Assessing PD-L1 Expression in Head and Neck Squamous Cell Carcinoma: Trials and Tribulations

Bill, Ruben; Faquin, William C.; Pai, Sara I.

doi:10.1007/s12105-023-01590-6

Head and Neck Pathol

2023

DOI: 10.1007/s12105-023-01590-6

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Assessing PD-L1 Expression in Head and Neck Squamous Cell Carcinoma: Trials and Tribulations

Ruben Bill,

William C. Faquin,

Sara I. Pai

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2024

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Cited by 3 publications

References 36 publications

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Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma

Santana,

Krüger,

Abrahão

et al. 2024

Head and Neck Pathol

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Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma

Santana,

Krüger,

Abrahão

et al. 2024

Head and Neck Pathol

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CMTM6 status predicts survival in head and neck squamous cell carcinoma and correlates with PD-L1 expression

Becker,

Wieder,

Zonnur

et al. 2024

Discov Onc

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We retrospectively analyzed 129 treatment-naïve head and neck squamous cell carcinomas (HNSCCs) for the expression of programmed death ligand 1 (PD-L1), CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6), tumor-infiltrating leukocytes (TILs), and tumor-associated macrophages (TAMs). We evaluated the relationships among these markers, human papilloma virus (HPV) status, and overall survival (OS). PD-L1 and CMTM6 (combined positive score (CPS) ≥ 1 and ≥ 5) were detected in ~ 70% of HNSCCs. HPV status had insignificant effects on marker expression. Most PD-L1-positive cases showed concomitant CMTM6 expression with comparable staining patterns. While PD-L1 and CMTM6 mRNA expression levels correlated with PD-L1 and CMTM6 protein status, no significant correlation was observed for PD-L1 and CMTM6 mRNA expression. Tumors expressing PD-L1 (p < 0.0001) and/or CMTM6 (p < 0.05) were associated with the best OS. A high density of TILs (p < 0.01), CD8+ T cells (p < 0.001), and CD68/CD163 ratio > 1 were prognostically relevant. In addition to HPV status, PD-L1 and CD8+ T cells, CMTM6 was identified as an independent prognostic factor using a multivariate Cox regression analysis. PD-L1 and CMTM6 correlated with TILs and CD8+ cells but not with HPV. Our results identified CMTM6 as an important interaction partner in the crosstalk between TILs, CD8+ T cells, and PD-L1, which mediates anticancer efficacy. Assessments of CMTM6 may be helpful for prognostic prediction, and it may serve as a reliable biomarker for immunotherapy selection.

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Comment on betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study

Sekar

2024

Oral Oncology

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Assessing PD-L1 Expression in Head and Neck Squamous Cell Carcinoma: Trials and Tribulations

Cited by 3 publications

References 36 publications

Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma

Chronic Lymphocytic Thyroiditis with Oncocytic Metaplasia Influences PD-L1 Expression in Papillary Thyroid Carcinoma

CMTM6 status predicts survival in head and neck squamous cell carcinoma and correlates with PD-L1 expression

Comment on betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study

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