Assessing individual sow risk factors for coliform mastitis: A case–control study

Gerjets, Imke; Traulsen, Imke; Reiners, Kerstin; Kemper, Nicole

doi:10.1016/j.prevetmed.2011.04.012

Cited by 21 publications

(15 citation statements)

References 8 publications

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“…Obstetric aid was more frequently given in sows diagnosed with mastitis, metritis and agalactia [ 57 ], coliform mastitis [ 58 ] and post-farrowing discharge [ 59 ], but the significance of the parturition duration in PDS is obscure [ 4 , 50 , 57 ]. Whether extended parturition and increased obstetric aid cause PDS or vice versa remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Hormonal and metabolic indicators before and after farrowing in sows affected with postpartum dysgalactia syndrome

et al. 2018

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BackgroundPostpartum dysgalactia syndrome (PDS) in sows is difficult to diagnose and the pathogenesis is obscure. Hormonal changes related to the disease are often difficult to distinguish from those found in the normal transition period from gestation to lactation. The study aimed to investigate metabolic and hormonal changes related to PDS with the goal of identifying potential biomarkers in sows suffering from PDS (PDS+). Selected biomarkers were examined by comparing 38 PDS+ sows with 38 PDS negative (PDS-) sows. The sows were sampled every 24 h from 60 h ante partum (a.p.) to 36 h post partum (p.p.).ResultsCompared to the baseline (60 to 36 h a.p.), cortisol in serum and saliva and fasting blood glucose concentrations increased in PDS+ as well as PDS- sows. C-peptide decreased relative to the baseline in PDS+ sows, and prolactin and 8-epi prostaglandin F2 alpha (8-epi-PGF2α) decreased in PDS- sows. Concentrations of cortisol in serum and saliva, salivary chromogranin A (CgA), fasting blood glucose, C-peptide, and 8-epi-PGF2α differed significantly between PDS+ and PDS- sows, with levels of cortisol in serum and saliva, salivary CgA, and 8-epi-PGF2α in serum being different in the two groups already before parturition. Concentrations of salivary CgA were significantly lower in PDS- sows than in PDS+ sows during the entire study period.ConclusionsThe results suggest that salivary CgA, cortisol and serum 8-epi-PGF2α may potentially serve as early diagnostic indicators for PDS. The consistently higher salivary CgA concentration in PDS+ sows compared to PDS- sows may indicate that homeostatic disturbances are present between 36 to 60 h before parturition in sows developing PDS. The higher serum and saliva cortisol concentration in PDS+ sows compared to PDS- sows could reflect an early sign of inflammation or stress. The significantly lower C-peptide in PDS+ sows compared to PDS- sows may reflect a lower food intake. Our results contribute to the understanding of the pathogenesis of PDS, and the homeostatic disturbances detected before parturition warrants further investigation. The diagnostic potential of the markers identified in this study should be investigated further in a larger population of sows.Electronic supplementary materialThe online version of this article (10.1186/s12917-018-1649-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Hormonal and metabolic indicators before and after farrowing in sows affected with postpartum dysgalactia syndrome

et al. 2018

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“…Previous studies demonstrated that prevalence of mastitis in sows was about 13% [2] and it was about 25.5% in lactating heifers in Dutch [3]. For swine, acute clinical mastitis was reported to be associated with reduced piglet growth and survival [4].…”

Section: Introductionmentioning

confidence: 99%

Mammary inflammatory gene expression was associated with reproductive stage and regulated by docosahexenoic acid: in vitro and in vivo studies

