2023
DOI: 10.1042/cs20220146
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Assessing hypothalamic pituitary gonadal function in reproductive disorders

Abstract: Reproductive conditions secondary to disorders of the hypothalamic–pituitary–gonadal (HPG) axis are common and are associated with important health implications and considerable psychosocial impact. Basal and dynamic tests enable interrogation of individual components of the HPG axis, facilitating diagnosis and understanding of the pathophysiology of reproductive disorders. Onset of puberty is controlled by hypothalamic gonadotrophin-releasing hormone (GnRH) neuronal function. To date, a dynamic test of hypoth… Show more

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Cited by 13 publications
(4 citation statements)
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“…27,28 Additionally, the ratio of LH to FSH levels is recognized as an indicator of hypothalamic function, particularly with regard to the frequency of selective gonadotropin secretion pulses. 29 We also reported a sex difference in urinary LH/FSH ratio in our 1995 publication. 30 In this study, we investigated the feasibility of different gonadotropin assays for determining both total and intact LH as well as FSH immunoreactivity in urine (U-LH-ir and U-FSH-ir, respectively), and total U-LH/FSH ratio, in neonates and infants up to 6 months of age.…”
Section: Introductionmentioning
confidence: 63%
“…27,28 Additionally, the ratio of LH to FSH levels is recognized as an indicator of hypothalamic function, particularly with regard to the frequency of selective gonadotropin secretion pulses. 29 We also reported a sex difference in urinary LH/FSH ratio in our 1995 publication. 30 In this study, we investigated the feasibility of different gonadotropin assays for determining both total and intact LH as well as FSH immunoreactivity in urine (U-LH-ir and U-FSH-ir, respectively), and total U-LH/FSH ratio, in neonates and infants up to 6 months of age.…”
Section: Introductionmentioning
confidence: 63%
“…Все больше работ описывают механизмы влияния на репродуктивную ось гипоталамус-гипофиз-яичники через систему кисспептинов, которая включает семейство гипоталамических нейропептидов, кодируемых геном KISS1 у человека [ 29 ]. Инактивация KISS1 и его рецептора, кодируемого KISS1R, приводит к задержке полового созревания и врожденному гипогонадотропному гипогонадизму [ 30 ], и, наоборот, активирующие варианты KISS1R и KISS1 вызывали центральное прежде­временное половое созревание [ 31 ].…”
Section: функциональная гипоталамическая аменореяunclassified
“…As is generally known, EDCs have the capacity to disrupt the normal functioning of the gonads, impacting the regulation of sex hormone biosynthesis controlled by the hypothalamic-pituitary-gonadal (HPG) axis ( 9 , 10 ). The HPG axis serves as a principal modulator of reproductive function, driving processes such as the growth, development, maturation, and ovulation of follicles, as well as spermatogenesis and steroidogenesis ( 11 , 12 ). The regulation of the physiological activities of the human reproductive system involves the hypothalamus, pituitary gland, and gonads, which regulate the secretion of gonadotropin-releasing hormone (GnRH), gonadotropins (Gn), and gonadal hormones (e.g., estrogen, progestogen, and androgen).…”
Section: Introductionmentioning
confidence: 99%