Assessing incidence and economic burden of genital warts with data from a US commercially insured population

Hoy, Tracey; Singhal, Puneet K.; Willey, Vincent J.; Insinga, Ralph P.

doi:10.1185/03007990903136378

Cited by 84 publications

(65 citation statements)

References 36 publications

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“…Our findings are similar to incidence estimates from studies using private health insurance claims that reported GW incidence rates of 1.70 [11], 1.62 [12], and 1.10 [13] cases per 1000 person-years. Those studies also observed the highest GW incidence among younger men.…”

Section: Discussionsupporting

confidence: 88%

“…Misclassification could partially explain why men with genital HPV infections with only oncogenic types had the longest time from infection to lesion development. Because our GW incidence rates are similar to those found in previous studies [11,12,13], it is unlikely that there was extensive misclassification. The generalizability of our findings may also be limited, because men who agree to participate in a 4-year study are likely to not be representative of the underlying population at each study site.…”

Section: Discussionsupporting

confidence: 86%

“…Women tend to have a shorter time from HPV 6/11 infection to GW detection; the placebo arm of a vaccine trial in women reported median times of 5.0 months [19], and the study of female university students reported a median time of 2.9 months [20]. It is not known why GWs develop more slowly in men, but this observation is consistent with findings of peak GW incidence occurring at a slightly older age in men than in women [11,13]. The prevalence of HPV 6/11 in GWs in our study was 54%.…”

Section: Discussionmentioning

confidence: 61%

“…Those studies also observed the highest GW incidence among younger men. Two studies observed peak GW incidence among men aged 25-29 years (5.01 cases per 1000 person-years [13] and 2.7 cases per 1000 person-years [11]), and one study observed the highest incidence among men aged 20-29 years (3.1 cases per 1000 person-years [12] [10]. An enrollment criterion for the clinical trials was having #4 lifetime sexual partners.…”

Section: Discussionmentioning

confidence: 99%

“…Few published studies have reported the HPV type distribution in GWs, the incidence of GWs, and the time from HPV infection to GWs in men. Most published incidence rates of GWs among US men are based on data from private insurance claims [11,12,13]. These data likely underestimate true incidence because they exclude individuals who do not seek treatment or who are not privately insured.…”

Section: Anogenital Human Papillomavirus (Hpv) Is the Most Common Sexmentioning

confidence: 99%

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Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Anic¹,

Lee²,

Stockwell³

et al. 2011

The Journal of Infectious Diseases

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Background. Data on the natural history of human papillomavirus (HPV)-related genital warts (GWs) in men are sparse. We described the distribution of HPV types in incident GWs and estimated GW incidence and time from type-specific incident HPV infections to GW detection in a multinational cohort of men aged 18-70 years.Methods. Participants included 2487 men examined for GWs and tested for HPV every 6 months and followed up for a median of 17.9 months. Samples were taken from 112 men with incident GWs to test for HPV DNA by polymerase chain reaction.Results. Incidence of GWs was 2.35 cases per 1000 person-years, with highest incidence among men aged 18-30 years (3.43 cases per 1000 person-years). HPV 6 (43.8%), HPV 11 (10.7%), and HPV 16 (9.8%) were the genotypes most commonly detected in GWs. The 24-month cumulative incidence of GWs among men with incident HPV 6/11 infections was 14.6% (95% confidence interval [CI], 7.5%-21.1%). Median time to GW detection was 17.1 months (95% CI, 12.4-19.3 months), with shortest time to detection among men with incident infections with HPV 6/11 only (6.2 months; 95% CI, 5.6-24.2 months).Conclusions. HPV 6/11 plays an important role in GW development, with the highest incidence and shortest time to detection among men with incident HPV 6/11 infection.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Anogenital Human Papillomavirus (Hpv) Is the Most Common Sexmentioning

confidence: 99%

See 3 more Smart Citations

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Anic¹,

Lee²,

Stockwell³

et al. 2011

The Journal of Infectious Diseases

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Annual Health Care Utilization and Costs for Treatment of Cutaneous and Anogenital Warts Among a Commercially Insured Population in the US, 2017-2019

2022

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Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males

Truzzi

Silva

Freire

et al. 2020

Diagnostic Cytopathology

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Objectives: To explore male human papillomavirus (HPV) contemporary genotyping epidemiology and correlations to peniscopy, cytology, and histopatology. Methods: Medical records of patients who had been submitted to HPV infection screening with genotyping, peniscopy, cytology, and histopathology in a period of 2 years were reviewed. Frequency analysis and correlations between the diagnostic tools were established. Results: Genotype of 1132 men resulted in 69.2% (784) positivity for HPV DNA, 78% classified as high risk of oncogenesis. Co-infections occurred in 429 (54.7%) and the most frequently identified types were HPV-6, HPV-42, and HPV-16, in 133 (17%), 94 (12%), and 86 (11%) patients, respectively. Positive/negative predictive values of peniscopy, cytology, and histopathology were 83/31%, 92/32%, and 87/33%, respectively. As a result, though significant, the correlations between genotype and non-molecular tests were poor. Conclusions: In the current contemporary representative male cohort, over two thirds are positive for human HPV DNA, 78% of high risk and with over half co-infections. Though significant, its correlation with non-molecular tests is poor and while the positive predictive values of peniscopy, cytology, and histopatology are between 83% and 92%, their negative predictive values are as low as 31% to 33%.

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Assessing incidence and economic burden of genital warts with data from a US commercially insured population

Cited by 84 publications

References 36 publications

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Annual Health Care Utilization and Costs for Treatment of Cutaneous and Anogenital Warts Among a Commercially Insured Population in the US, 2017-2019

Contemporary human papillomavirus genotyping and correlations to peniscopy, cytology, and histopatology on over 1000 males

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