et al. 2016

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BackgroundPeriparturient mastitis is the most prevalent disease affecting lactating animals. However, it has long been relied on antibiotics to deal with mastitis, leading to a potential threat to food safety. This study was aimed to investigate the expression of pro-inflammatory cytokines in mammary glands of sows around parturition when mastitis and oxidative stress usually occur, and evaluate the anti-inflammatory effect of docosahexenoic acid (DHA) in porcine mammary epithelial cells (PMEC) challenged by lipopolysaccharide (LPS).MethodsMammary tissues and blood samples were collected from seven pregnant sows at different reproductive stages. Primarily cultured PMEC at passage 4 were assigned to four treatments: basal medium (control), basal medium with LPS (10 μg/mL) (LPS treatment), basal medium with LPS (10 μg/mL) and DHA (100 or 200 μM) (LPS + DHA treatments), and cell samples were harvested after 24 h incubation. The measurements included oxidative stress markers in blood samples and gene expression in mammary tissues and PMEC samples.ResultsSerum α-tocopherol concentration was lower at parturition than at day 90 of gestation and day 28 post parturition, while serum malondialdehyde concentration was higher at day 28 post parturition than at day 90 of gestation. Higher interleukin (IL)-1β mRNA abundance while lower LPS binding protein mRNA abundance in mammary tissues were observed at day 90 of gestation compared with that at parturition and at day 28 and 35 post parturition. Mammary tumor necrosis factor (TNF)-α mRNA abundance were lower at parturition than at day 90 of gestation and day 28 and 35 post parturition, whereas mammary IL-8 mRNA abundance were lower at parturition than at day 35 post parturition. In the PMEC experiment, compared with the control, increased mRNA abundances of Toll-like receptor (TLR)-4 downstream target, myeloid differentiation factor 88 (MyD88), IL-6 and IL-8 were observed in LPS treatment, whereas DHA appeared to decrease mRNA abundances of MyD88, IL-6 and IL-8 induced by LPS.ConclusionsThe down-regulated expression of pro-inflammatory cytokines in mammary tissues and aggravated systemic oxidative stress at parturition suggest that sows are in a vulnerable status during periparturient period. DHA appears to attenuate inflammatory responses in LPS-challenged PMEC through modulation of TLR4 signalling pathway.

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“…Es herrscht Einigkeit darüber, dass MMA eine multifaktorielle Erkrankung ist. Neben der bakteriellen Genese müssen auch andere Faktoren in Betracht gezogen werden, welche mit Ernährung, Unterbringung, Management und Betreuung in Zusammenhang stehen (Martineau et al, 1992;Gerjets et al, 2011 ( Jensen et al, 2004). In der deskriptiven Statistik fielen Variablen auf, die einen signifikanten P-Wert zeigten, bei denen es aber jeweils in Gruppe P oder K keine Nennungen (n= 0) gab.…”

Section: Introductionunclassified

Evaluation of risk factors for Mastitis-Metritis Agalactia in pig farms in Switzerland

Jenny¹,

Vidondo²,

Pendl³

et al. 2015

SAT

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Mastitis-Metritis-Agalactia (MMA), also known as postpartum dysgalactia syndrome (PPDS) is the most important disease complex in sows after birth. The present study compared 30 MMA problem herds (over 12% of farrowing sows affected) with 30 control farms (less than 10% of farrowing sows affected) to identify risk factors and treatment incidence. Important risk factors identified were in gilts the integration into the herd after the first farrowing, in gestating sows firm fecal consistency as well as in lactating sows soiled troughs, a low flow rate (<2 liters per minute) in drinking nipples and a high prevalence of lameness. The treatment incidence was also significantly different between the two groups. The MMA prevalence could be reduced through optimization of husbandry, feeding and management, which could essentially diminish the use of antibiotics.

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Assessing individual sow risk factors for coliform mastitis: A case–control study

Cited by 21 publications

References 8 publications

Hormonal and metabolic indicators before and after farrowing in sows affected with postpartum dysgalactia syndrome

Hormonal and metabolic indicators before and after farrowing in sows affected with postpartum dysgalactia syndrome

Mammary inflammatory gene expression was associated with reproductive stage and regulated by docosahexenoic acid: in vitro and in vivo studies

Evaluation of risk factors for Mastitis-Metritis Agalactia in pig farms in Switzerland

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