Assessing prevention measures and sin nombre hantavirus seroprevalence among workers at Yosemite National Park

Wilken, Jason A.; Jackson, Rebecca; Materna, Barbara L.; Windham, Gayle C.; Enge, Barryett; Messenger, Sharon; Xia, Dongxiang; Knust, Barbara; Buttke, Danielle; Roisman, Rachel

doi:10.1002/ajim.22445

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…During the last decades, hantaviruses have emerged as endemic and often ignored pathogens in most of Western Europe [50,[62][63][64][65][66], but also in North and South America [51,52,[67][68][69][70][71][72][73]. Our meta-analysis on hantavirus in agricultural and forestry workers estimated a pooled seroprevalence of 3.7% and 3.8%, respectively, with substantial heterogeneity across the assessed areas, but highly consistent across the assessed timeframe (i.e., 1972-2020).…”

Section: Discussionmentioning

confidence: 70%

Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis

Riccò

Peruzzi

Ranzieri

et al. 2021

Viruses

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Hantaviruses are zoonotic pathogens that can cause serious human disorders, including hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. As the main risk factor for human infections is the interaction with rodents, occupational groups such as farmers and forestry workers are reportedly at high risk, but no summary evidence has been collected to date. Therefore, we searched two different databases (PubMed and EMBASE), focusing on studies reporting the prevalence of hantaviruses in farmers and forestry workers. Data were extracted using a standardized assessment form, and results of such analyses were systematically reported, summarized and compared. We identified a total of 42 articles, including a total of 28 estimates on farmers, and 22 on forestry workers, with a total workforce of 15,043 cases (821 positive cases, 5.5%). A pooled seroprevalence of 3.7% (95% confidence interval [95% CI] 2.2–6.2) was identified in farmers, compared to 3.8% (95% CI 2.6–5.7) in forestry workers. Compared to the reference population, an increased occurrence was reported for both occupational groups (odds ratio [OR] 1.875, 95% CI 1.438–2.445 and OR 2.892, 95% CI 2.079–4.023 for farmers and forestry workers, respectively). In summary, our analyses stress the actual occurrence of hantaviruses in selected occupational groups. Improved understanding of appropriate preventive measures, as well as further studies on hantavirus infection rates in reservoir host species (rodents, shrews, and bats) and virus transmission to humans, is needed to prevent future outbreaks.

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Section: Discussionmentioning

confidence: 70%

Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis

Riccò

Peruzzi

Ranzieri

et al. 2021

Viruses

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“…musculus tends to transmit pathogens due to high coexistence with humans (e.g., inside a house by contaminating food with urine and feces) [ 15 , 24 ], while pathogens transmitted by P . maniculatus are often transmitted to people with outdoor-related activities, such as working in fields or forested areas, or recreational activities in natural areas [ 83 , 84 ].…”

Section: Discussionmentioning

confidence: 99%

Association between anthropization and rodent reservoirs of zoonotic pathogens in Northwestern Mexico

Mendoza,

López-Pérez,

Rubio

et al. 2024

PLoS ONE

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The world is facing a major pulse of ecological and social changes that may favor the risk of zoonotic outbreaks. Such risk facilitation may occur through the modification of the host’s community diversity and structure, leading to an increase in pathogen reservoirs and the contact rate between these reservoirs and humans. Here, we examined whether anthropization alters the relative abundance and richness of zoonotic reservoir and non-reservoir rodents in three Socio-Ecological Systems. We hypothesized that anthropization increases the relative abundance and richness of rodent reservoirs while decreasing non-reservoir species. We first developed an Anthropization index based on 15 quantitative socio-ecological variables classified into five groups: 1) Vegetation type, 2) Urbanization degree, 3) Water quality, 4) Potential contaminant sources, and 5) Others. We then monitored rodent communities in three regions of Northwestern Mexico (Baja California, Chihuahua, and Sonora). A total of 683 rodents of 14 genera and 27 species were captured, nine of which have been identified as reservoirs of zoonotic pathogens (359 individuals, 53%). In all regions, we found that as anthropization increased, the relative abundance of reservoir rodents increased; in contrast, the relative abundance of non-reservoir rodents decreased. In Sonora, reservoir richness increased with increasing anthropization, while in Baja California and Chihuahua non-reservoir richness decreased as anthropization increased. We also found a significant positive relationship between the anthropization degree and the abundance of house mice (Mus musculus) and deer mice (Peromyscus maniculatus), the most abundant reservoir species in the study. These findings support the hypothesis that reservoir species of zoonotic pathogens increase their abundance in disturbed environments, which may increase the risk of pathogen exposure to humans, while anthropization creates an environmental filtering that promotes the local extinction of non-reservoir species.

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“…The mechanisms and reasons for this are poorly understood. Even in high-risk groups in Nebraska, California, Texas, and New Mexico, such as field workers and forest workers, the exposure to SNV is limited with seroprevalences of <1% [22][23][24]. Understanding the hantavirus dynamics in the reservoir host population and comparisons between areas with high and low transmission risk might help elucidate answers to these questions regarding SNV and other hantaviruses.…”

Section: Discussionmentioning

confidence: 99%

Continuing Orthohantavirus Circulation in Deer Mice in Western Montana

Williamson

Meade-White

Boardman

et al. 2021

Viruses

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Hantavirus pulmonary syndrome (HPS) is an often-fatal disease caused by New World hantaviruses, such as Sin Nombre orthohantavirus (SNV). In the US, >800 cases of HPS have been confirmed since it was first discovered in 1993, of which 43 were reported from the state of Montana. The primary cause of HPS in the US is SNV, which is primarily found in the reservoir host Peromyscus maniculatus (deer mouse). The reservoir host covers most of the US, including Montana, where multiple studies found SNV in local deer mouse populations. This study aimed to check the prevalence of SNV in the deer mice at popular recreation sites throughout the Bitterroot Valley in Western Montana as compared to previous studies in western Montana. We found high prevalence (up to 20%) of deer mice positive for SNV RNA in the lungs. We were unable to obtain a SNV tissue culture isolate from the lungs but could passage SNV from lung tissue into naïve deer mice. Our findings demonstrate continuing circulation of SNV in western Montana.

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Assessing prevention measures and sin nombre hantavirus seroprevalence among workers at Yosemite National Park

Cited by 9 publications

References 21 publications

Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis

Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis

Association between anthropization and rodent reservoirs of zoonotic pathogens in Northwestern Mexico

Continuing Orthohantavirus Circulation in Deer Mice in Western Montana

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