Assessing long-term locoregional control of spinal osseous metastases after microwave ablation

Motaghi, Mina; England, Ryan W.; Nejad, N. Hafezi; Sankaran, Nisha; Patel, Ankur R.; Khan, Majid

doi:10.1016/j.jocn.2022.07.025

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…The results of Zhang et al [28] showed that, except for 3 patients who died 12 to 24 weeks after treatment, the postoperative local tumor control rate of was 98%. In a study of 28 patients who underwent MWA combined with vertebral augmentation (57.1% male), the 1-year survival rate of the patients reached 86%, and the 2- and 3-year survival rates were 68% and 56%, respectively [24] (Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…The results showed that the MWA group had a more significant effect on pain relief of spinal metastases in other countries (France, the USA, Egypt, and Turkey) than the RFA group (MWA: mean difference [MD] = 5.27, 95% confidence interval [CI] = 4.85-5.69, P = .590, I 2 = 0%; RFA: MD = 4.83, 95% CI = 4.09-5.56, P = .080, I = 67%), while the study of patients in other countries receiving MWA treatment showed that the heterogeneity also decreased significantly (China: P = .590, I 2 = 0%; others: P = .160, I 2 = 48%). The effect of the mean age [15] 7.0 (±1.8) 2.0 (±1.6) NA 2-4 wk 95% 2.0 (±2.1) NA 20-24 wk Kastler et al [18] 7.2 (±0.97) [24] 7. [25] 6.7 (±1.7) 3.2 (±1.4) P < .001 24 h 100% 1.4 (±1.3) P < .001 4 wk 1.1 (±0.8) P < .001 12 wk 1.0 (±0.7) P < .001 24 wk Chen et al [27] 6 (NA) 5 (NA) P < .05 3 d 86% 3 (NA) P < .05 1 mo 92% 3 (NA) P < .05 3 mo 92% 3 (NA) P < .05 6 mo 89% Zhang et al [28] 6.4 (±2.…”

Section: Subgroup Analysismentioning

confidence: 99%

“…Three of the studies reported that no complications occurred in their cohorts. [24,31,32] Overall, the rest of the studies reported that 27.4% (n = 139) of patients receiving MWA reported complications, while 10.9% (n = 23) of patients receiving RFA had complications. MWA alone or in combination with surgery for spinal metastases has more major complications, including nervous system complications such as nerve injury, nerve function defect, persistent pain, pathological fracture, etc.…”

Section: Postoperative Complicationsmentioning

confidence: 99%

“…Motaghi et al [24] NA One year survival rate was 86%, 68% at 2 yr and 56%at 3 yr NA Wu et al [25] 97.0% NA Ten minor cement leakage (30.3%) Liu et al [26] 83.3% NA One major complications: nerve injury (8.3%) Chen et al [27] 94.8% NA One neural injury (1.1%) and 42 cement leakage (30.0%) Zhang et al [28] 98.0% Three patients died between 12 and 24 wk after the procedure Major complications: 1 pathologic fracture, 1 neurological deficit and 2 mild skin infection (2.0%), 69 cement leakage (34.8%) RFA Zhao et al [29] NA NA One cement leakage (6.3%) Cazzato et al [30] NA One patient died 3 wk later One grade 1 complication (9.1%) and 1 grade 6 complication (9.1%)* Anchala et al [31] NA NA No complication…”

Section: Study Tumor Control Ratementioning

confidence: 99%

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Microwave ablation versus radiofrequency ablation for treating spinal metastases

