Assessing mindfulness-based cognitive therapy intervention for tinnitus using behavioural measures and structural MRI: a pilot study

Husain, Fatima T.; Zimmerman, Benjamin; Tai, Yihsin; Finnegan, Megan; Kay, Emily; Khan, Faaiza; Menard, Christopher; Gobin, Robyn L.

doi:10.1080/14992027.2019.1629655

Cited by 18 publications

(13 citation statements)

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“…VBM analysis revealed clusters in bilateral SFG that exhibited significant increases in gray matter volume over the period of intervention and follow-up. Furthermore, gray matter changes in occipital and cingulate regions correlated with declines in tinnitus handicap (Husain et al, 2019). The analysis in our study was performed after 3 months of treatment with narrow band sound therapy, with a longer treatment time and a relatively better treatment effect.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Xuan

Wang

et al. 2020

Front. Neurosci.

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According to previous studies, many neuroanatomical alterations have been detected in patients with tinnitus. However, few studies have reported on the morphological changes observed following sound therapy. To explore the brain anatomical alterations in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis before and after effective 12 weeks sound therapy. The protocol was registered on ClinicalTrials.gov, ID: NCT02774122. In this study, we collected data from 27 matched healthy control (HC) individuals and 27 idiopathic tinnitus patients before and after 12 weeks of sound therapy by using adjusted narrow band sound. 3.0T MRI system and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Mann-Whitney U Test, Wilcoxon Signed-Ranks test, and Pearson's correlation analysis were used in the statistical analysis. We found significantly decreased gray matter (GM) volume in the left thalami, right thalami, and cochlear nucleus among the tinnitus patients before sound therapy (baseline) compared to the HC group. However, we did not find significant differences in brain regions between the 12-week treatment and HC groups. According to the results of Wilcoxon Signed-Ranks test, the 12-week sound therapy group demonstrated significant greater brain volume compared with the baseline group among these brain regions. Decreased THI score and changed GM volume were not correlated. This is a useful study for observing the characteristics of neuroanatomical changes in patients with idiopathic tinnitus before and after sound treatment. The study characterized the effect of sound therapy on brain volume. It found that sound therapy had a normalizing effect on the bilateral thalami and cochlear nucleus.

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Section: Discussionmentioning

confidence: 99%

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Xuan

Wang

et al. 2020

Front. Neurosci.

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“…TFI, BDI, and BAI were given at each of three MRI sessions. The behavioral data for this study was previously analyzed and reported in Husain et al (2019) and provided evidence for significant improvement in self-reported tinnitus severity. The focus of this study was to examine the change in functional MRI measures across the MBCT intervention and to analyze the relationship between brain function and tinnitus severity as the variables change over the course of the study.…”

Section: Methodsmentioning

confidence: 94%

“…Participants received a complete audiological evaluation during an initial screening phase, as well as pre-intervention (week 0), post-intervention (week 8) and at an 8-week follow-up session. The full audiological screening and follow-up audiology assessments were reported in Husain et al (2019).…”

Section: Methodsmentioning

confidence: 99%

“…In the current pilot study, we build upon results presented in Husain et al (2019) showing a reduction in tinnitus severity after a mindfulness-based cognitive therapy (MBCT) intervention by analyzing the functional MRI (fMRI) data in the same subjects. We analyzed changes in brain activity during an auditory emotion task and during resting state across three sessions before, immediately after treatment, and 8 weeks after the treatment ended.…”

Section: Introductionmentioning

confidence: 99%

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Functional Brain Changes During Mindfulness-Based Cognitive Therapy Associated With Tinnitus Severity

et al. 2019

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Mindfulness-based therapies have been introduced as a treatment option to reduce the psychological severity of tinnitus, a currently incurable chronic condition. This pilot study of twelve subjects with chronic tinnitus investigates the relationship between measures of both task-based and resting state functional magnetic resonance imaging (fMRI) and measures of tinnitus severity, assessed with the Tinnitus Functional Index (TFI). MRI was measured at three time points: before, after, and at follow-up of an 8-week long mindfulness-based cognitive therapy intervention. During the task-based fMRI with affective sounds, no significant changes were observed between sessions, nor was the activation to emotionally salient compared to neutral stimuli significantly predictive of TFI. Significant results were found using resting state fMRI. There were significant decreases in functional connectivity among the default mode network, cingulo-opercular network, and amygdala across the intervention, but no differences were seen in connectivity with seeds in the dorsal attention network (DAN) or fronto-parietal network and the rest of the brain. Further, only resting state connectivity between the brain and the amygdala, DAN, and fronto-parietal network significantly predicted TFI. These results point to a mostly differentiated landscape of functional brain measures related to tinnitus severity on one hand and mindfulness-based therapy on the other. However, overlapping results of decreased amygdala connectivity with parietal areas and the negative correlation between amygdala-parietal connectivity and TFI is suggestive of a brain imaging marker of successful treatment.

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“…Our literature search did not yield any specific clinical validation studies of CBT apps directly applied to tinnitus. However, in one study given in [72], the effectiveness of CBT in tinnitus has been discussed and has shown positive results. The participants of the study reported reduced TFI scores after receiving mindfulness-based CBT therapy.…”

Section: Smartphone-based Cbtmentioning

confidence: 99%

Smartphone Apps in the Context of Tinnitus: Systematic Review

Mehdi

Riha

Neff

et al. 2020

Sensors

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Smartphones containing sophisticated high-end hardware and offering high computational capabilities at extremely manageable costs have become mainstream and an integral part of users’ lives. Widespread adoption of smartphone devices has encouraged the development of many smartphone applications, resulting in a well-established ecosystem, which is easily discoverable and accessible via respective marketplaces of differing mobile platforms. These smartphone applications are no longer exclusively limited to entertainment purposes but are increasingly established in the scientific and medical field. In the context of tinnitus, the ringing in the ear, these smartphone apps range from relief, management, self-help, all the way to interfacing external sensors to better understand the phenomenon. In this paper, we aim to bring forth the smartphone applications in and around tinnitus. Based on the PRISMA guidelines, we systematically analyze and investigate the current state of smartphone apps, that are directly applied in the context of tinnitus. In particular, we explore Google Scholar, CiteSeerX, Microsoft Academics, Semantic Scholar for the identification of scientific contributions. Additionally, we search and explore Google’s Play and Apple’s App Stores to identify relevant smartphone apps and their respective properties. This review work gives (1) an up-to-date overview of existing apps, and (2) lists and discusses scientific literature pertaining to the smartphone apps used within the context of tinnitus.

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Assessing mindfulness-based cognitive therapy intervention for tinnitus using behavioural measures and structural MRI: a pilot study

Cited by 18 publications

References 50 publications

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Voxel-Based Morphometry Study

Functional Brain Changes During Mindfulness-Based Cognitive Therapy Associated With Tinnitus Severity

Smartphone Apps in the Context of Tinnitus: Systematic Review

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