2023
DOI: 10.1021/jacs.3c00829
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Assessing Readability of an 8-Letter Expanded Deoxyribonucleic Acid Alphabet with Nanopores

Abstract: Chemists have now synthesized new kinds of DNA that add nucleotides to the four standard nucleotides (guanine, adenine, cytosine, and thymine) found in standard Terran DNA. Such "artificially expanded genetic information systems" are today used in molecular diagnostics; to support directed evolution to create medically useful receptors, ligands, and catalysts; and to explore issues related to the early evolution of life. Further applications are limited by the inability to directly sequence DNA containing nons… Show more

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Cited by 8 publications
(1 citation statement)
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“…The ratio in this mixture is very sensitive to condition, makes the bioinformatic analysis challenging, and preventing the analysis of very complex mixtures. In collaboration with Andrew Laszlo teams, we have recently published preliminary data suggesting the possibility of using nanopores to sequence expanded genetic alphabets 18 . Similar approaches have been studied for hydrophobic unnatural nucleotides 19 .…”
Section: Introductionmentioning
confidence: 99%
“…The ratio in this mixture is very sensitive to condition, makes the bioinformatic analysis challenging, and preventing the analysis of very complex mixtures. In collaboration with Andrew Laszlo teams, we have recently published preliminary data suggesting the possibility of using nanopores to sequence expanded genetic alphabets 18 . Similar approaches have been studied for hydrophobic unnatural nucleotides 19 .…”
Section: Introductionmentioning
confidence: 99%