This article examines the idea of disinterestedness using the case of a private MO museum. The philosophical idea of disinterestedness and its reflections in the creative economy are presented. The idea of disinterestedness is explored as a factor of sustainability in economics. The paradoxes as follows related to disinterestedness in general and to the analyzed case in particular are examined. Although disinterestedness covers detachment from any theoretical concepts, it is also an aesthetic concept. Although this is a futile activity from an economic point of view, disinterestedness helps to remain independent from economic fluctuations. Although the founders of the MO Museum do not expect financial benefits, they are characterized by economic thinking in order to balance the museum’s finances. Disinterestedness, although detached from any interests, includes social responsibility for the state of the art, the desire to enrich and educate society, the development of social connections and personal relationships, and the need for interesting activities. Business management requires a broader intention, but art also requires flexible management. This study is important because of the interdisciplinary approach and the aspects of social responsibility and sustainability in business. In addition, this research opens up a new perspective in connecting the idea of disinterestedness not only with the patronage of art but also with the needs of the business itself. The methods used in this article are as follows: analysis of philosophical literature on the topic of disinterestedness and aspects of disinterestedness in the creative economy, a case study that includes interviews with experts (museum founders and director), and their analysis and summarization. The main finding is as follows: disinterestedness in art management and the creative economy is an aspect of economic sustainability that allows both to expand the economic approach and to show its limits.