessing humoral immune response after two doses of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthcare workers

Abstract: Objectives During COVID-19 pandemic, the absence of immunity in the population left them susceptible to infection with SARS-CoV-2; healthcare workers (HCWs) being in the highest risk group. This study intends to assess and follow up the humoral immunity in HCWs vaccinated with an inactive virus vaccine (CoronaVac). Study Design This is a prospective observational study. Methods A total of 1072 HCWs were investigated for the presence of IgG an… Show more

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Cited by 5 publications
(5 citation statements)
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“…In the two‐dose immunization of inactivated vaccines, most of the anti‐S IgG antibodies were detected 14 days after the second dose of vaccination (i.e., 42 days after the first dose) 10 . However, with time and the appearance of new variants, the decreased antibody response of inactivated vaccines has been reported 11,12 . Furthermore, neutralizing antibody titers elicited by an inactivated SARS‐CoV‐2 vaccine were observed to be lower than that of COVID‐19 recovered individuals at 8 months postsymptom onset 13 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In the two‐dose immunization of inactivated vaccines, most of the anti‐S IgG antibodies were detected 14 days after the second dose of vaccination (i.e., 42 days after the first dose) 10 . However, with time and the appearance of new variants, the decreased antibody response of inactivated vaccines has been reported 11,12 . Furthermore, neutralizing antibody titers elicited by an inactivated SARS‐CoV‐2 vaccine were observed to be lower than that of COVID‐19 recovered individuals at 8 months postsymptom onset 13 .…”
Section: Introductionmentioning
confidence: 99%
“…10 However, with time and the appearance of new variants, the decreased antibody response of inactivated vaccines has been reported. 11,12 Furthermore, neutralizing antibody titers elicited by an inactivated SARS-CoV-2 vaccine were observed to be lower than that of COVID-19 recovered individuals at 8 months postsymptom onset. 13 Even though a booster of inactivated vaccine increased antibody levels, the unsatisfactory half-life of neutralizing antibodies was estimated.…”
mentioning
confidence: 97%
“…Our most noticeable result was the regular findings of residual anti-spike antibodies whatever the age or comorbidities of the patients. These findings were surprising as most of the studies on the immunogenicity of SARS-CoV-2 vaccines show a declining humoral immunity with time [14][15][16][17][18]. Although our single time point study does not allow conclusions on the durability of the immune response, it deserves consideration as we have a noticeable longer follow-up than most randomized vaccine trials that are limited to a 6 months follow-up [19].…”
Section: Discussionmentioning
confidence: 83%
“…Demirbakan et al ( 28 ) examined the presence of immunoglobulin G antibodies in the receptor-binding region of the S1 subunit of the SARS-CoV-2 spike protein in 1072 healthcare workers following immunization in a descriptive observational research. 28 days, 21 days, and 3 months following the first, second, and second dosages, respectively, were the times at which blood samples were taken.…”
Section: Resultsmentioning
confidence: 99%