Yao,

Zhu,

Zhang

et al. 2023

Medicine

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Background: This study aimed to compare the clinical efficacy and safety of microwave ablation (MWA) and radiofrequency ablation (RFA) for the treatment of spinal metastases. Methods: A literature search was performed using the PubMed, Web of Science, and Cochrane Library databases according to the PRISMA statement (as of September 20, 2022). Two independent investigators screened articles based on the inclusion and exclusion criteria and included studies with primary outcomes of pain relief, tumor control, and complications. Article quality was assessed using the Risk Of Bias In Non-randomized Studies of Interventions tool. Results: Sixteen articles were finally included in this study, including 630 patients with spinal metastases, with ages ranging from 51.4 to 71.3 years. Of these, 393 (62.4%) underwent MWA and 237 (37.6%) underwent RFA. After MWA and RFA treatment, visual analog scale scores significantly decreased, and the local tumor control rates were all above 80%. Complications were reported in 27.4% of patients treated with MWA compared with 10.9% of patients treated with RFA. Conclusion: The results of this systematic review suggest that MWA alone or in combination with surgery and RFA in combination with other modalities may improve pain caused by primary tumor metastasis to the spine, and MWA alone or in combination with surgery may have better local tumor control. However, MWA appears to result in more major complications than RFA in combination with other treatment modalities.

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Section: Resultsmentioning

confidence: 99%

Section: Subgroup Analysismentioning

confidence: 99%

Section: Postoperative Complicationsmentioning

confidence: 99%

Section: Study Tumor Control Ratementioning

confidence: 99%

See 2 more Smart Citations

Microwave ablation versus radiofrequency ablation for treating spinal metastases

Yao,

Zhu,

Zhang

et al. 2023

Medicine

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CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report

Guo

et al. 2023

Open Medicine

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Metastatic diseases of the spine are becoming increasingly common with an aging population and improvements in systemic cancer therapies. Microwave and vertebroplasty are the mainstay modalities for treating painful spine metastases. Most early spinal metastases predominantly attack the adnexa, but there are few reports on its treatment. This report presents a case of a 56-year-old female who had experienced severe thoracic back pain for several days and was diagnosed with a metastatic tumor of the right transverse process of T7. Percutaneous microwave ablation in combination with bone cement injection was used to treat the metastatic tumor under CT guidance. The postoperative pain on the Visual Analogue Scale was 1/10, without nerve or vessel damage and bone cement leakage during the operation.

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Exploring the Efficacy of Combining Radiofrequency Thermal Ablation or Microwave Ablation with Vertebroplasty for Pain Control and Disease Management in Metastatic Bone Disease—A Systematic Review

Faiella,

Vaccarino,

Pacella

et al. 2024

Current Oncology

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Background: Interventional radiology techniques have become pivotal in recent years in managing metastatic bone disease, which frequently results in skeletal complications such as fractures and severe pain. Thermoablative methods like radiofrequency ablation (RFA) and microwave ablation (MWA), when combined with vertebroplasty (VP), are proving increasingly beneficial for these patients. Methods: The search was independently conducted by two radiologists on MEDLINE databases, using specified strings up to April 2024. Methodological quality was assessed using PRISMA guidelines. Studies meeting inclusion criteria investigated thermoablation techniques (RFA and/or MWA) combined with VP, focusing on pain management and disease control outcomes in adults. Results: Among 147 results, 42 articles met the criteria, with varied prospective and retrospective designs and sample sizes averaging 49 patients, predominantly involving RFA (30 studies), MWA (11 studies), and one comparative study. Our review highlights significant pain reduction, effective local tumor control, and favorable safety of combined RFA or MWA with VP, supporting its potential in managing vertebral pathologies and warranting further clinical integration. Conclusions: The combined treatment of RFA/MWA with VP demonstrates significant pain reduction and local tumor control, with a rapid onset of analgesic effect. These findings support its crucial role in clinical practice for managing vertebral metastases.

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Assessing long-term locoregional control of spinal osseous metastases after microwave ablation

Cited by 3 publications

References 27 publications

Microwave ablation versus radiofrequency ablation for treating spinal metastases

Microwave ablation versus radiofrequency ablation for treating spinal metastases

CT-guided percutaneous microwave ablation combined with bone cement injection for the treatment of transverse metastases: A case report

Exploring the Efficacy of Combining Radiofrequency Thermal Ablation or Microwave Ablation with Vertebroplasty for Pain Control and Disease Management in Metastatic Bone Disease—A Systematic Review

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