Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM

Wu, Xu; Li, Yashan; Baohua, Man; Li, Dexuan

doi:10.2147/dmso.s298735

Cited by 17 publications

(7 citation statements)

References 28 publications

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“…Several studies have also linked miR-375 to diabetic retinopathy (47)(48)(49). MiR-375 was also researched as a possible biomarker of T2D development (50)(51). However, the relative quantity of miR-375 was not statistically signifi cantly changed in our study.…”

Section: Discussioncontrasting

confidence: 68%

MiR-126 and miR-146a as markers of type 2 diabetes mellitus: a pilot study

Benko¹,

Šarlinová²,

Mikušová³

et al. 2023

BLL

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INTRODUCTION: Despite known risk factors for developing type 2 diabetes mellitus (T2D), the research community still tries to discover new markers that would widen our diagnostic and therapeutic approach to diabetes. Therefore, research on microRNA (miR) in diabetes thrives. This study aimed to assess the utility of miR-126, miR-146a, and miR-375 as novel diagnostic markers for T2D. METHODS: We examined relative quantities of miR-126, miR-146a, and miR-375 in the serum of patients with established type 2 diabetes mellitus (n = 68) and compared these with a control group (n = 29). We also undertook a ROC analysis of signifi cantly changed miR to examine their use as a diagnostic test. RESULTS: MiR-126 (p < 0.0001) and miR-146a (p = 0.0005) showed a statistically signifi cant reduction in patients with type 2 diabetes mellitus. MiR-126 also proved to be an exceptional diagnostic test in our study cohort, with high sensitivity (91 %) and specifi city (97 %). We did not fi nd any difference in our study groups' relative quantities of miR-375. CONCLUSION: The study proved a statistically signifi cant reduction of miR-126 and miR-146a in patients with T2D (Tab. 4, Fig. 6, Ref. 51).

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Section: Discussioncontrasting

confidence: 68%

MiR-126 and miR-146a as markers of type 2 diabetes mellitus: a pilot study

Benko¹,

Šarlinová²,

Mikušová³

et al. 2023

BLL

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“…Interestingly, another finding has highlighted the pivotal role of miR-375 in predicting T2DM even before onset, thus making it valuable as a prognostic marker [ 27 ]. Consistent with this finding, a recent study to assess miR-375 in diabetes patients and their first-degree relatives by quantitative real-time PCR noted that it may serve as a stable biomarker for an early finding of T2DM among high-risk individuals [ 28 ]. It is already mentioned that miR-375 is predominantly expressed in β cells of the pancreas, overexpression of the aforementioned micro RNA leads to reduced β cell mass via PI3-Akt pathway (phosphatidylinositol 3-kinase, protein kinase B) and subsequently, insulin secretion is curtailed [ 29 ].…”

Section: Introductionmentioning

confidence: 60%

“…In this sense, positioning the correct and on-target miRNA will facilitate the assessment of the progress and intensity of T2DM. individuals [28]. It is already mentioned that miR-375 is predominantly expressed in β cells of the pancreas, overexpression of the aforementioned micro RNA leads to reduced β cell mass via PI3-Akt pathway (phosphatidylinositol 3-kinase, protein kinase B) and subsequently, insulin secretion is curtailed [29].…”

Section: Mirna Signature In Type 2 Diabetes Mellitusmentioning

confidence: 99%

A comprehensive overview on Micro RNA signature in type 2 diabetes Mellitus and its complications

et al. 2022

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MicroRNAs (miRNAs) are small endogenous, non-coding RNA molecules that can modulate the expression of their target genes. Since its discovery, an enormous breakthrough has been established regarding its biogenesis and pathophysiological action, which has revolutionized the field of molecular biology. In addition, recent studies have identified the existence of stable extracellular/circulating miRNAs tissues and in biological fluids like blood where they are safeguarded from endogenous ribonuclease activity. Type 2 diabetes mellitus (T2DM) has emerged as a prime health issue worldwide. Incidence has increased considerably over the past decade. There are various tests that have been employed to diagnose T2DM. But for early detection and development, the establishment of biomarkers are of paramount importance. Contemporary evidence also validates the signature of a set of this epigenetic factor miRNA in the development of various diseases, including T2DM. This article reviews the contemporary corroboration associating miRNAs and T2DM and emphasizes the potential role of miRNA as a circulatory biomarker that could alert the growing prevalence of T2DM. Also, it acknowledges the valuable compendium of information regarding biogenesis and functional role of circulating miRNA in insulin resistance which is intimately linked to T2DM. Supplementary Information The online version contains supplementary material available at 10.1007/s12291-022-01069-1.

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“…In mice, for example, miR-375 is highly expressed in healthy β-cells regulating the expression of several genes that are implicated in normal insulin secretion, such as Glut2, which is involved in glucose uptake, and Pdx-1, which plays a key role in β-cell function [271]. At the same time though, miR-375 has been found to be dysregulated both in experimental [273,274] and real-life conditions related to T2D [275]. In addition, other malfunctioning miRNAs have been found to play a role in β-cell failure and T2D pathogenesis, such as miR-7, miR-9, miR-29, and miR-30d, among several others [272,276].…”

Section: Role Of Mirnas Dysfunctionmentioning

confidence: 99%

Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients

et al. 2023

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Traditionally a disease of adults, type 2 diabetes (T2D) has been increasingly diagnosed in youth, particularly among adolescents and young adults of minority ethnic groups. Especially, during the recent COVID-19 pandemic, obesity and prediabetes have surged not only in minority ethnic groups but also in the general population, further raising T2D risk. Regarding its pathogenesis, a gradually increasing insulin resistance due to central adiposity combined with a progressively defective β-cell function are the main culprits. Especially in youth-onset T2D, a rapid β-cell activity decline has been observed, leading to higher treatment failure rates, and early complications. In addition, it is well established that both the quantity and quality of food ingested by individuals play a key role in T2D pathogenesis. A chronic imbalance between caloric intake and expenditure together with impaired micronutrient intake can lead to obesity and insulin resistance on one hand, and β-cell failure and defective insulin production on the other. This review summarizes our evolving understanding of the pathophysiological mechanisms involved in defective insulin secretion by the pancreatic islets in youth- and adult-onset T2D and, further, of the role various micronutrients play in these pathomechanisms. This knowledge is essential if we are to curtail the serious long-term complications of T2D both in pediatric and adult populations.

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Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM

Cited by 17 publications

References 28 publications

MiR-126 and miR-146a as markers of type 2 diabetes mellitus: a pilot study

MiR-126 and miR-146a as markers of type 2 diabetes mellitus: a pilot study

A comprehensive overview on Micro RNA signature in type 2 diabetes Mellitus and its complications

Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients

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